Referred Articles (Published and Accepted)
Subedi, S, and Dang, UJ (2025). Multivariate Poisson lognormal distribution for modeling counts from modern biological data: An overview. Computational and Structural Biotechnology Journal. Accepted.
Tomoko McGaughey, George Kephart, Utkarsh J. Dang, Paul A. Peters. Creating an Inclusive Definition for High System Inpatient Hospital Users Between and Within Rurality. International Journal of Environmental Research and Public Health. 22 (3), 381. https://doi.org/10.3390/ijerph22030381
Fang, Y, Dang, UJ, Illei, KI, Clemens, PR, and Hoffman, EP on behalf of CINRG, VISION DMD Investigators. (2025) Association of DMD gene variant classes with motor outcomes in a drug registration clinical trial setting. Neurology: Genetics. 11(2). https://doi.org/10.1212/NXG.0000000000200251
Ahmet, A, Tobin, R, Dang, UJ, Rooman, R, Guglieri M, Clemens PR, Hoffman, EP, Ward, LM. (2024) Adrenal suppression from vamorolone and prednisone in Duchenne muscular dystrophy: results from the phase 2b clinical trial. The Journal of Clinical Endocrinology & Metabolism. 110(2), 334-344. https://doi.org/10.1210/clinem/dgae521
Tu, W, Dang, U.J., Subedi, S. (2024), Change point detection via Gaussian Mixture Models. Journal of Statistical Research. 58(1), 197–219. Paper.
Li, X., Sabbatini, D., Pegoraro, E., Bello, L., Clemens, P., Guglieri, M., van den Anker, J., Damsker, J., McCall, J., Dang, U.J., Hoffman, E.P. and Jusko, W.J. (2024), Assessing Pharmacogenomic loci Associated with the Pharmacokinetics of Vamorolone in Boys with Duchenne Muscular Dystrophy. J Clin Pharm. 64: 1130-1140. https://doi.org/10.1002/jcph.2446
Hoffman E, Gaglianone S, Ketema R, Tu W, Peay H, Clemens P, Dang U, Conklin L (2024), Return of participant-level clinical trial results to participants: pilot of a simplified centralised approach BMJ Open;14:e080097. https://doi.org/10.1136/bmjopen-2023-080097
Dang, UJ, Damsker, JM, Guglieri, M, Clemens, PR, Perlman, SJ, Smith, EC, Horrocks, I, Finkel, RS, Mah, JK, Deconinck, N, Goemans, N, Haberlova, J, Straub, V, Mengle-Gaw LJ, Schwartz, BD, Harper, AD, Shieh, PB, De Waele, L, Castro, D, Yang, ML, Ryan, MM, McDonald, CM, Tulinius, M, Webster, R, McMillan, HJ, Kuntz, NL, Rao, VK, Baranello, G, Spinty, S, Childs, AM, Sbrocchi, AM, Selby, K, Monduy, M, Nevo, Y, Vilchez-Padilla, J, Nascimento-Osorio, A, Niks, EH, de Groot, IJM, Katsalouli, M, van den Anker, J, Ward, LM, Leinonen, M, D’Alessandro, A, Hoffman, EP. (2024) Efficacy and safety of vamorolone over 48 weeks in a randomized, double-blind trial in Duchenne muscular dystrophy. Neurology. 102(5). https://doi.org/10.1212/WNL.0000000000208112
Clemens PR, Gordish-Dressman H, Niizawa GA, Gorni K, Guglieri M, Connolly A, Wicklund M, Bertorini T, Mah JK, Thangarajh M, Smith E, Kuntz N, McDonald CM, Henricson EK, Upadhyayula S, Byrne B, Manousakis G, Harper A, Iannaccone S, Dang, U.J. (2024) Findings from the longitudinal CINRG Becker Natural History Study dataset. Journal of Neuromuscular Diseases. 11 (1) 201-212. https://doi.org/10.3233/JND-230178
Roy, R, Dang, U.J., Huffman, K M, Alayi, T, Hathout, Y, Nagaraju, K, Visich, P S, Hoffman, E P. (2024). A population-based study of children suggests blunted morning cortisol rhythms are associated with alterations of the systemic inflammatory state. Psychoneuroendocrinology. 159, 106411. https://doi.org/10.1016/j.psyneuen.2023.106411
Fang, Y., McDonald, C.M., Clemens, P.R., Gordish-Dressman, H., Illei, K., Hoffman, E.P., CINRG DNHS and Vamorolone 002/003/LTE Investigators, and Dang, U.J. (2023). Modeling early heterogeneous rates of progression in boys with Duchenne muscular dystrophy. Journal of Neuromuscular Diseases. 10(3):349–364. https://doi.org/10.3233/JND-221527
Dang, U.J., Gallaugher, M. P. B., Browne, R. P., & McNicholas, P. D. (2023). Model-Based Clustering and Classification Using Mixtures of Multivariate Skewed Power Exponential Distributions. Journal of Classification, 40(1), 145–167. https://doi.org/10.1007/s00357-022-09427-7
Phung, K, McAdam, L, Ma, J, McMillan, H.J., Jackowski, S.A., Scharke, M., Matzinger, M, Shenouda, Koujok, K, Jaremko, J.L., Smit, K., Walker, S., Hartigan, C., Khan, N, Konji, V.N., MacLeay, L., Page, M., Sykes, E., Robinson, M., Alos, N, Cummings, E.A., Ho, J., Sbrocchi, A.M., Stein, R., Saleh, D., Craven, B.C., Dang, U.J., Siminoski, K., Rauch, F., Ward, L.M. (2023) Risk Factors Associated with Prevalent Vertebral Fractures in Duchenne Muscular Dystrophy. Osteoporosis International. 34, pages 147–160. https://doi.org/10.1007/s00198-022-06578-6
Guglieri, M, Clemens, PR, Perlman, SJ, Smith, EC, Horrocks, I, Finkel, RS, Mah, JK, Deconinck, N, Goemans, N, Haberlova, J, Straub, V, Mengle-Gaw LJ, Schwartz, BD, Harper, AD, Shieh, PB, De Waele, L, Castro, D, Yang, ML, Ryan, MM, McDonald, CM, Tulinius, M, Webster, R, McMillan, HJ, Kuntz, NL, Rao, VK, Baranello, G, Spinty, S, Childs, AM, Sbrocchi, AM, Selby, K, Monduy, M, Nevo, Y, Vilchez-Padilla, J, Nascimento-Osorio, A, Niks, EH, de Groot, IJM, Katsalouli, M, James, MK, van den Anker, J, Damsker, JM, Ahmet, A, Ward, LM, Jaros, M, Shale, P, Dang, UJ, Hoffman, EP (2022) Vamorolone versus placebo and prednisone in Duchenne muscular dystrophy. A randomized clinical trial. JAMA Neurology. 79(10):1005–1014. https://doi.org/10.1001/jamaneurol.2022.2480
Sun, M., Dang, U.J., Yuan, Y., Psaras, A.M., Osipitan, O., Brooks, T.A., Lu, F., Di Pasqua, A.J. (2022). Optimization of DOTAP/chol cationic liposomes for mRNA, pDNA and oligonucleotide delivery. AAPS PharmSciTech 23, no. 5 (2022): 1-10. https://doi.org/10.1208/s12249-022-02294-w
Mah, J. K., Clemens, P. R., Guglieri, M., Smith, E. C., Finkel, R. S., Tulinius, M., Nevo, Y., Ryan, M. M., Webster, R., Castro, D., Kuntz, N. L., McDonald, C. M., Damsker, J. M., Schwartz, B. D., Mengle-Gaw, L. J., Jackowski, S., Stimpson, G., Ridout, D. A., Ayyar-Gupta, V. Baranello, G., Manzur, A Y Muntoni, F, Gordish-Dressman, H, Leinonen, M, Ward, L M, Hoffman, E P, Dang, U.J., NorthStar UK Network and CINRG DNHS Investigators (2022). Efficacy and safety of vamorolone in Duchenne muscular dystrophy: A 30-month non-randomized open-label extension study. JAMA Network Open. 5(1):e2144178. https://doi.org/10.1001/jamanetworkopen.2021.44178
Roy, R., Soldin, S. J., Stolze, B., Barbieri, M., Tawalbeh, S. M., Rouhana, N., Fronczek, A. E., Nagaraju, K., van den Anker, J., Dang, U. J., & Hoffman, E. P. (2022). Acute serum protein and cytokine response of single dose of prednisone in adult volunteers. Steroids, 108953. https://doi.org/10.1016/j.steroids.2021.108953
Novak, J. S., Spathis, R., Dang, U. J., Fiorillo, A. A., Hindupur, R., Tully, C. B., Mázala, D. A. G., Canessa, E., Brown, K. J., Partridge, T. A., Hathout, Y., & Nagaraju, K. (2021). Interrogation of Dystrophin and Dystroglycan Complex Protein Turnover After Exon Skipping Therapy. Journal of Neuromuscular Diseases, 8, S383–S402. https://doi.org/10.3233/JND-210696
Ogundele M, Zhang JS, Goswami MV, Barbieri ML, Dang U.J., Novak JS, Hoffman EP, Nagaraju K, CINRG-DNHS Investigators, Hathout Y. Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy. Life. 2021; 11(8):827. https://doi.org/10.3390/life11080827
Ziemba, M., Barkhouse, M., Uaesoontrachoon, K., Giri, M., Hathout, Y., Dang, U.J., Gordish-Dressman, H., Nagaraju, K., and Hoffman, E.P., 2021. Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice. PLoS ONE, 16(2), p.e0246507. https://doi.org/10.1371/journal.pone.0246507
Tawalbeh, S., Samsel, A., Gordish-Dressman, H., Hathout, Y., Investigators, C.-D., and Dang, U.J. (2020) Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys. Journal of Personalized Medicine 10, 164. https://doi.org/10.3390/jpm10040164
Smith, E.C., Conklin, L.S., Hoffman, E.P., Clemens, P.R., Mah, J.K., Finkel, R.S., Guglieri, M, Tulinius, M., Nevo, Y., Ryan, M.M., Richard Webster MD, Diana Castro MD, Kuntz, N.L., Kerschner, L., Morgenroth, L.P., Arrieta, A., Shimony, M., Jaros, M., Phil Shale PhD, Gordish-Dressman, H., Hagerty, L., Dang, U.J., Damsker, J. M., Schwartz, B.D., Mengle-Gaw, L.J., McDonald, C.M. and the CINRG VBP15 and DNHS Investigators (2020). Efficacy and safety of vamorolone in Duchenne muscular dystrophy. An 18-month non-randomized open-label extension study. PLOS Medicine 17(9): e1003222. https://doi.org/10.1371/journal.pmed.1003222
Tawalbeh, S. M., Marin, W., Morgan, G. A., Dang, U. J., Hathout, Y., & Pachman, L. M. (2020). Serum protein biomarkers for juvenile dermatomyositis: a pilot study. BMC Rheumatology, 4(1), 52. https://doi.org/10.1186/s41927-020-00150-7
Dang, U. J., Ziemba, M., Clemens, P. R., Hathout, Y., Conklin, L. S., Investigators, C. V. 002/003, & Hoffman, E. P. (2020). Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys. Human Molecular Genetics, 29(15), 2481–2495. https://doi.org/10.1093/hmg/ddaa132
Hathout, Y., Liang, C., Ogundele, M., Xu, G., Tawalbeh, S. M., Dang, U. J., Hoffman, E. P., Gordish-Dressman, H., Conklin, L. S., van den Anker, J. N., Clemens, P. R., Mah, J. K., Henricson, E., & McDonald, C. (2019). Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy. Scientific Reports, 9(1), 12167. https://doi.org/10.1038/s41598-019-48548-9
Sun, M., Shi, Y., Dang, U. J., & di Pasqua, A. J. (2019). Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer. Molecules, 24(4). https://doi.org/10.3390/molecules24040801
Furman, B. L. S., Dang, U. J., Evans, B. J., & Golding, G. B. (2018). Divergent subgenome evolution after allopolyploidization in African clawed frogs (Xenopus). Journal of Evolutionary Biology, 31(12), 1945–1958. https://doi.org/https://doi.org/10.1111/jeb.13391
Mogle, B. T., Steele, J. M., Seabury, R. W., Dang, U. J., & Kufel, W. D. (2018). Implementation of a two-point pharmacokinetic AUC-based vancomycin therapeutic drug monitoring approach in patients with methicillin-resistant Staphylococcus aureus bacteraemia. International Journal of Antimicrobial Agents, 52(6), 805–810. https://doi.org/https://doi.org/10.1016/j.ijantimicag.2018.08.024
Dang, U. J., Punzo, A., McNicholas, P. D., Ingrassia, S., & Browne, R. P. (2017). Multivariate Response and Parsimony for Gaussian Cluster-Weighted Models. Journal of Classification, 34(1), 4–34. https://doi.org/10.1007/s00357-017-9221-2
Dang, UJ, Devault, A. M., Mortimer, T. D., Pepperell, C. S., Poinar, H. N., & Golding, G. B. (2016). Estimation of Gene Insertion/Deletion Rates with Missing Data. Genetics, 204(2), 513–529. https://doi.org/10.1534/genetics.116.191973
Dang, UJ and Golding, GB (2016), markophylo: Markov Chain Analysis on Phylogenetic Trees. Bioinformatics 32 (1): 130–132. https://doi.org/10.1093/bioinformatics/btv541
Dang, UJ, Browne, RP, and McNicholas, PD (2015), Mixtures of multivariate power exponential distributions. Biometrics 71(4), 1081–1089. https://doi.org/10.1111/biom.12351
Dang, UJ and McNicholas, PD (2015), Families of parsimonious finite mixtures of regression models. In: Morlini, I, Minerva T and Vichi, M, editors, Advances in Statistical Models for Data Analysis, Studies in Classification, Data Analysis, and Knowledge Organization. Springer International Publishing Switzerland, pp. 73–84. http://dx.doi.org/10.1007/978-3-319-17377-1_9
Dang, UJ and Bauch, CT (2011), Can interactions between timing of vaccine-altered influenza pandemic waves and seasonality in influenza complications lead to more severe outcomes?, PLoS ONE 6(8): e23580. https://doi.org/10.1371/journal.pone.0023580
Dang, U, & Bauch, CT (2010). A population biological approach to the collective dynamics of countries undergoing demographic transition. Journal of Theoretical Biology, 265(2), 167–176. https://doi.org/https://doi.org/10.1016/j.jtbi.2010.04.008
Software
Utkarsh J. Dang, Michael P. B. Gallaugher, Ryan P. Browne, and Paul D. McNicholas (2019). mixSPE: Mixtures of Power Exponential and Skew Power Exponential Distributions for Use in Model-Based Clustering and Classification. Package.
Utkarsh J. Dang and G. Brian Golding (2016). indelmiss: Insertion Deletion Analysis While Accounting for Possible Missing Data. Package.
Utkarsh J. Dang and G. Brian Golding (2015). markophylo: Markov Chain Models for Phylogenetic Trees. Package. Vignette
Non-refereed contributions
Dang, U. J. (2014). Mixtures of Power Exponential Distributions and Topics in Regression-based Mixture Models. University of Guelph.
Dang, U. J. (2011). Interactions Between Immunization Strategies and Pandemic Influenza Associated Severe Outcomes. University of Guelph.