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Capturing the actions of key molecular complexes during Host-Pathogen Interactions
Capturing the actions of key molecular complexes during Host-Pathogen Interactions
Mission
Mission
Our mission is to elucidate the molecular mechanisms of host–pathogen interactions using interdisciplinary approaches, bridging fundamental biology and next-generation antimicrobial development.
Our mission is to elucidate the molecular mechanisms of host–pathogen interactions using interdisciplinary approaches, bridging fundamental biology and next-generation antimicrobial development.
Vision
Vision
Our vision is to apply cutting-edge cryo-EM approaches to visualize host-pathogen interactions in situ at high-resolution. By integrating cryo-EM with biochemistry, and pharmaceutical sciences, we aim to uncover new insights into the mechanisms of infection and to identify new targets for the development of new class of anti-infective therapies.
Our vision is to apply cutting-edge cryo-EM approaches to visualize host-pathogen interactions in situ at high-resolution. By integrating cryo-EM with biochemistry, and pharmaceutical sciences, we aim to uncover new insights into the mechanisms of infection and to identify new targets for the development of new class of anti-infective therapies.
Type III Secretion System - Injectisome
The type III secretion system (T3SS) is a needle-like apparatus found in many Gram-negative bacteria. This nanomachine injects virulence proteins directly into host cells, altering host cellular functions to promote bacterial pathogenesis.
We aim to visualize the contact sites between the Shigella injectisome and host cells to elucidate the structure and function of this nanomachine in situ.
Type IV Secretion System
The type IV secretion system (T4SS) is a nanomachine employed by many Gram-negative pathogens to translocate effector proteins into host cells. Notably, Helicobacter pylori possesses a T4SS that plays a critical role in the development of gastric cancer in humans.
Using cryo-electron tomography (cryo-ET), our laboratory investigates the in situ structure of the H. pylori T4SS to define its structure and to elucidate the mechanisms of protein translocation during infection.
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