The Structural Genome:

Merging Physics, Biology & Computation

October 11-13, 2023 - SISSA, Trieste (Italy)

The event

SISSA is organizing a scientific meeting on "The Structural Genome: Merging Physics, Biology & Computation" that will be hosted at the Scuola Internazionale Superiore di Studi Avanzati (SISSA) in Trieste, Italy on October 11-13, 2023, in collaboration with the local Node of the Centre Européen de Calcul Atomique et Moléculaire (CECAM).

What is it about?

The information expressed by a single DNA filament combines elements from the polynucleotide sequence with the three-dimensional folding of the sequence in the space of the cell. The latter, in particular, influences how genomes respond to external stimuli and attacks which may cause trouble to the healthy behavior of the cell.

The structure/function relationship of genomes is the focus of an intense multi-disciplinary effort, where experimental teams (super-resolution microscopy, chromosome conformation capture, in-vivo fluorescence imaging, ...) work side-by-side with theoretical ones (physical/mathematical models for the genomes, statistical analysis of gene expression profiles, bioinformatics analysis of DNA sequences, ...), with the mutual greatest benefit.

In this meeting, we will bring together an interdisciplinary audience including both experimentalists and experts of theory, computer simulations and data analysis. It will be an informal and interactive session favoring discussion and vision development for the future of this field and its interaction with different areas of biology.