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Recent Research
Please find a full list of our publications at https://scholar.google.com/citations?user=h3Dug4IAAAAJ&hl=en
Collagen binding adhesin restricts Staphylococcus aureus infection
Collagen binding adhesin restricts Staphylococcus aureus infection
Bhattacharya M, Brady Spencer, Jakub Kwiecinski, Magdalena Podkowik, Gregory Putzel, Alejandro Pironti, Bo Shopsin, Kelly S. Doran, Alexander R. Horswill. Nat Commun 17, 1980 (2026). https://doi.org/10.1038/s41467-026-68788-4
Absence of sortase-anchored collagen binding adhesin (Cna(-)) results in visibly worsened skin abscess infection
Cna binds to C1q stem, sequestering it and preventing optimal activity
Leads to increased uptake by neutrophils, significanlty higher neutrophil death (hPMN/microscopy) and absence of live macrophages with higher levels of matrix metalloproteases (flow cytometry).
The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections
The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections
Bhattacharya M, Alexander R. Horswill. FEMS Microbiology 2024, doi: 10.1093/femsre/fuae002
Overview of the major host extracellular matrix components in the human body and how they interact with biofilm communities established by Staphylococcus aureus.
Key examples of commonly recalcitrant S. aureus infection are provided, with a specific discussion on the host matrix partners involved
Avenues and challenges in the development of therapeutics that can target these interactions are discussed
Extracellular adherence proteins reduce matrix porosity and enhance Staphylococcus aureus biofilm survival during prosthetic joint infection
Bhattacharya M, Tyler Scherr, Jessica Lister, Tammy L. Kielian, Alexander R. Horswill. Infect Immun. 2025 Apr 93;4:e00086-25. doi: 10.1128/iai.00086-25. PMID: 39677627 PMCID: PMC11643045
Describes the role of a group of secreted and surface attached proteins in the extracellular polymeric substance of biofilms
Extracellular adherence proteins reduce entry of forgein particles into the biofilm
Eap proteins hamper macrophage influx and phagocytosis
Select past publications
Biofilms and the neutrophil response to S. aureus
Biofilms and the neutrophil response to S. aureus
Bhattacharya M, Evelien T.M. Berends, Xuhui Zheng, Preston J Hill, Rita Chan, Victor J. Torres, Daniel J. Wozniak. Leukocidins and the Nuclease Nuc Prevent Neutrophil-Mediated Killing of Staphylococcus aureus Biofilms. Infect Immun. 2020 Sep 18;88(10):e00372-20. doi: 10.1128/IAI.00372-20. PMID: 32719153; PMCID: PMC7504955.
Bhattacharya M, Evelien T. M. Berends, Rita Chan, Elizabeth Schwab, Sashwati Roy, Chandan K Sen, Victor J. Torres, Daniel J. Wozniak. Staphylococcus aureus biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7416-7421. doi: 10.1073/pnas.1721949115. Epub 2018 Jun 25. PMID: 29941565; PMCID: PMC6048508.
Bhattacharya M. The NET response to biofilm infections. Viral, Parasitic, Bacterial and Fungal Infections. Antimicrobial, Host Defense, and Therapeutic Strategies 2023, Pages 575-589
Bhattacharya M, Daniel J. Wozniak, Paul Stoodley, Luanne Hall-Stoodley. Prevention and treatment of Staphylococcus aureus biofilms. Expert Rev Anti Infect Ther. 2015;13(12):1499-516. doi: 10.1586/14787210.2015.1100533. Epub 2015 Nov13. PMID: 26646248; PMCID: PMC51428221.
Polymicrobial infections
Polymicrobial infections
Klara Keim, Mohini Bhattacharya, Heidi A. Crosby, Christian Jenul, Michael Schurr, and Alexander Horswill. Polymicrobial interactions between Staphylococcus aureus and Pseudomonas aeruginosa promote biofilm formation and persistence in chronic wound infections. https://www.biorxiv.org/content/10.1101/2024.11.04.621402v1
Immunity to S. aureus
Immunity to S. aureus
Bernardino PN, Mohini Bhattacharya, Xinhai Chen, Julia Jenkins J, Dominique Missiakas, Vilasack Thammavongsa. A humanized monoclonal antibody targeting protein a promotes opsonophagocytosis of Staphylococcus aureus in human umbilical cord blood. Vaccine. 2023 Aug 7;41(35):5079-5084. doi: 10.1016/j.vaccine.2023.07.018. Epub 2023 Jul 16. PMID: 37455161; PMCID: PMC10412981.
Collaborations
Collaborations
Sindhura John M, Mahendran Chinnappan, Methinee Artami, Mohini Bhattacharya, Rebecca Keogh, Jeffrey Kavanaugh, Alexander R. Horswill, Tamia A. Harris-Tryon. Androgens excreted at the skin surface regulate S. aureus pathogenesis through activation of agr quorum sensing. Nat Microbiol 11, 704–717 (2026). https://doi.org/10.1038/s41564-026-02261-2
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