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The Gharagozloo Lab
Johns Hopkins
School of Medicine
600 N. Wolfe Street
Meyer 6-130, 138
Baltimore, MD 21287 map
My research focuses on understanding the immunological mechanisms underlying chronic neuroinflammation and neurodegeneration in multiple sclerosis (MS). In my lab, we utilize various MS experimental models to expedite the discovery of innovative therapeutic approaches to stop neurodegeneration and promote remyelination. My career has been marked by diverse collaborations across neuroimmunology and immunopharmacology, profoundly influencing my perspective on innovative therapeutic avenues for MS.
My research focuses on understanding the immunological mechanisms underlying chronic neuroinflammation and neurodegeneration in multiple sclerosis (MS). In my lab, we utilize various MS experimental models to expedite the discovery of innovative therapeutic approaches to stop neurodegeneration and promote remyelination. My career has been marked by diverse collaborations across neuroimmunology and immunopharmacology, profoundly influencing my perspective on innovative therapeutic avenues for MS.
Gill, A. J., Smith, M. D., Galleguillos, D., Garton, T., Mace, J. W., Gadani, S. P., ... & Gharagozloo, M. (2025). NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway. Journal of Neuroinflammation, 22(1), 1-22.
Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D. NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity. PLoS Biol. 2019;17(9):e3000451.
Gharagozloo M, Smith MD, Jin J, Garton T, Taylor M, Chao A, Meyers K, Kornberg MD, Zack DJ, Ohayon J, Calabresi BA, Reich DS, Eberhart CG, Pardo CA, Kemper C, Whartenby KA, Calabresi PA. Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation. Acta Neuropathol. 2021;142(5):899-915.
Absinta M, Maric D, Gharagozloo M, Garton T, Smith MD, Jin J, Fitzgerald KC, Song A, Liu P, Lin JP, Wu T, Johnson KR, McGavern DB, Schafer DP, Calabresi PA, Reich DS. A lymphocyte-microglia- astrocyte axis in chronic active multiple sclerosis. Nature. 2021;597(7878):709-714.
Gharagozloo M, Galleguillos D, Jank L, Sotirchos ES, Smith MD, Garton T, Kumar S, Hussein O, Potluri S, Taylor M, Siu C, Mace JW, Dawson T, Dawson VL, Lee S, Calabresi PA. The effect of NLY01, a Novel Glucagon-like Peptide-1 Receptor Agonist, in Cuprizone-Induced Demyelination and Remyelination Models. Neurotherapeutics, 2023, Jul;20(4):1229-1240.
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