Bacterial infections and antimicrobial therapIES group
WELCOME To the
Torrents Lab webpage
RESEARCH LINES and OUR GOALS:
1. To understand the molecular basis of transcriptional regulation of the different genes involved in the bacterial DNA synthesis.
2. Unravel the molecular mechanisms of bacterial virulence and biofilm formation. To understand the physiology of bacteria growing in a biofilm.
3. New drug delivery systems to kill bacteria living in biofilms - Treatment of chronic bacterial infections.
4. Discovery of new antimicrobial therapies to combat bacterial infections by the application of nanomedicine techniques.
5. Developing new systems to mimic bacterial wound healing infections.
6. To develop bacterial vaccines.
Selected publications (from the last 3 years):
Cendra, MdM., Torrents, E. (2020). Differential adaptability between reference strains and clinical isolates of Pseudomonas aeruginosa into the lung epithelium intracellular lifestyle. Virulence. 11(1): 862-876.
Blanco-Cabra, N., Paetzold, B., Ferrar, T., Mazzolini, R., Torrents, E., Serrano, L., Lluch-Senar, M. (2020). Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms. Scientific Reports. 10: 9390.
Bach-Griera, M., Campo-Pérez, V., Barbosa, S., Traserra, S., Guallar- Garrido, S., Moya-Andérico, L., Herrero-Abadía, P., Luquin, M., Rabanal, RM., Torrents, E., Julián, E. (2020). Mycolicibacterium brumae Is a Safe and Non-Toxic Immunomodulatory Agent for Cancer Treatment. Vaccine. 8(2):E198. doi: 10.3390/vaccines8020198.
Pedraz, L., Blanco-Cabra, Torrents, E. (2020). Gradual adaptation of facultative anaerobic pathogens to microaerobic and anaerobic conditions. The FASEB Journal. 34(2):2912-2928.
Blanco-Cabra., Vega-Granados, K., Moya-Andérico, L., Vukomanovic, M., Parra, A., de Cienfuegos, LA., Torrents, E. (2019). Novel Oleanolic and Maslinic Acid Derivatives as a Promising Treatment against Bacterial Biofilm in Nosocomial Infections: An in Vitro and in Vivo Study. ACS Infectious Disease. 5(9):1581-1589.
Vukomanovic, M., Torrents, E. (2019). High time resolution and high signal-to-noise monitoring of the bacterial growth kinetics in the presence of plasmonic nanoparticles. Jounal of Nanobiotechnology. 17:21.
Lozano, H., Fabregas, R., Blanco-Cabra,N., Millán-Solsona, R., Torrents, E., Fumagalli, L., Gomila, G. (2018). Dielectric constant of flagellin proteins measured by scanning dielectric microscopy. Nanoscale. 10:19188-19194.
Crespo, A., Blanco-Cabra, N., Torrents, E. (2018). Aerobic vitamin B12 biosynthesis is essential for Pseudomonas aeruginosa class II ribonucleotide reductase activity during planktonic and biofilm growth. Frontiers in Microbiology. 9: 986.
Crespo, A., Pedraz, L., Van der Hofstadt., Gomilla, G. and Torrents, E. (2017). Regulation of ribonucleotide synthesis by the Pseudomonas aeruginosa two-component system AlgR in response to oxidative stress. Scientific Reports 7: 17892.
Crespo, A., Gavaldà, J., Julián, E., Torrents, E. (2017). A single point mutation in class III ribonucleotide reductase promoter renders Pseudomonas aeruginosa PAO1 inefficient for anaerobic growth and infection. Scientific Reports 7: 13350.