Research Highlight

Identification of histone lysine acetoacetylation as a dynamic post-translational modification regulated by HBO1

Yan Gao#, Xinlei Sheng,# Doudou Tan#, SunJoo Kim#, Soyoung Choi, Sanjita Paudel, Taeho Lee, Cong Yan, Minjia Tan, Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki, He Huang*, Yingming Zhao* and Sangkyu Lee*

Advanced Science. 2023 in pressed;  https://doi.org/10.1002/advs.202300032 

Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish

Eun Ki Min, Hyojin Lee, Eun Ji Sung, Seong Woo Seo, Myungha Song, Seungjun Wang, Seong Soon Kim, Myung Ae Bae, Tae-Young Kim*, Sangkyu Lee g*, Ki-Tae Kim*

Journal of Hazardous Materials 2023. 457: 131714; https://doi.org/10.1016/j.jhazmat.2023.131714 

Integrated multi-omics analysis reveals the underlying molecular mechanism for developmental neurotoxicity of perfluorooctanesulfonic acid in zebrafish

Hyojin Lee*, Eun Ji Sung ....... Tae-Young Kim#, Sangkyu Lee#, Ki-Tae Kim*

Environment International. 2021 Dec;157:106802. doi: 10.1016/j.envint.2021.106802. 

STK3/STK4 signalling in adipocytes regulates mitophagy and energy expenditure

Yoon Keun Cho*, Yeonho Son*, Abhirup Saha*, Doeun Kim* ...........  Sangkyu Lee#, James G. Granneman#  and Yun-Hee Lee#

Nature Metabolism. 2021 Mar;3(3):428-441. doi: 10.1038/s42255-021-00362-2. 

Metabolic regulation of gene expression by histone lactylation.

Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, Ding J, Czyz D, Hu R, Ye Z, He M, Zheng YG, Shuman HA, Dai L, Ren B, Roeder RG, Becker L, Zhao Y.

Nature. 2019 Oct;574(7779):575-580. doi: 10.1038/s41586-019-1678-1.