Bacterial infections and antimicrobial therapIES group
(BIAT group)
WELCOME To the
Torrents Lab webpage
Bacterial Infections and antimicrobial therapy group (BIAT)
Dr. Eduard Torrents
RESEARCH LINES and OUR GOALS:
RESEARCH LINES and OUR GOALS:
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
5. Developing new systems to mimic bacterial wound healing infections.
6. To develop bacterial vaccines.
7. Developing phage therapy to treat chronic bacterial infections.
Selected publications (from the last 3 years): Check here complete list
Blanco-Cabra, N., Movellan, J., Marradi, M., Gracia, R., Salvador, C., Dupin, D., Loinaz, I., Torrents, E. (2022). Dextran-based single-chain nanoparticles improve the tobramycin and DNase I activity against mature biofilms by interacting with the extracellular matrix. npj Biofilms and Microbiomes. 8:52.
Guallar-Garrido, S., Almiñana-Rapún, F., Campo-Pérez, V., Torrents,E., Luquin, M., and Julián, E. (2022). BCG Substrains Change Their Outermost Surface as a Function of Growth Media. Vaccines 10: 40.
Lozano, H., Millan-Solsona, R., Blanco-Cabra, N., Fabregas, R., Torrents, E., Gomila, G. (2021). Electrical Properties of Outer Membrane Extensions from Shewanella oneidensis MR-1. Nanoscale 13:18754-762.
Vukomanovic, M., Cendra, MdM., Baelo, A. and Torrents, E. (2021). Nano-engineering stable contact-based antimicrobials: chemistry at the interface between nano-gold and bacteria. Colloids and Surfaces B: Biointerfaces. 208: 112083.
Blanco-Cabra, N., López-Martínez, MJ., Arévalo-Jaimes, BV., Martín-Gómez, MT., Samitier, J. and Torrents, E. (2021). A new BiofilmChip device as a personalized solution for testing biofilm antibiotic resistance. npj Biofilms and Microbiomes 7:62.
Cendra, MdM., Torrents, E. (2021). Pseudomonas aeruginosa biofilms and their partners in crime. Biotechnology Advances. 49:107734.
Vilela, D., Blanco-Cabra, N., Eguskiza, A., Hortelao, AC., Torrents, E., Sanchez, S. (2021). Drug-Free Enzyme-Based Bactericidal Nanomotors against Pathogenic Bacteria. ACS Appl. Mater. Interfaces. 13, 13, 14964–14973.
Campo-Pérez, V., Cendra, MdM., Julián, E., Torrents, E. (2021). Easily applicable modifications to electroporation conditions improve the transformation efficiency rates for rough morphotypes of fast-growing mycobacteria. New Biotechnology. 63: 10-18.
Abdelrahman , F., Easwaran, M., Daramola, OI., Ragab, S., Lynch, S., Oduselu, TJ., Khan, FM., Ayobami, A., Adnan, F., Torrents, E., Sanmukh, S. and El-Shibiny, A. (2021). Phage-Encoded Endolysins. Antibiotics. 10: 124.
Moya-Andérico, L., Vukomanovic, M., Cendra, MdM., Segura-Feliu, M., Gil, V., Del Río, JA. and Torrents, E. (2021). Utility of Galleria mellonella larvae for evaluating nanoparticle toxicology. Chemosphere. 266:129235
Moya-Andérico, L., Admella, J. and Torrents, E. (2021). A clearing protocol for Galleria mellonella larvae: visualization of internalized fluorescent nanoparticle. New Biotechnology. 60: 20-26.
Moya-Andérico, L., Admella, J., Fernandes, R, and Torrents, E. (2020). Monitoring gene expression during Galleria mellonella bacterial infection. Microorganisms. 8:1798. Included as a Cover for the Issue 11 Volumen 8 (2020)
Cendra, MdM., Torrents, E. (2020). Differential adaptability between reference strains and clinical isolates of Pseudomonas aeruginosa into the lung epithelium intracellular lifestyle. Virulence. 11(1): 862-876.
Blanco-Cabra, N., Paetzold, B., Ferrar, T., Mazzolini, R., Torrents, E., Serrano, L., Lluch-Senar, M. (2020). Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms. Scientific Reports. 10: 9390.
Pedraz, L., Blanco-Cabra, Torrents, E. (2020). Gradual adaptation of facultative anaerobic pathogens to microaerobic and anaerobic conditions. The FASEB Journal. 34(2):2912-2928.
Cendra, MdM., Blanco-Cabra, N., Pedraz, L., Torrents, E. (2019). Facing the in vitro challenge in Pseudomonas aeruginosa and Staphylococcus aureus coexistence. Scientific Reports. 9(1):16284.
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