Health Outcomes and Biomarkers
Duchenne and Becker muscular dystrophies are X-linked, genetic disorders caused due to defects in the DMD gene, leading to abnormal dystrophin (missing in Duchenne muscular dystrophy [DMD] or partially functional in Becker muscular dystrophy [BMD]). Among other things, our research aims to understand
We use clinical outcome (from clinical trials and natural history studies) and biomarkers data, both molecular (proteins, microRNAs, mRNAs, genetic modifiers) and digital (accelerometer-based) for understanding these rare diseases better.
Cluster and classification analysis (Statistical Learning)
We develop new mixture models (and software) for cluster and classification analysis. Among other things, these can help with
We develop new phylogenetic models that allow us to test evolutionary hypotheses given a phylogenetic tree. Among other things, these have involved