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WELCOME To the
WELCOME To the
Torrents Lab webpage
Torrents Lab webpage
Bacterial Infections and antimicrobial therapy group (BIAT)
Bacterial Infections and antimicrobial therapy group (BIAT)
Dr. Eduard Torrents (ICREA Acadèmia 2025)
Dr. Eduard Torrents (ICREA Acadèmia 2025)
RESEARCH LINES and OUR GOALS:
RESEARCH LINES and OUR GOALS:
RESEARCH LINES and OUR GOALS:
RESEARCH LINES and OUR GOALS:
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
5. Developing new systems to mimic polymicrobial bacterial infections.
5. Developing new systems to mimic polymicrobial bacterial infections.
6. To develop bacterial vaccines.
6. To develop bacterial vaccines.
7. Developing phage therapy to treat chronic bacterial infections.
7. Developing phage therapy to treat chronic bacterial infections.
Roncero-Carol, J., Olaizolam J., Arán, B., Mularoni, LS., Miret Cuesta, M., Blanco, N., Casals, M., Rumbo, M., Solé, M., Ojosnegros, S., Alsina, B., Torrents, E., Veiga, A., Irimia. M. Hoijman, E. (2025). Epithelial cells provide immunocompetence to the early embryo for bacterial clearance. Cell Host & Microbe 33: 1-15.
Campo-Pérez, V., Julián, E. and Torrents, E. (2025). Interplay of Mycobacterium abscessus and Pseudomonas aeruginosa in coinfection: Biofilm dynamics and host immune response. Virulence. 16(1): 2493221
Alcàcer-Almansa, J., Blanco-Cabra, N., Torrents, E. (2025). Burkholderia cenocepacia and Pseudomonas aeruginosa in dual-species models: Insights into population distribution, antibiotic susceptibility and virulence. Virulence. 16(1): 2494039.
Arévalo-Jaimes, VB., Admella, J. and Torrents, E. (2025). Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms. Communications Biology. 8:160.
Arévalo-Jaimes, BV, Salinas-Pena, M., Ponte, I., Jordan, A., Roque, A, Torrents, E. (2024). Antimicrobial and antibiofilm activity of human recombinant H1 histones against bacterial infections. mSystems. 9:e00704-24.
Blanco-Cabra, N., Alcàcer-Almansa, J., Admella, J., Arévalo-Jaimes, BV. and Torrents, E. (2024). Nanomedicine against biofilm infections: a roadmap of challenges and limitations. WIREs Nanomedicine and Nanobiotechnology. 16:e1944.
Admella, J. and Torrents, E. (2023). Investigating Bacterial Infections in Galleria mellonella Larvae: Insights into Pathogen Dissemination and Behavior. Journal of Invertebrate Pathology. 200:107975.
Alba Rubio-Canalejas, A., Pedraz, L., Torrents, E. (2023). ReViTA: A novel in vitro transcription system to study gene regulation. New Biotechnology. 76:41-48.
Rubio-Canalejas, A., Admella, J., Pedraz, L. and Torrents, E. (2023). Pseudomonas aeruginosa nonphosphorylated AlgR induces ribonucleotide reductase expression under oxidative stress infectious conditions. mSystems. 8(2):e01005-22.
Alcàcer-Almansa, J., Arévalo-Jaimes, BV., Blanco-Cabra, N. and Torrents, E. (2023). Methods for studying biofilms: microfluidics and translation into the clinical context. Methods in Microbiology. Biofilm. Vol 53: 195-233.
Rubio-Canalejas, A., Herbera, S., Baelo, A., Blanco-Cabra, N., Vukomanovic, M., Torrents, E. (2022). 3D spatial organization and improved antibiotic treatment of a Pseudomonas aeruginosa - Staphylococcus aureus wound biofilm by nanoparticle enzyme delivery. Frontiers in Microbiology. 13: 959156.
Vukomanovic, M., Gazvoda, L., Kurtjak, M., Hrescak, J., Jaklic, B., Moya-Andérico, L., Cendra, MdM., Torrents, E. (2022). Development of a ternary cyclodextrin–arginine–ciprofloxacin complex with enhanced stability. Communications Biology. 5:1234.
Admella, J. and Torrents, E. (2022). A straightforward method for the isolation and cultivation of Galleria mellonella hemocytes. International Journal of Molecular Sciences. 23: 13483.
García-Díaz, M., Cendra, MdM., Alonso, R., Urdániz, M., Torrents, E. and Martínez, E. (2022). Mimicking the intestinal host-pathogen interactions in a 3D in vitro model: the role of the mucus layer. Pharmaceutics. 14:1552.
Blanco-Cabra, N., Movellan, J., Marradi, M., Gracia, R., Salvador, C., Dupin, D., Loinaz, I., Torrents, E. (2022). Dextran-based single-chain nanoparticles improve the tobramycin and DNase I activity against mature biofilms by interacting with the extracellular matrix. npj Biofilms and Microbiomes. 8:52.
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