Research

Pathways to Innate Immune Tolerance and Neuroprotection

We investigate molecular “brake” rather than a passive loss of responsiveness. A major focus is targeting mitochondrial innate immune signaling for neuroprotection in MS.  

The Gharagozloo Lab is actively studying NLRX1, a Mitochondrial Innate Immune Sensor.In addition, the lab explores novel pathways that reprogram inflammatory signaling in innate immune cells to promote immune tolerance and therapeutic resilience. 

• Inhibition of TLR and NF‑κB Signaling Pathways: We study inhibitory NOD-like Receptors (NLRs) and their role in the onset and pogression of CNS autoimmunity. 

• Manipulation of Immunometabolic Checkpoints: NLRX1 is an immunoregulatory molecule and a candidate modulator of the interplay between neuroinflammation, metabolism, and neurodegeneration in MS. 

• MicroRNA Modulation: We target specific microRNAs to enhance inhibitory NLR function, reduce pathological inflammatory signaling, and promote neuroprotection.

• RNA-Based Therapeutics: We develop targeted RNA delivery strategies to precisely modulate innate immune signaling, enhance immune tolerance, and therapeutically manipulate innate immune receptors.