Major Publications

1. Gupta K, Chen D, Wells RG. Microcystin-RR is a biliary toxin selective for neonatal extrahepatic cholangiocytes. JHEP Reports. 2025;7(1):101218. doi.org/10.1016/j.jhepr.2024.101218     

  PMID: 39687604; Impact factor: 7.5 

2. Gupta K, Llewellyn J, Roberts E, Liu C, Naji A, Assoian RK, Wells RG. Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics. JHEP Reports. 2025;7(1):101215. doi.org/10.1016/j.jhepr.2024.101215

  PMID: 39717503; Impact factor: 7.5  

3. Gupta K, Xu JP, Diamond T, de Jong IEM, Glass A, Llewellyn J, Theise ND, Waisbourd-Zinman O, Winkler JD, Behrens EM, Mesaros C, Wells RG. Low-dose biliatresone treatment of pregnant mice causes subclinical biliary  disease in their offspring: Evidence for a spectrum of neonatal injury. PLoS One. 2024;19(4):e0301824. doi:10.1371/journal.pone.0301824

  PMID: 38578745; Impact factor: 2.6 

4. Gupta K, Ng IC, Balachander GM, Nguyen BP, Tucker-Kellogg L, Low BC, Yu H. Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel. Biomaterials. 2020;259:120283. doi:10.1016/j.biomaterials.2020.120283

           PMID: 32827796; Impact factor: 12.9 

5. Luo X, Gupta K, Ananthanarayanan A, Wang Z, Xia L, Li A, Sakban RB, Liu S, Yu H. Directed Differentiation of Adult Liver Derived Mesenchymal Like Stem Cells into Functional Hepatocytes. Sci Rep. 2018;8(1):2818. doi:10.1038/s41598-018-20304-5

  PMID: 29434311; Impact factor: 3.9  

6. Dasgupta S, Gupta K, Zhang Y, Viasnoff V, Prost J. Physics of lumen growth. Proc Natl Acad Sci U S A. 2018;115(21):E4751-E4757. doi:10.1073/pnas.1722154115

       PMID: 29735699; Impact factor: 9.4 

7. Gupta K, Li Q, Fan JJ, Fong ELS, Song Z, Mo S, Tang H, Ng IC, Ng CW, Pawijit P, Zhuo S, Dong CY, Low BC, Wee A, Dan YY, Kanchanawong P, So P, Viasnoff V, Yu H. Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis. J Hepatol. 2017;66(6):1231-1240. doi:10.1016/j.jhep.2017.01.026

  PMID: 28189756; Impact factor: 33 

8. Gupta K, Jana AK, Kumar S, Jana MM. Solid state fermentation with recovery of Amyloglucosidase from extract by direct immobilization in cross linked enzyme aggregate for starch hydrolysis. Biocatal Agric Biotechnol. 2015;4(4):486-492. doi:10.1016/j.bcab.2015.07.007 

       Link; Impact factor: 3.8

9. Gupta K, Jana AK, Kumar S, Maiti M. Immobilization of amyloglucosidase from SSF of Aspergillus niger by crosslinked enzyme aggregate onto magnetic nanoparticles using minimum amount of carrier and characterizations. J Mol Catal B Enzym. 2013;98:30-36. doi:10.1016/j.molcatb.2013.09.015

       Link; Impact factor (2016): 2.2.

10. Gupta K, Jana AK, Kumar S, Maiti M. Immobilization of α-amylase and amyloglucosidase onto ion-exchange resin beads and hydrolysis of natural starch at high concentration. Bioprocess Biosyst Eng. 2013;36(11):1715-1724. doi:10.1007/s00449-013-0946-y

  PMID:  23572179; Impact factor: 3.6. 

Other Publications

1. Li H, Gupta K, Wang Z, Llewellyn J, Jin H, Tenney S, Wells RG, Foston M. Understanding sub-cellular mechanochemical correlations of the neonatal extrahepatic bile duct extracellular matrix by atomic force microscope-Infrared spectroscopy. Anal Chim Acta. 2026;1393:345175. doi.org/10.1016/j.aca.2026.345175

  PMID: 41708237; Impact factor: 6.0 

2. Ordner J, Narula N, Chiriboga L, Zeck B, Majd M, Gupta K, Gaglia R, Zhou F, Moreira A, Iman R, Ko JP, Le L, Wells RG, Theise ND. Continuity of interstitial spaces within and outside the human lung. J Anat. 2025;247(5):1059-1068. doi.org/10.1111/joa.14280

  PMID: 40442920; Impact factor: 1.9   

3. Du Y, de Jong IEM, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck WJ, Wells RG. Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease. Biofabrication. 2023;16(1). doi:10.1088/1758-5090/ad0261

  PMID: 37820623; Impact factor: 8.0  

4. de Jong IEM, Hunt ML, Chen D, Du Y, Llewellyn J, Gupta K, Li D, Erxleben D, Rivas F, Hall AR, Furth EE, Naji A, Liu C, Dhand A, Burdick JA, Davey MG, Flake AW, Porte RJ, Russo PA, Gaynor JW, Wells RG. A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia. J Hepatol. 2023;79(6):1396-1407. doi:10.1016/j.jhep.2023.08.010

  PMID: 37611641; Impact factor: 33 

5. Li Z, Chen Z, Gao Y, Xing Y, Zhou Y, Luo Y, Xu W, Chen Z, Gao X, Gupta K, Anbalakan K, Chen L, Liu C, Kong J, Leo HL, Hu C, Yu H, Guo Q. Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment. Biomaterials. 2022;283:121426. doi:10.1016/j.biomaterials.2022.121426

  PMID: 35240471; Impact factor: 12.9 

6. O’keeffe A, Hale C, Cotton JA, Yardley V, Gupta K, Ananthanarayanan A, Murdan S, Croft SL. Novel 2D and 3D assays to determine the activity of anti-leishmanial drugs. Microorganisms. 2020;8(6). doi:10.3390/microorganisms8060831

  PMID: 32492796; Impact factor: 4.2  

7. Tasnim F, Singh NH, Tan EKF, Xing J, Li H, Hissette S, Manesh S, Fulwood J, Gupta K, Ng CW, Xu S, Hill J, Yu H. Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing. Sci Rep. 2020;10(1):4768. doi:10.1038/s41598-020-61699-4

  PMID: 32179810 ; Impact factor: 3.9 

8. Sun M, Wong JY, Nugraha B, Ananthanarayanan A, Liu Z, Lee F, Gupta K, Fong ELS, Huang X, Yu H. Cleavable cellulosic sponge for functional hepatic cell culture and retrieval. Biomaterials. 2019;201:16-32. doi:10.1016/j.biomaterials.2019.01.046

  PMID: 30784769 ; Impact factor: 12.9  

9. Chua ACY, Ananthanarayanan A, Ong JJY, Wong JY, Yip A, Singh NH, Qu Y, Dembele L, McMillian M, Ubalee R, Davidson S, Tungtaeng A, Imerbsin R, Gupta K, Andolina C, Lee F, S-W Tan K, Nosten F, Russell B, Lange A, Diagana TT, Rénia L, Yeung BKS, Yu H, Bifani P. Hepatic spheroids used as an in vitro model to study malaria relapse. Biomaterials. 2019;216:119221. doi:10.1016/j.biomaterials.2019.05.032

  PMID: 31195301; Impact factor: 12.9  

Reviews

10. Chua ACY, Ananthanarayanan A, Ong JJY, Wong JY, Yip A, Singh NH, Qu Y, Dembele L, McMillian M, Ubalee R, Davidson S, Tungtaeng A, Imerbsin R, Gupta K, Andolina C, Lee F, S-W Tan K, Nosten F, Russell B, Lange A, Diagana TT, Rénia L, Yeung BKS, Yu H, Bifani P. Hepatic spheroids used as an in vitro model to study malaria relapse. Biomaterials. 2019;216:119221. doi:10.1016/j.biomaterials.2019.05.032

  PMID: 31195301; Impact factor: 12.9  

book chapter

11. Chua ACY, Ananthanarayanan A, Ong JJY, Wong JY, Yip A, Singh NH, Qu Y, Dembele L, McMillian M, Ubalee R, Davidson S, Tungtaeng A, Imerbsin R, Gupta K, Andolina C, Lee F, S-W Tan K, Nosten F, Russell B, Lange A, Diagana TT, Rénia L, Yeung BKS, Yu H, Bifani P. Hepatic spheroids used as an in vitro model to study malaria relapse. Biomaterials. 2019;216:119221. doi:10.1016/j.biomaterials.2019.05.032

  PMID: 31195301; Impact factor: 12.9  

research talk

1. 1. 1. " Bile duct on a chip and its applications." Brainstorming Session on Organ-on-Chip: A Preclinical Device for Diagnosis, Drug Discovery, and Development Platform”, jointly organized by ILBS Delhi and NIPER Guwahati at NIPER, Guwahati, 12th January 2025.

      2. "Microcystin-RR Produced by Blue Green Algae Causes Neonatal Extrahepatic Bile Duct Damage" at GRS Mycotoxins and Phycotoxins, Easton, 16-17 June 2023.

      3. "Hepatobiliary mechanics." International RB Memorial conference on Translational Research in Medicine, IIT Bombay, 19th April 2022.

      4. "Regulation of Bile Canaliculi Dynamics in Physiological and Cholestatic Conditions." at Mechanobiology in Health and Disease Symposium, Singapore, 2018.

Poster presentation

1. Gupta K, Wells RG. "Microcystin-RR Produced by Blue Green Algae Causes Neonatal Extrahepatic Bile Duct Damage." Poster presentation at GRC Mycotoxins and Phycotoxins, Easton, 18-23 June 2023.

2. Gupta K, Wells RG. "Toxins Produced by Blue Green Algae Cause Neonatal Extrahepatic Bile Duct Damage." Poster presentation at Center of Excellence in Environmental Toxicology (CEET) Seventeenth Annual Symposium On Climate Change And Human Health, Philadelphia, 18 November 2022.

3. Gupta K, Wells RG. “Microcystin RR cause extrahepatic bile duct damage specifically in neonates”. Poster presentation at 22nd Annual NIH Center for Molecular Studies in Digestive and Liver Diseases Symposium, Philadelphia, 31 October 2022.

4. Gupta K, Wells RG. "Microcystin RR Causes Extrahepatic Bile Duct Damage Specifically in Neonates," Poster presentation at the Tissue Fibrosis and Repair: Mechanisms, Human Disease and Therapies Keystone Symposia, Keystone, 12-17 June 2022.

5. Gupta K, Ng I C, Yu H. "Bile Canaliculi Contractility Is Regulated by Canalicular Pressure Sensing via Piezo1." Poster presentation at the 63rd meeting of Biophysical Society, Baltimore, 2019. Awarded “2019 BPS Travel Award” of 750 USD

6. Gupta K, Ng I C, Yu H. "Mechanical Regulation of Cholestatic Diseases via Mechanosensitive Channels." Poster presentation at MBI 10th Anniversary Conference, Singapore, 2018.

7. Gupta K, Ng I C, Yu H. "Hunt for the Calcium Store Driving Bile Canalicular Contractions." Poster presentation at EMBO Workshop on Membrane Contact Sites in Health and Disease, Arosa, 2018. Awarded "EMBO travel Award" of 550 CHF

8. Gupta K, Ng I C, Yu H. "Mechanosensitive Shuttling of Calcium Across Bile Canaliculi Drives Canalicular Contraction." Poster presentation at the XV International Meeting of the European Calcium Society, Hamburg, 2018.

9. Gupta K, Li Q, Yu H. "Regulation of Bile Canaliculi Dynamics by Actomyosin Cytoskeleton." Poster presentation at the International Congress of Cell Biology, Hyderabad, 2018. Awarded "The Travel APOCB Award" of 1500 SGD

10. Gupta K, Li Q, Yu H. "Blebbing and Budding: Early Canalicular Response to Altered Canalicular Pressure in Obstructive Cholestasis." Poster presentation at The 26th Conference of the Asian Pacific Association for the Study of the Liver, Shanghai, 2017.

11. Gupta K, Li Q, Yu H. "Understanding the Actomyosin Network Response to Changes in Canalicular Pressure." Poster presentation at EMBO | EMBL Symposium: Actin in Action: from Molecules to Cellular Functions, Heidelberg, 2016. Awarded EMBL Advanced Training Centre Corporate Partnership Program Fellowship of 500 Euro