Bacterial infections and antimicrobial therapIES group
WELCOME To the
Torrents Lab webpage
RESEARCH LINES and OUR GOALS:
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
5. Developing new systems to mimic bacterial wound healing infections.
6. To develop bacterial vaccines.
7. Developing phage therapy to treat chronic bacterial infections.
Selected publications (from the last 3 years):
Moya-Andérico, L., Vukomanovic, M., Cendra, MdM., Segura-Feliu, M., Gil, V., Del Río, JA. and Torrents, E. (2021). Utility of Galleria mellonella larvae for evaluating nanoparticle toxicology. Chemosphere. 266:129235
Moya-Andérico, L., Admella, J. and Torrents, E. (2021). A clearing protocol for Galleria mellonella larvae: visualization of internalized fluorescent nanoparticle. New Biotechnology. 60: 20-26.
Moya-Andérico, L., Admella, J., Fernandes, R, and Torrents, E. (2020). Monitoring gene expression during Galleria mellonella bacterial infection. Microorganisms. 8:1798. Included as a Cover for the Issue 11 Volumen 8 (2020)
Cendra, MdM., Torrents, E. (2020). Differential adaptability between reference strains and clinical isolates of Pseudomonas aeruginosa into the lung epithelium intracellular lifestyle. Virulence. 11(1): 862-876.
Blanco-Cabra, N., Paetzold, B., Ferrar, T., Mazzolini, R., Torrents, E., Serrano, L., Lluch-Senar, M. (2020). Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms. Scientific Reports. 10: 9390.
Pedraz, L., Blanco-Cabra, Torrents, E. (2020). Gradual adaptation of facultative anaerobic pathogens to microaerobic and anaerobic conditions. The FASEB Journal. 34(2):2912-2928.
Blanco-Cabra., Vega-Granados, K., Moya-Andérico, L., Vukomanovic, M., Parra, A., de Cienfuegos, LA., Torrents, E. (2019). Novel Oleanolic and Maslinic Acid Derivatives as a Promising Treatment against Bacterial Biofilm in Nosocomial Infections: An in Vitro and in Vivo Study. ACS Infectious Disease. 5(9):1581-1589.
Vukomanovic, M., Torrents, E. (2019). High time resolution and high signal-to-noise monitoring of the bacterial growth kinetics in the presence of plasmonic nanoparticles. Jounal of Nanobiotechnology. 17:21.
Crespo, A., Blanco-Cabra, N., Torrents, E. (2018). Aerobic vitamin B12 biosynthesis is essential for Pseudomonas aeruginosa class II ribonucleotide reductase activity during planktonic and biofilm growth. Frontiers in Microbiology. 9: 986.