Collagen constitutes approximately 30% of the total protein dry weight in the human body. It plays a central role in host cell adhesion and regulation of immune cell function through various mechanisms. In order to establish an infection, all microbes therefore likely interact with collagen in some capacity. This can significantly influence how pathogens evade host immune defenses. With a specific focus on skin infections caused by methicillin resistant Staphylococcus aureus (MRSA), the Bhattacharya lab will dissect the molecular mechanisms by which collagen interactions modulate infection dynamics, focusing on how specific bacterial adhesins and host derived molecules orchestrate immune responses and influence bacterial persistence at the site of infection.

 We have described significant roles for additional host extracellular matrix components that act as collagen bridges to contribute to collagen accumulation around the infection nidus. Our goals extend to understanding the role of these molecular interactions in bacterial community development and immune evasion. We will also determine the dynamics of collagen competition in chronic-biofilm associated and polymicrobial infections commonly established with Pseudomonas aeruginosa and Enterococcus faecalis.