Our research goal is to establish a rigorous program devoted to the development, implementation, and mechanistic evaluation of novel approaches to assay and understand cholestatic liver disease
-Assay development for hepatocellular cholestasis
-Assay development for ductular cholestasis
-Immune cells in drug-induced ductular cholestasis: duct-on-a-chip
-Investigate the impact of stretching on neonatal EHBD cholangiocyte susceptibility
-Toxin-induced biliary atresia and genetical susceptibility
-The role of mechanics on maintenance of hepatocyte organoid differentiation.
-Regulating lumen budding using engineered geometrical patterns.
-Developing methodology to obtain patient-specific liver cells.
-Developing personalised cholestatic assays.
-Developing personalised therapeutics for cholestatic conditions