Publications

1. Jeong, J.*, Kwon, K.*, Geisseova, T.K., Lee, J., Kwon, T.**, and Lim, C.** (2024). Drosulfakinin signaling encodes early-life memory for adaptive social plasticity. bioRxiv https://doi.org/10.1101/2024.04.08.588562. *co-first authors; **co-corresponding authors. [bioRkiv]


47. Petrauskas, A.*, Fortunati, D.L.*, Kandi, A.R., Pothapragada, S.S., Agrawal, K., Singh, A., Huelsmeier, J., Hillebrand, J., Brown, G., Chaturvedi, D., Lee, J., Lim, C., Auburger, G., VijayRaghavan, K., Ramaswami, M.**, and Bakthavachalu, B.**  (2024). Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation. PLOS Genetics 20, e1011251. *co-first authors; **co-corresponding authors. [PubMed][OPEN Access][bioRxiv]

46. Ku, J.*, Lee, K.*, Ku, D., Kim, S., Lee, J., Bang, H., Kim, N., Do, H., Lee, H., Lim, C., Han, J., Lee, Y.-s.**, and Kim, Y.** (2024). Alternative polyadenylation determines the functional landscape of inverted Alu repeats. Molecular Cell 84, 1062-1077. *co-first authors; **co-corresponding authors. [PubMed]

45. Lee, H. and Lim, C. (2023). Circadian gating of light-induced arousal in Drosophila sleep. Journal of Neurogenetics 37, 36-46. [PubMed] (as a part of the special issue: History of Drosophila neurogenetic research in South Korea)

44. Park, D., Yu, Y., Kim, J.-H., Lee, J., Park, J., Hong, K., Seo, J.-K., Lim, C.**, and Min, K.-T.** (2023). Suboptimal mitochondrial activity facilitates nuclear heat shock responses for proteostasis and genome stability. Molecules and Cells  46, 374-386. **co-corresponding authors.  [PubMed][OPEN Access] 

43. Lee, S.*, Park, D.*, Lim, C.**, Kim, J.-I.**, and Min, K.-T.** (2022). mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth. BMC Biology 20, 12. *co-first authors; **co-corresponding authors. [PubMed][OPEN Access][bioRxiv]

42. Park, J.*, Chang, J.*, Hwang, H.J., Jeong, K., Lee, H.-J, Ha, H., Park, Y., Lim, C., Woo, J.-S., and Kim, Y.K. (2021). The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins. Nucleic Acids Research 49, 12517-12534. *co-first authors. [PubMed][OPEN Access]

41. Lee, J.*, Lim, C.*, Han, T.-H., Andreani, T., Moye, M., Curran, J., Johnson, E., Kath, W. L., Diekman, C.O., Lear, B.C., and Allada, R. (2021). The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms. Proc Natl Acad Sci USA 118, e2110767118. *co-first authors. [PubMed][OPEN Access]

40. Park, J.*, Lee, J.*, Kim, J.-H., Lee, J., Park, H., and Lim, C. (2021). ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Nucleic Acids Research 49, 11294-11311. *co-first authors.  [PubMed][OPEN Access]

39. Jeong, J., Lee, J., Kim, J.-H., and Lim, C. (2021). Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. PLOS Genetics 17, e1009871. [PubMed][OPEN Access] 

38. Park, J.*, Park, J.*, Lee, J., and Lim, C. (2021). The trinity of ribosome-associated quality control and stress signaling for proteostasis and neuronal physiology. BMB Reports 54, 439-450. *co-first authors. [PubMed][OPEN Access]

37. Lee, J., Park, J., Kim, J.-H., Lee, G., Park, T.-E., Yoon, K.-J., Kim, Y.K., and Lim, C. (2020). LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient. PLOS Biology 18, e3001002. [PubMed][OPEN Access]

36. Kanaya, H.J., Park, S.*, Kim, J.-H.*, Kusumi, J., Krenenou, S., Sawatari, E., Sato, A., Lee, J., Bang, H., Kobayakawa, Y., Lim, C.**, and Itoh, T.Q.** (2020). A sleep-like state in Hydra unravels conserved sleep mechanisms during the evolutionary development of the central nervous system. Science Advances 6, eabb9415. *co-second authors; **co-corresponding authors. [PubMed][OPEN Access]

35. Kim, J.-H.*, Ki, Y.*, Lee, H., Hur, M.S., Baik, B., Hur, J.-H., Nam, D., and Lim, C. (2020). The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission. Communications Biology 3, 174. *co-first authors. [PubMed][OPEN Access]

34. Kwon, P.K., Lee, K.-H., Kim, J.-H., Tae, S., Ham, S., Jeong, Y.-H., Kim, S.W., Kang, B., Kim, H.-M., Choi, J.-H., Yi, H., Ku, H.-O., Roh, T.-Y., Lim, C., and Kim, K.-T. (2020). hnRNP K supports high-amplitude D site-binding protein mRNA oscillation to sustain circadian rhythms. Molecular and Cellular Biology 40, e00537-19. [PubMed]

33. Xu, F., Kula-Eversole, E., Iwanaszko, M., Lim, C., and Allada, R. (2019). Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons. PLOS Genetics 15, e1008356. [PubMed][OPEN Access]

32. Ki, Y. and Lim, C. (2019). Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. eLife 8, e40593. [PubMed][OPEN Access]

31. Ri, H.*, Lee, J.*, Sonn, J.Y., Yoo, E., Lim, C.**, and Choe, J.** (2019). Drosophila CrebB is a substrate of the nonsense-mediated mRNA decay pathway that sustains circadian behaviors. Molecules and Cells 42, 301-312. *co-first authors; **co-corresponding authors. [PubMed][OPEN Access]

30. Sonn, J.Y.*, Lee, J.*, Sung, M.K., Ri, H., Choi, J.K., Lim, C.**, and Choe, J.** (2018). Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Proc Natl Acad Sci USA 115, 7129-7134. *co-first authors; **co-corresponding authors. [PubMed][OPEN Access]

29. Lee, J.*, Kim, M.*, Itoh, T.Q., and Lim, C. (2018). Ataxin-2: a versatile post-transcriptional regulator and its implication in neural function. Wiley Interdisciplinary Reviews RNA 9, e1488. *co-first authors. [PubMed]

28. Kweon, S.H., Lee, J., Lim, C.**, and Choe, J.** (2018). High-amplitude circadian rhythms in Drosophila driven by calcineurin-mediated post-translational control of sarah. Genetics 209, 815-828. **co-corresponding authors. [PubMed]

27. Kim, M.*, Jang, D.*, Yoo, E.*, Oh, Y., Sonn, J.Y., Lee, J., Ki, Y., Son, H.J., Hwang, O., Lee, C., Lim, C.**, and Choe, J.** (2017). Rogdi defines GABAergic control of a wake-promoting dopaminergic pathway to sustain sleep in Drosophila. Scientific Reports 7, 11368. *co-first authors; **co-corresponding authors. [PubMed][OPEN Access]

26. Lee, H., Jeong, H., Choe, J., Jun, Y., Lim, C., and Lee, C. (2017). The crystal structure of human Rogdi provides insight into the causes of Kohlschutter-Tönz Syndrome. Scientific Reports 7, 3972. [PubMed][OPEN Access]

25. Lee, J.*, Yoo, E.*, Lee, H.*, Park, K., Hur, J.-H., and Lim, C. (2017). LSM12 and ME31B/DDX6 define distinct modes of posttranscriptional regulation by ATAXIN-2 protein complex in Drosophila circadian pacemaker neurons. Molecular Cell 66, 129-140. *co-first authors. [PubMed][OPEN Access]

24. Kim, M., Lee, H., Hur, J-H., Choe, J.**, and Lim, C.** (2016). CRTC potentiates light-independent timeless transcription to sustain circadian rhythms in Drosophila. Scientific Reports 6, 32113. **co-corresponding authors. [PubMed][OPEN Access]

23. Ki, Y., Ri, H., Lee, H., Yoo, E., Choe, J., and Lim, C. (2015). Warming up your tick-tock: temperature-dependent regulation of circadian clocks. Neuroscientist 21, 503-518. [PubMed]

22. Park, S., Sonn, J.Y., Oh, Y., Lim, C., and Choe, J. (2014). SIFamide and SIFamide receptor defines a novel neuropeptide signaling to promote sleep in Drosophila. Molecules and Cells 37, 295-301. [PubMed][OPEN Access]

21. Lim, C.** and Allada, R.** (2013). Emerging roles for post-transcriptional regulation in circadian clocks. Nature Neuroscience 16, 1544-1550. **co-corresponding authors. [PubMed]

20. Lim, C and Allada, R. (2013). ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila. Science 340, 875-879. [PubMed]

19. Lim, C.*, Lee, J.*, Choi, C., Kilman, V.L., Kim, J., Park, S.M., Jang, S.K., Allada, R.**, and Choe, J.** (2011). The novel gene twenty-four defines a critical translational step in the Drosophila clock. Nature 470, 399-403. *co-first authors; **co-corresponding authors. [PubMed] 

18. Cha, S.*, Lim, C.*, Lee, J.Y., Song, Y.J., Park, J., Choe, J., and Seo, T. (2010). DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication. Biochem Biophys Res Commun 394, 934-939. *co-first authors. [PubMed]

17. Choi, C., Lee, J., Lim, C., Jang, D., and Choe, J. (2009). The DOUBLETIME protein kinase regulates phosphorylation of the Drosophila PDP1epsilon. J Neurochem 111, 264-273. [PubMed]

16. Lim, C.*, Lee, J.*, Koo, E., and Choe, J. (2007). Targeted inhibition of Pdp1epsilon abolishes the circadian behavior of Drosophila melanogaster. Biochem Biophys Res Commun 364, 294-300. *co-first authors. [PubMed]

15. Lim, C.*, Chung, B.Y.*, Pitman, J.L., McGill, J.J., Pradhan, S., Lee, J., Keegan, K.P., Choe, J.**, and Allada, R.** (2007). Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol 17, 1082-1089. *co-first authors; **co-corresponding authors. [PubMed]

14. Lim, C., Lee, J., Choi, C., Kim, J., Doh, E., and Choe, J. (2007). Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol 27, 4876-4890. [PubMed]

13. Seo, T., Park, J., Lim, C., and Choe, J. (2004). Inhibition of nuclear factor kappaB activity by viral interferon regulatory factor 3 of Kaposi's sarcoma-associated herpesvirus. Oncogene 23, 6146-6155. [PubMed]

12. Lim, C., Seo, T., Jung, J., and Choe, J. (2004). Identification of a virus trans-acting regulatory element on the latent DNA replication of Kaposi's sarcoma-associated herpesvirus. J Gen Virol 85, 843-855. [PubMed]

11. Lim, C., Choi, C., and Choe, J. (2004). Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus. J Virol 78, 7248-7256. [PubMed]

10. Lim, C., Lee, D., Seo, T., Choi, C., and Choe, J. (2003). Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1. J Biol Chem 278, 7397-7405. [PubMed]

9. Kim, S., Ko, J., Shin, H., Lee, J.R., Lim, C., Han, J.H., Altrock, W.D., Garner, C.C., Gundelfinger, E.D., Premont, R.T., Kaang, B.K. and Kim, E. (2003). The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Biol Chem 278, 6291-6300. [PubMed]

8. Lee, D., Lim, C., Seo, T., Kwon, H., Min, H., and Choe, J. (2002). The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions. J Biol Chem 277, 48842-48848. [PubMed]

7. Lim, C., Sohn, H., Lee, D., Gwack, Y., and Choe, J. (2002). Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol 76, 10320-10331. [PubMed]

6. Gwack, Y., Hwang, S., Lim, C., Won, Y.S., Lee, C.H., and Choe, J. (2002). Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3. J Biol Chem 277, 6438-6442. [PubMed]

5. Hwang, S., Gwack, Y., Byun, H., Lim, C., and Choe, J. (2001). The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J Virol 75, 9509-9516. [PubMed]

4. Lim, C., Gwack, Y., Hwang, S., Kim, S., and Choe, J. (2001). The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem 276, 31016-31022. [PubMed]

3. Gwack, Y., Hwang, S., Byun, H., Lim, C., Kim, J.W., Choi, E.J., and Choe, J. (2001). Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol 75, 6245-6248. [PubMed]

2. Gwack, Y., Byun, H., Hwang, S., Lim, C., and Choe, J. (2001). CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol 75, 1909-1917. [PubMed]

1. Lim, C., Sohn, H., Gwack, Y., and Choe, J. (2000). Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol 81, 2645-2652. [PubMed]