これまでの研究業績
これまでの研究業績
Tada H, Shinohara M, Teramoto A, Satake S, Krell-Roesch J, Matsumoto S, Yamada M, Satoh T, Kawano R, Suzuki K, Kondo I, Akishita M, Arai H, Geda YE, Watada H, Sato N. "MyEveryCise: A method for everyday exercise using “an activity of daily living” as a cue." J Alzheimers Dis, In press.
Tsushima M, Tada H, Asai A, Hirose M, Hosoyama T, Watanabe A, Murakami T, Sugimoto M. "Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice. " Aging, 16(13):10670-10693, 2024.
Furukawa M, Tada H, Raju R, Wang J, Yokoi H, Yamada M, Saito T, Saido TC, Shikama Y, Matsushita K. "Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice." Journal of Oral Biosciences, 66(2):329-338, 2024.
Furukawa M, Yokoi H, Wang J, Ikuyo Y, Tada H, Yamada M, Shikama Y, Matsushita K. "Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice." Genes to Cells, 29(5):417-422,2024.
Urushihata T, Goto M, Kabetani K, Kiyozuka M, Maruyama S, Tsuji S, Tada H, Satoh A. "Evaluation of cellularneuronal activity in response to sleep deprivation by a comprehensive analysis of the whole mouse brain." Front. Neurosci., 17, 2023.
Furukawa M, Tada H, Raju R, Wang J, Yokoi H, Ikuyo Y, Yamada M, Shikama Y, Matsushita K. "Long-Term Capsaicin Administration Ameliorates the Dysfunction and Astrogliosis of the Brain in Aged Mice with Missing Maxillary Molars." Nutrients, 15(11):2471, 2023.
Furukawa M, Tada H, Raju R, Wang J, Yokoi H, Yamada M, Shikama Y, Matsushita K. "Long-Term Soft-Food Rearing in Young Mice Alters Brain Function and Mood-Related Behavior." Nutrients, 15(10):2397, 2023.
Tsuji S, Brace CS, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai S, Satoh A. "Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice." Life Science Alliance, 6(6):e202301992, 2023.
Furukawa M, Tada H, Wang J, Yamada M, Kurosawa M, Satoh A, Ogiso N, Shikama Y, Matsushita K. "Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice." Sci Rep, 12(1):6409, 2022.
Abe H, Jitsuki S, Nakajima W, Murata Y, Jitsuki-Takahashi A, Katsuno Y, Tada H, Sano A, Suyama K, Mochizuki N, Komori T, Masuyama H, Okuda T, Goshima Y, Higo N, Takahashi T. "CRMP2 binding compound, edonerpic maleate, accelerates motor function recovery from brain damage." Science, 360(6384):50-57, 2018.
Tada H, Miyazaki T, Takemoto K, Jitsuki S, Nakajima W, Koide M, Yamamoto N, Taguchi A, Kawai H, Komiya K, Suyama K, Abe H, Sano A, Takahashi T."Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex." Sci Rep, 7(1):8471, 2017.
Takemoto K, Iwanari H, Tada H, Suyama K, Sano A, Nagai T, Hamakubo T, Takahashi T."Optical inactivation of synaptic AMPA receptors for artificial memory erasure."Nat Biotechnol , 35(1):38-47, 2017.
Tada H, Miyazaki T, Takemoto K, Takase K, Jitsuki S, Nakajima W, Koide M, Yamamoto N, Komiya K, Suyama K, Sano A, Taguchi A, Takahashi T. "Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex." PNAS, 113(45):E7097-E7105, 2016.
Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W, Okano H."Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines."Mol Brain, 9(1):88, 2016.
Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H."Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling."Stem Cell Reports, 6(3):422-435, 2016.
Jitsuki S, Nakajima W, Takemoto K, Tada H, Takahashi-Jitsuki A, Sano A, Takahashi T."Nogo receptor signaling restricts adult neural plasticity by limiting synaptic AMPA receptor delivery."Cereb Cortex, 26(1):427-439, 2016.
Tada H, Koide M, Ara W, Shibata S, Funabashi T, Suyama K, Goto T, Takahashi T."Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats."PloS One , 10(6):e0131359, 2015.
Tada H, Kuroki Y, Funabashi T, Kamiya Y, Goto T, Suyama K, Sano A, Mitsushima D, Etgen AM, Takahashi T. "Phasic synaptic incorporation of GluR2-lacking AMPA receptors at gonadotropin-releasing hormone neurons is involved in the generation of the luteinizing hormone surge in female rats."Neuroscience, 248:664-669, 2013.
Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T. "Disrupted cortical function underlies behavior dysfunction due to social isolation."J Clin Invest, 122(7):2690-2701, 2012.
Miyazaki T, Kunii M, Tada H, Sano A, Kuroiwa Y, Goto T, Malinow R, Takahashi T. "Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel cortex."Brain Res, 1435:1-7, 2012.
Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Yasuda A, Nori S, Mabuchi Y, Tada H, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, Okano H. "Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition."EMBO Mol Med, 3(11):682-696, 2011.
Jitsuki S, Takemoto K, Kawasaki T, Tada H, Takahashi A, Becamel C, Sano A, Yuzaki M, Zukin RS, Ziff EB, Kessels HW, and Takahashi T. "Serotonin mediates cross-modal reorganization of cortical circuits."Neuron, 69(4):780-792, 2011.
Sakaguchi M, Imaizumi Y, Shingo T, Tada H, Hayama K, Yamada O, Morishita T, Kadoya T, Uchiyama N, Shimazaki T, Kuno A, Poirier F, Hirabayashi J, Sawamoto K, Okano H. "Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction."J Neurochem, 113(6):1516-1524, 2010.
Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H. "Fbxo45, a novel ubiquitin ligase, regulates synaptic activity." J Biol Chem, 285(6):3840-3849, 2010.
Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HJ, Okano H, Nakayama KI. "Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development." Mol Cell Biol , 29(13):3529-3543, 2009.
Tada H, Ishii S, Kimura H, Hattori H, Okada Y, Suzuki N, Okano HJ. "Identification and Evaluation of High-titer Anti-Sox Group B Antibody in Limbic Encephalitis."Inflamm Regen, 27(1):37-44, 2007.
元井章智，山中大輔，赤木一考，多田敬典「露地栽培アガリクスKA21株の抗加齢分野に関する最新知見」若返り (rejuvenation) の医学，Medical Science Digest, 51(6):34-37, 2025.
笹竹英穂, 杉島有希, 伊良皆望美, 村上太郎, 桑原裕子, 多田敬典, 谷岡郁子「心理学でアプローチ がまんさせないスポーツ栄養指導法」（大修館書店）, 2025.
多田敬典「内分泌系の加齢変化と脳認知機能」特集/SASPから紐解く老化と老化関連疾患，老年内科，2(6) 672–679, 2020.
多田敬典「社会的認知機能における攻撃性制御の意義と分子機序の解明」，日本生理学会雑誌, AWARDS, 81(2):25, 2019.
多田敬典，徳永暁憲，田之頭大輔，倉田栄子，田口明子「糖代謝シグナルを介した認知機能制御機構」，基礎老年研究誌，40(2):9-14, 2016.
多田敬典，高橋琢哉「ストレスと認知記憶」，生体の科学，67(1):47-50, 2016.
多田敬典「辺縁系脳炎患者血清中に存在する高力価抗Sox Group B抗体の同定と評価」，慶應医学，84(2):18, 2007.
多田敬典，岡野栄之「神経幹細胞と神経再生」，新世紀の精神科治療（中山書店），第6巻（認知の科学と臨床）:219-229, 2003.
2021年3月 理事長奨励賞 国立長寿医療研究センターPCR検査SPOTチーム
2019年3月 第20回日本生理学会奨励賞 日本生理学会
2016年2月 優秀演題賞 第8回NAGOYAグローバルリトリート
発明の名称：寿命延長用食品組成物
発明者：多田 敬典, 赤木 一考, 徳永 暁憲, 安田 光佑, 中島 綾香, 鈴木 健吾
出願日：2021年11月22日
出願人：株式会社ユーグレナ, 国立研究開発法人国立長寿医療研究センター
特許番号： 特許第7258990号
発明者：多田 敬典, 元井 章智
出願日：2022年10月31日
出願人：東栄新薬株式会社, 学校法人至学館
特許出願号： 特願2022-174395
発明の名称：脱毛やEDなどの男性更年期障害の改善組成物、および、これを含む医薬・飲食品
発明者：多田 敬典, 元井 章智
出願日：2024年7月8日
出願人：東栄新薬株式会社, 学校法人至学館
特許出願号： 特願2024-109541
発明の名称：卵巣機能改善組成物およびこれを含む医薬、飲食品および飼料
発明者：赤木 一考, 多田 敬典, 元井 章智
出願日：2024年8月29日
出願人：東栄新薬株式会社、学校法人至学館、国立大学法人富山大学
特許出願号： 特願2024-147585