Research

Protein Sequencing By Motion response

Proteins! Identify yourself!

When we meet someone, we recognize them mostly by their appearance. When it comes to a protein, unfortunately, we cannot really "see" it because a single protein is too small for our eyes or any of the scientific instruments available today. So, do we give up? NOPE! We have an idea: if we know how a protein behaves, we might be able to identify it. In the lab, we trap a protein on a well-defined 2D surface and let it play. By observing how fast or strangely it moves around, we can determine what kind of protein it is. If necessary, we rock it by various means to uncover its habits—additional information for identification. Curious about the details? Contact us; we have more stories to share! 

By BNEM & iBPL

protein sequencing by structural profiling

We've got your finger print!

We want to determine the sequence of a protein. Wait, a protein sequence? Not DNA? Yes, we said protein because knowing exactly what kinds of proteins are present in a cell or tissue at a specific time is extremely valuable—not only for researchers in fundamental science but also for medical doctors who want to assess their patients' health. So, how do we sequence a protein? We use a cutting-edge nano-optics technique to analyze the structure of a single protein molecule. Of course, we cannot literally "see" a protein. Instead, we measure a small set of key structural information at the single-molecule level using iMaxFRET, a unique nano-optics method. We have strong reasons to believe that such partial structural information is sufficient to determine a protein's sequence. Want to know more? Come and chat with us—we’d love to share the details!

By Joo lab and iBPL

Prokaryotic Argonaute - what are they for?

To regulate or to defend?
That is the question!

Have you heard of Argonaute proteins? These fascinating molecules play crucial roles in maintaining genetic integrity, with their functions varying across the biological world. In eukaryotes, many Argonaute proteins are key players in RNA silencing, where they use small RNA guides to regulate gene expression.

But what about prokaryotic Argonautes? These lesser-known proteins offer unique possibilities. Unlike their eukaryotic counterparts, prokaryotic Argonautes can use either RNA or DNA guides, unlocking exciting applications. Imagine using this natural system to develop safer genome-editing tools, combat antibiotic resistance, or design innovative technologies.

In our lab, we're diving deep into the uncharted world of Argonautes, exploring their unique mechanisms and boundless potential. Curious about the incredible possibilities these proteins hold? Join us on this exciting journey and be part of the discovery!

By Joo lab and iBPL

nano QR code

The world smallest QR code!!!

QR code? Barcode? Well, it is basically a tag, meaning that a barcode is used to distinguish objects by a computer system. QR code is a 2D version of the barcode and carries more information. Barcode and QR code are everywhere in our daily life. So, we thought, why not use this tech in our daily experiments? Think about it. If you put tags on different molecules you want to study, you don't have to measure them one by one any more. You can measure them all at once and sort them out later based on their tags. How convenient! This is a fine example of 'Smart laziness'. Are you smart enough to do this with us? Or should we say 'Lazy' enough? 

By iBPL