Journal club
12Feb24
Massively parallel measurement of protein–protein interactions by sequencing using MP3-seq
https://doi.org/10.1038/s41589-024-01718-x
De novo designed proteins neutralize lethal snake venom toxins
https://doi.org/10.1038/s41586-024-08393-x
Single-Molecule Investigation of the Protein–Aptamer Interactions and Sensing Application Inside the Single Glass Nanopore
https://doi.org/10.1021/acs.analchem.2c02660
15Jan25
Supervised multi-frame dual-channel denoising enables long-term single-molecule FRET under extremely low photon budget
https://doi.org/10.1038/s41467-024-54652-w
06Jan25
Tracking transcription–translation coupling in real time
https://doi.org/10.1038/s41586-024-08308-w
18Dec24
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH
https://doi.org/10.1038/s41586-019-1049-y
10Dec24
Spatially resolved, highly multiplexed RNA profiling in single cells
https://doi.org/10.1126/science.aaa6090
04Dec24
Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells
https://doi.org/10.1038/nmeth.3475
27Nov24
Single-molecule fluorescence multiplexing by muti-parameter spectroscopic detection of nanostructured FRET labels
https://doi.org/10.1038/s41565-024-01672-8
20Nov24
ABEL-FRET: tether-free single-molecule FRET with hydrodynamic profiling
https://doi.org/10.1038/s41592-021-01173-9
13Nov24
Spatially resolved, highly multiplexed RNA profiling in single cells
06Nov24
Quantifying T cell receptor mechanics at membrane junctions using DNA origami tension sensors
https://doi.org/10.1038/s41565-024-01723-0
30Oct24
RNA-guided RNA silencing by an Asgard archaeal Argonaute
https://doi.org/10.1038/s41467-024-49452-1
23Oct24
Mechanical force regulates ligand binding and function of PD-1
https://doi.org/10.1038/s41467-024-52565-2
16Oct24
Multi-pass, single-molecule nanopore reading of long protein strands.
https://doi.org/10.1038/s41586-024-07935-7
02Oct24
A single-vesicle content mixing assay for SNARE-mediated membrane fusion.
https://doi.org/10.1038/ncomms1054
25Sep24
Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes.
https://doi.org/10.1038/nbt.2880
13Sep24
Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics
https://doi.org/10.1016/j.molcel.2022.04.024
04Sep24
A single-vesicle content mixing assay for SNARE-mediated membrane fusion
https://doi.org/10.1038/ncomms1054
28Aug24
Distance Dependence of Single-Fluorophore Quenching by Gold Nanoparticles Studied on DNA Origami
https://doi.org/10.1021/nn2050483
21Aug24
TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity.
14Aug24
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning.
https://doi.org/10.1038/nbt.3300
07Aug24
Single-molecule FRET imaging of GPCR dimers in living cells.
https://doi.org/10.1038/s41592-021-01081-y
31JUL24
DropBlot: single-cell western blotting of chemically fixed cancer cells.
17JUL24
Torsional Stiffness of Extended and Plectonemic DNA
10JUL24
Biological Nanopore Approach for Single-Molecule Protein Sequencing
https://doi.org/10.1002/ange.202013462
03JUL24
Single-Molecule Peptide Identification Using Fluorescence Blinking Fingerprints
https://doi.org/10.1021/jacs.2c12561
26JUN24
A DNA origami-based device for investigating DNA bending proteins by transmission electron microscopy
https://doi.org/10.1039/D2NR05366G
19JUN24
A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors
https://doi.org/10.1126/science.1131007
12JUN24
Affinity microfluidics enables high-throughput protein degradation analysis in cell-free extracts
https://doi.org/10.1038/s42003-022-04103-3
17APR24
Mapping Single-Molecule Protein Complexes in 3D with DNA Nanoswitch Calipers
https://pubs.acs.org/doi/10.1021/jacs.3c10262
11APR24
Supported Bilayer Electrophoresis under Controlled Buffer Conditions
https://doi.org/10.1021/ac1028819
03APR24
An electroactive microwell array device to realize simultaneous trapping of single cancer cells and clusters
https://doi.org/10.1039/D2LC00171C
28MAR24
An electroactive microwell array device to realize simultaneous trapping of single cancer cells and clusters
https://doi.org/10.1039/D2LC00171C
20MAR24
ProtSeq: Toward high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes
https://doi.org/10.1016/j.isci.2021.103586
13MAR24
Protein Separation by Electrophoretic–Electroosmotic Focusing on Supported Lipid Bilayers
https://pubs.acs.org/doi/10.1021/ac201768k
06MAR24
Enzyme-less nanopore detection of post-translational modifications within long polypeptides
https://doi.org/10.1038/s41565-023-01462-8
27FEB24
Single molecule electrometry
https://doi.org/10.1038/nnano.2017.26
22FEB24
Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device
https://doi.org/10.1126/science.abo7651
07FEB24
Single molecule digital sizing:
https://doi.org/10.1101/2023.07.12.548675
24JAN24
Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity:
https://doi.org/10.1101/2023.10.19.563182
03JAN24
Real-Time Structural Biology of DNA and DNA-Protein Complexes on an Optical Microscope
https://doi.org/10.1101/2023.11.21.567962
27DEC23
Single Protein molecules separation, tracking and counting in ultra-thin silicon channels
https://doi.org/10.1101/2023.11.09.566381
20DEC23
Optical imaging of single-protein size, charge, mobility, and binding
https://doi.org/10.1038/s41467-020-18547-w