Bacterial infections and antimicrobial therapIES group
(BIAT group)
WELCOME To the
WELCOME To the
Torrents Lab webpage
Torrents Lab webpage
Bacterial Infections and antimicrobial therapy group (BIAT)
Bacterial Infections and antimicrobial therapy group (BIAT)
Dr. Eduard Torrents
Dr. Eduard Torrents
RESEARCH LINES and OUR GOALS:
RESEARCH LINES and OUR GOALS:
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
5. Developing new systems to mimic bacterial wound healing infections.
5. Developing new systems to mimic bacterial wound healing infections.
6. To develop bacterial vaccines.
6. To develop bacterial vaccines.
Selected publications (from the last 5 years):
Selected publications (from the last 5 years):
- Blanco-Cabra., Vega-Granados, K., Moya-Andérico, L., Vukomanovic, M., Parra, A., de Cienfuegos, LA., Torrents, E. (2019). Novel Oleanolic and Maslinic Acid Derivatives as a Promising Treatment against Bacterial Biofilm in Nosocomial Infections: An in Vitro and in Vivo Study. ACS Infectious Disease.
- Vukomanovic, M., Torrents, E. (2019). High time resolution and high signal-to-noise monitoring of the bacterial growth kinetics in the presence of plasmonic nanoparticles. Jounal of Nanobiotechnology. 17:21.
- Ohui, K., Afanasenko, E., Bacher, F., Lim Xue Ting, R., Zafar, A., Blanco-Cabra, N., Torrents, E., Dömötör, O., May, NV., Darvasiova, D., Enyedy, EA., Popović-Bijelić, A., Reynisson, J., Rapta, P., Babak, MV., Pastorin, G., Arion, VB. (2019). New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids as Potential Anticancer and Antibacterial Drugs. J. Med. Chemistry. 62(2):512-530.
- Miret, L., Baelo, A., Julián, E., Astola, J., Lobo-Ruiz, A., Albericio, F., and Torrents, E. (2018). Hydroxylamine derivatives as a new paradigm in the search of antibacterial agents. ACS Omega. 3: 17057-17069.
- Pujol, E., Blanco-Cabra, N., Julián, E., Leiva, R., Torrents, E* and Vázquez, S*. (2018). Pentafluorosulfanyl-containing triclocarban analogs with potent antimicrobial activity. Molecules. 23(11): 2853.
- Lozano, H., Fabregas, R., Blanco-Cabra,N., Millán-Solsona, R., Torrents, E., Fumagalli, L., Gomila, G. (2018). Dielectric constant of flagellin proteins measured by scanning dielectric microscopy. Nanoscale. 10:19188-19194.
- Crespo, A., Blanco-Cabra, N., Torrents, E. (2018). Aerobic vitamin B12 biosynthesis is essential for Pseudomonas aeruginosa class II ribonucleotide reductase activity during planktonic and biofilm growth. Frontiers in Microbiology. 9: 986.
- Crespo, A., Pedraz, L., Van der Hofstadt., Gomilla, G. and Torrents, E. (2017). Regulation of ribonucleotide synthesis by the Pseudomonas aeruginosa two-component system AlgR in response to oxidative stress. Scientific Reports 7: 17892.
- Crespo, A., Gavaldà, J., Julián, E., Torrents, E. (2017). A single point mutation in class III ribonucleotide reductase promoter renders Pseudomonas aeruginosa PAO1 inefficient for anaerobic growth and infection. Scientific Reports 7: 13350.
- Baelo, A., Levato, R., Julián, E., Crespo, A., Astola, J., Gavaldà, J., Engel, E., Mateos-Timoneda, A., Torrents, E. (2015). Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections. Journal Controlled Release. 209:150-158.
- Dreux, N., Cendra, MM., Massier, S., Darfeuille-Michaud, A., Barnich, N., Torrents, E. (2015). Ribonucleotide reductase NrdR as a novel regulator for motility and chemotaxis during adherent-invasive Escherichia coli infection. Infection and Immunity. 83(4):1305-1317.
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