Publications
Manuscripts in progress
Healy CP, Adler FR, Deans T.L. (submitted). Rolling Signal-based Ripley’s K: A new algorithm to identify spatial patterns in histological specimens. DOI: https://dx.doi.org/10.2139/ssrn.3606781
Published Manuscripts
2021
Javdan, S.B., and Deans, T.L. (2021). Design and development of engineered receptors for cell and tissue engineering. Curr Opin Syst. DOI: https://doi.org/10.1016/j.coisb.2021.100363
MacDonald, I.C., Seamons, T.R., Emmons, J.C., Javdan, S.B., and Deans, T.L. (2021). Enhanced regulation of prokaryotic gene expression by a eukaryotic transcriptional activator. Nature communications 12, 4109. DOI: https://doi.org/10.1038/s41467-021-24434-9
Bowdish, D., Desai, T.A., DePace, A., Haswell, E.S., Baltrus, D., Garcia, A.J., Deans, T., Lage, K., and Wittkopp, P. (2021). Leadership. Cell Syst 12, 1-4. DOI: https://doi.org/10.1016/j.cels.2020.12.004 or PDF
Bush, L.M., Healy, C.P., Marvin, J.E., and Deans, T.L. (2021). High-throughput enrichment and isolation of megakaryocyte progenitor cells from the mouse bone marrow. Sci Rep 11, 8268. DOI: https://doi.org/10.1038/s41598-021-87681-2.
Davis, B., Backus, K., Winter, G., Chica, R., Li, D., Lee, S.Y., He, C., Week., A., Overall, C., Hagihara., S., Thuronyi, B., Kamat, S., Chen, L., Guerrero, R.H., Yao, S., Mahal, L.K., Voigt, C., Woo, C., Strauss, E., Kikuchi, K., Dore, T., Radform, S., Li, X.D., Heo, W.D., Superti-Furga., G., Deans., T.L., Belousov., V., Matthews, M., Jackson, C., Malek, S., Waldmann, H., Rising, A., Jewett, M., Stamou, D., Parker, E., Murakami, M., Polizzi, K., Hamachi, I., Erb, T., Joo, C., Uesugi, M., Prinja, R., Rechavi, G., Solano, R., Schulman, B., David, Y., Oslund, R. (2021). Voices of chemical biology. Nature chemical biology 17, 1-4. DOI: https://doi.org/10.1038/s41589-020-00714-1 or PDF
Persson, K.M., Kneller, P.V., Livingston, M.W., Bush, L.M., and Deans, T.L. (2021). High-Throughput Production of Platelet-Like Particles. Methods in molecular biology 2258, 273-283. DOI: https://doi.org/10.1007/978-1-0716-1174-6_18 or PDF
2020
Bush, L.M., Healy, C.P., Javdan, S.B., Emmons, J.C., and Deans, T.L. (2020). Biological Cells as Therapeutic Delivery Vehicles. Trends Pharmacol Sci.(cover) DOI: https://doi.org/10.1016/j.tips.2020.11.008 or PDF
Fitzgerald, M., Livingston, M., Gibbs, C., and Deans, T.L. (2020). Rosa26 docking sites for investigating genetic circuit silencing in stem cells. Synth Biol (Oxf) 5, ysaa014. DOI: https://doi.org/10.1093/synbio/ysaa014 or PDF
Yao, S., Aye, Y., Sun, J., Polizzi, K., Paulson, J.C., Kamat, S., Li, D., Chica, R., Weeks, A., Thuronyi, B., Brodin, P., Davis, B., Erb, T., Lei, X., Deans, T. L., Li, X.D., Backus, K., Lee, S.Y., Chen, L., Strauss, E., Malek, S., O’Connor, S.E., Jenner, M., Jewett, M., Parker, E., Hamachi, I., Mahal, L.K., Rechavi, G., Rising, A., Rodriguez, R., Prinjha, R., Murakami, M. (2020). Voices of chemical biology. Nature chemical biology 16, 598-599. DOI: https://doi.org/10.1038/s41589-020-0543-8 or PDF
2019
Vogel, A.M., Persson, K.M., Seamons, T.R., and Deans, T.L. (2019). Synthetic biology for improving cell fate decisions and tissue engineering outcomes. Emerging Topics in Life Sciences. DOI: doi.org/10.1042/ETLS20190091 or PDF
Bush, L.M., Gibbs, C., and Deans, T.L. (2019). Synthetic biology: paving the way with novel drug delivery. The Biochemist 41, 24. DOI:doi.org/10.1042/BIO04103024 or PDF
Healy, C.P., and Deans, T.L. (2019). Genetic circuits to engineer tissues with alternative functions. J Biol Eng 13, 39. DOI: 10.1186/s13036-019-0170-7 or PDF
2018
Weisenberger, M. and Deans, T.L. (2018). "Bottom-up approaches in synthetic biology and biomaterials for tissue engineering applications" Journal of Industrial Microbiology & Biotechnology DOI:10.1007/s10295-018-2027-3 or PDF.
2017
Fitzgerald, M., Gibbs, C, Shimpi, A.A., and Deans, T.L. “Adoption of the Q Transcriptional System for Regulating Gene Expression in Stem Cells”, ACS Synthetic Biology (2017). DOI: 10.1021/acssynbio.7b00149 or PDF
2016
Deans, T.L., Grainger, D.W., and Fussenegger, M. (2016) “Synthetic Biology: Innovative approaches for pharmaceutics and drug delivery”, Advanced Drug Delivery Review (ADDR) 105(1): 1-2. DOI: 10.1016/j.addr.2016.08.013 or PDF
MacDonald, C., Deans, T.L. (2016). “Tools and Applications in Synthetic Biology”. Advanced Drug Delivery Review (ADDR) 105(1): 20-34. DOI: 10.1016/j.addr.2016.08.008 or PDF
2015
Lam, A., Deans, T.L. (2015). “A Noisy Tug of War: The Battle Between Transcript Production and Degradation in the Liver”. Developmental Cell 33(1): 3-4. DOI: 10.1016/j.devcel.2015.03.019 or PDF
2014 and earlier
Deans, T.L., (2014). “Parallel Networks: Synthetic Biology and Artificial Intelligence.” ACM Journal on Emerging Technologies in Computing Systems (JETC). 11(3), 21. DOI: 10.1145/2667229 or PDF
Singh*, A., Deans, T.L.*, Elisseeff, J.H. (2013). “Photomodulation of cellular gene expression in hydrogels.” ACS Macro Lett. 2(1): 269-272. DOI: 10.1021/mz300591m or PDF
*Authors contributed equally to this work
Deans, T.L.*, Singh*, A., Gibson, M., and Elisseeff, J.H. (2012). “Regulating Synthetic Gene Networks in 3D Materials ”Proc Natl Acad Sci USA 109(38): 15217-22. DOI: 10.1073/pnas.1204705109 or PDF
*Authors contributed equally to this work
Deans, T.L., Elisseeff, J. (2010). “The life of a cell: Probing the complex relationships with the world” Cell Stem Cell 6(6): 499-501. DOI: 10.1016/j.stem.2010.05.009 or PDF
Deans, T.L., Elisseeff, J. (2009). “Stem cells in musculoskeletal engineered tissue”, Curr Opin Biotechnol 20(5): 537-44. DOI: 10.1016/j.copbio.2009.10.005 or PDF
Deans, T.L., Elisseeff, J. (2009). “Mimicking Extracellular Matrix to Direct Stem Cell Differentiation”, World Stem Cell Report. PDF
Deans, T.L, Cantor, C.R. and Collins, J.J. (2007). A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells, Cell 130(2): 363-72. DOI: 10.1016/j.cell.2007.05.045 or PDF