p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL, Nature Metabolism, doi: org/10.1038/s42255-023-00957-x
Comparative Proteomics of ccRCC Cell Lines to Identify Kidney Cancer Progression Factors, Cancer Genomics & Proteomics, doi:10.21873/cgp.20480 ,
A Zwitterionic Detergent and Catalyst-Based Single-Cell Proteomics Using a Loss-Free Microhole-Collection Disc, Analytical Chemistry, doi: 10.1021/acs.analchem.4c00158
Casein kinase 2 complex: a central regulator of multiple pathobiological signaling pathways in Cryptococcus neoformans, Mbio, doi: 10.1128/mbio.03275-23
Deciphering microbiota-host interplay: bacterial metabolites and protein post-translational modifications, Life Medicine. doi: 10.1093/lifemedi/lnae003
Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations, Acta Pharmacologica Sinica, doi: 10.1038/s41401-024-01236-5.
Identification of a-Amanitin Effector Proteins in Hepatocytes by Limited Proteolysis-Coupled Mass Spectrometry, Chemico-Biological Interactions, doi: 10.1016/j.cbi.2023.110778
Global profiling of lysine acetylation and lactylation in Kupffer cells, Journal of Proteome Research, doi: 10.1021/acs.jproteome.3c00156
Using Comparative Proteomics to Identify Protein Signatures in Clear Cell Renal Cell Carcinoma, Cancer Genomics and Proteomics, doi.org/10.21873/cgp.20408
p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1, Nature Communications, doi: 10.1038/s41467-023-40597-z
Integrative profiling of lysine acylome in sepsis-induced liver injury, Journal of Proteome Research. doi: 10.1021/acs.jproteome.3c00130
Selective inhibitory effects of suberosin on CYP1A2 in human liver microsomes, Biopharmaceutics & Drug Disposition, doi: 10.1002/bdd.2370
Novel Time-dependent Multi-omics Integration to Explore Mechanisms of Disease Progression in sepsis-associated Liver Dysfunction, Genomics Proteomics Bioinformatics, doi: 10.1016/j.gpb.2023.04.002. Online ahead of print.
Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide. Ecotoxicology and Environmental Safety, 258 (2023) 114967, doi: 10.1016/j.ecoenv.2023.114967.
Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish. Journal of Hazardous Materials, 2023. 457: 131714; https://doi.org/10.1016/j.jhazmat.2023.131714
Identification of Histone Lysine Acetoacetylation as a Dynamic Post-Translational Modification Regulated by HBO1. Advanced Science, https://doi.org/10.1002/advs.202300032
SIRT5 Directly Inhibits the PI3K/AKT Pathway in Prostate Cancer Cell Line, Cancer Genomics Proteomics,. 2022 Jan-Feb;19(1):50-59. doi: 10.21873/cgp.20303.
SIRT5 Is the Desuccinylase of LDHA as Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer, Genomics Proteomics Bioinformatics, 2022 Mar 9;S1672-0229(22)00018-3. doi: 10.1016/j.gpb.2022.02.004. Online ahead of print.
Type 2 diabetes induced by changes in proteomic profiling of zebrafish chronically exposed to a mixture of organochlorine pesticides at low concentrations, Int J Environ Res Public Health, 2022 Apr 20;19(9):4991. doi: 10.3390/ijerph19094991.
Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells, Int J Mol Sci. 2022 Oct 14;23(20):12294. doi: 10.3390/ijms232012294.
Anti-metastatic effect of pyruvate dehydrogenase kinase 4 inhibition in bladder cancer via the ERK, SRC, and JNK pathways, Int J Mol Sci, 2022 Oct 31;23(21):13240. doi: 10.3390/ijms232113240.
Synergetic effects of concurrent chronic exposure to a mixture of OCPs and high-fat diets on type 2 diabetes and beneficial effects of caloric restriction in female zebrafish, J Hazard Mater, 2023 Mar 15;446:130659. doi: 10.1016/j.jhazmat.2022.130659. Epub 2022 Dec 23.
Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2, Cell Discovery, 2021 Dec 28;7(1):122. doi: 10.1038/s41421-021-00344-4.
Metabolism of Diterpenoids Derived from the Bark of Cinnamomum cassia in Human Liver Microsomes, Pharmaceutics, 2021 Aug 23;13(8):1316. doi: 10.3390/pharmaceutics13081316.
Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis, Int J Mol Sci, 2021 Aug 8;22(16):8529. doi: 10.3390/ijms22168529.
Integrated multi-omics analysis reveals the underlying molecular mechanism for developmental neurotoxicity of perfluorooctanesulfonic acid in zebrafish, Environ Int, 2021 Aug 4;157:106802. doi: 10.1016/j.envint.2021.106802.
Characterization of Novel Progression Factors in Castration-Resistant Prostate Cancer Based on Global Comparative Proteome Analysis, Cancers (Basel), 2021 Jul 8;13(14):3432. doi: 10.3390/cancers13143432..
In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics, Pharmaceutics, 2021 Jun 23;13(7):936. doi: 10.3390/pharmaceutics13070936.
Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis, Sci Rep, 2021 Jun 11;11(1):12374. doi: 10.1038/s41598-021-91664-8.
Nontargeted Metabolomics by High-Resolution Mass Spectrometry to Study the In Vitro Metabolism of a Dual Inverse Agonist of Estrogen-Related Receptors β and γ, DN203368, Pharmaceutics, 2021 May 31;13(6):776. doi: 10.3390/pharmaceutics13060776.
Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish, Journal of Hazardous Materials, 2021 Aug 15;416:125956. doi.org/10.1016/j.jhazmat.2021.125956.
Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy, Biomedicines, 2021 Apr 22;9(5):457. doi: 10.3390/biomedicines9050457.
Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish, Hum Mol Genet, 2021 Apr 27;30(5):331-342. doi: 10.1093/hmg/ddab033.
Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro, Toxins (Basel), 2021 Mar 9;13(3):197. doi: 10.3390/toxins13030197.
Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease, Int J Mol Sci, 2021 Mar 8;22(5):2707. doi: 10.3390/ijms22052707.
STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure, Nat Metab. 2021 Mar;3(3):428-441. doi: 10.1038/s42255-021-00362-2. Epub 2021 Mar 23.
Selective inhibitory effects of HYIpro-3-1 on CYP1A2 in human liver microsomes, Biopharm Drug Dispos. 2021 Jan;42(1):35-41. doi: 10.1002/bdd.2259
Identification of Novel Prognosis and Prediction Markers in Advanced Prostate Cancer Tissues Based on Quantitative Proteomics. Cancer Genomics Proteomics. 2020 Mar-Apr;17(2):195-208. doi: 10.21873/cgp.20180.
Patent '리코리시딘을 포함하는 ＵGＴ 활성 평가용 조성물 및 그의 용도', 대한민국, (출원:10-2018-0146551), 등록결정
Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice. Biopharm Drug Dispos. 2020 Jun 18. doi: 10.1002/bdd.2246. Online ahead of print.
In vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry. Xenobiotica. 2020 Apr;50(4):380-388. doi: 10.1080/00498254.2019.1636418. Epub 2019 Jul 5.
Deoxyshikonin reversibly inhibits cytochrome P450 2B6. Biopharm Drug Dispos. 2020 Apr;41(4-5):221-225. doi: 10.1002/bdd.2230. Epub 2020 May 22.
Characterization of osthenol metabolism in vivo and its pharmacokinetics. Xenobiotica. 2020 Jul;50(7):839-846. doi: 10.1080/00498254.2019.1705427. Epub 2019 Dec 27.