Toxicoproteomics is broadly defined as the global identification and characterization of proteins expressed in complex biological systems in response to a toxin, toxicant, or other adverse chemical or environmental stimulus. Integrative omics (multiomics) is a biological analysis approach in which the data sets are multiple "omes", such as the genome, proteome, transcriptome, epigenome,  and metabolome. Our research group develops the area of toxic proteomics, establishes an integrated analysis technique to identify the mechanism of toxicity from multi-omics information, and is carrying out a project using it.

Post-translational modification (PTM) is the covalent and generally enzymatic modification of proteins following protein biosynthesis. PTMs like phosphorylation, acetylation, SUMOylation, ubiquitination, and others account for the vast increase in proteome complexity. A variety of PTMs offer a way to facilitate rapid cellular changes by altering the structure and function of the protein. PTMs play a critical role in signal transduction, protein stability and turnover, protein-protein recognition and interaction, as well as spatial localization. In out lab, we conduct research to identify novel PTMs centered on lysine acylation and to identify the functions of protein PTMs.

Drug metabolism...