Gkolfinopoulou C, Bourtsala A, Georgiadou D, Dedemadi AG, Stratikos E and Chroni E
J Lip Res 2024, accepted
95. Mechanisms of allosteric inhibition of Insulin- Regulated Aminopeptidase
Mpakali A, Barla I, Lu L, Ramesh KM, Thomaidis N, Stern LJ, Giastas P, and Stratikos E*
J Mol Biol 2024, 2024 Mar 15;436(6):168449
Temponeras I, Samiotaki M, Koumantou D, Nikopaschou M, Kuiper JJ, Panayotou G, Stratikos E*
Eur J Immunol 2023, Aug;53(8):e2350449
Kuiper JJW, Prinz JC, Stratikos E, ..., Turkstra F*
Ann Rheum Dis 2023, dx.doi.org/10.1136/ard-2022-222852
Georgiadis D*, Skoulikas N, Papakyriakou A, and Stratikos E
ACS Pharmacol. Transl. Sci. 2022, https://doi.org/10.1021/acsptsci.2c00183
Camberlein V, Charlotte FT, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Dumont J, Mpakali A, Giastas P, Herledan A, Couturier C, Haupenthal J, Lesire L, Hirsch AK, Deprez B, Stratikos E, Bouvier M, Deprez-Poulain R*
Angew Chem Int Ed Engl. 2022 Jul 29. doi: 10.1002/anie.202203560
Vourloumis D, Mavridis I, Athanasoulis A, Temponeras I, Koumantou S, Giastas P, Mpakali A, Magrioti V, Leib J, van Endert P, Stratikos E* and Papakyriakou A*
J Med Chem, 2022, Jul 14. doi: 10.1021/acs.jmedchem.2c00904
89. Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Papakyriakou A*, Mpakali A and Stratikos E*
Front Immunol, 2022 Apr 20;13:863529. doi: 10.3389/fimmu.2022.863529
Temponeras I, Stamatakis G, Samiotaki M, Georgiadis D, Pratsinis H, Panayotou G and Stratikos E*
Int J Mol Sci, 2022 in press
87. Inhibitor-Dependent Usage of the S1′ Specificity Pocket of ER Aminopeptidase 2
Mpakali A*, Georgiadis D, Stratikos E, and Giastas P*
ACS Med. Chem. Lett. 2022 in press
86. Tunable Hydrogels with Improved Viscoelastic Properties from Hybrid Polypeptides
Skoulas D, Mangiapia G, Parisi D, Kasimatis M, Glynos E, Stratikos E, Vlassopoulos D, Frielinghaus H, and Iatrou H
Macromolecules, 2021, November 16, 2021, https://doi.org/10.1021/acs.macromol.1c01596.
Stamatakis G, Samiotaki M, Temponeras I, Panayotou G, Stratikos E.*
JBC, 2021, Oct 21:101329. doi: 10.1016/j.jbc.2021.101329.
Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ.
Nature Communications, 2021, Sep 6;12(1):5302. doi: 10.1038/s41467-021-25564-w.
Mavridis G, Mpakali A, Zoidakis J, Makridakis M, Vlahou A, Kaloumenou E, Ziotopoulou A, Georgiadis D, Papakyriakou A and Stratikos E*
Scientific Reports, 2021 Aug 13;11(1):16475. doi: 10.1038/s41598-021-95786-x
Temponeras I, Chiniadis L, Papakyriakou A* and Stratikos E*
Pharmaceuticals 2021, 14(6), 584; https://doi.org/10.3390/ph14060584
81. Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase
Siew Yeen Chai, Hugo Gutiérrez De Teran and Efstratios Stratikos*
Front. Mol. Biosci. 2021 | doi: 10.3389/fmolb.2021.685101
Jonathan P. Hutchinson, Ioannis Temponeras, Jonas Kuiper, Adrian Cortes, Justyna Korczynska, Semra Kitchen and Efstratios Stratikos*
Journal of Biological Chemistry 2021, in press
Kokkala, Paraskevi; Rajeshkumar, Thayalan ; Mpakali, Anastasia; Stratikos, Efstratios; Vogiatzis, Konstantinos; Georgiadis, Dimitris
Organic Letters 2021, in press
W.J. Venema, S. Hiddingh, J.H. de Boer, F.H.J. Claas, A Mulder, A.I. Den Hollander, E. Stratikos, S. Sarkizova, L.T. van der Veken, G.M.C. Janssen, P.A. van Veelen, J.J.W. Kuiper
Frontiers in Immunology 2021, in press
Mpakali, A.*; Stratikos, E.*
Cancers 2021, 13, 134.
Stamatakis G, Samiotaki M, Mpakali A, Panayotou G, Stratikos E*.
J Proteome Res. 2020 Sep 15. doi: 10.1021/acs.jproteome.0c00457. (read paper)
Gkolfinopoulou C, Soukou F, Dafnis I, Kellici TF, Sanoudou D, Mavromoustakos T, Stratikos E & Chroni A*
Cell Mol Life Sci 2020, doi.org/10.1007/s00018-020-03583-y
Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, and Stratikos E*
ACS Med. Chem. Lett. 2020, doi.org/10.1021/acsmedchemlett.0c00172 (DOWNLOAD)
Mavridis G, Arya R, Domnick A, Zoidakis J, Makridakis M, Vlahou A, Mpakali A, Lelis A, Georgiadis D, Tampé R, Papakyriakou A, Stern LJ, Stratikos E*. (Editor's Choice, Cover)
J Biol Chem. 2020 Mar 17. pii: jbc.RA120.012976. doi: 10.1074/jbc.RA120.012976.
72. The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia
Seamon K, Kurlak LO, Warthan M, Stratikos E, Strauss JF 3rd, Mistry HD, Lee ED*.
Front Immunol. 2020. Mar 10;11:396. doi: 10.3389/fimmu.2020.00396. eCollection 2020.
71. Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation. (read here)
Liddle J, Hutchinson JP, Kitchen S, Rowland P, Neu M, Cecconie T, Holmes DS, Jones EJ, Korczynska J, Koumantou D, Lea J, Nickels LA, Pemberton M, Phillipou A, Schneck JL, Sheehan H, Tinworth CP, Uings I, Wojno-Picon J, Young RJ, Stratikos E*.
J Med Chem. 2020 Feb 28. doi: 10.1021/acs.jmedchem.9b02123.
70. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.
Maben Z, Arya R, Rane D, An WF, Metkar S, Hickey M, Bender S, Ali A, Nguyen TT, Evnouchidou I, Schilling RJ, Stratikos E, Golden JE, Stern LJ.
J Med Chem. 2019 Dec 16. doi: 10.1021/acs.jmedchem.9b00293.
69. Mechanism for antigenic peptide selection by ER aminopeptidase 1.
Giastas P#, Mpakali A#, Papakyriakou A, Lelis A, Kokkala P, Neu M, Rowland P, Liddle J, Georgiadis D and Stratikos E*.
PNAS 2019, December 16, 2019 https://doi.org/10.1073/pnas.1912070116.
Karatzas A, Haataja JS, Skoulas D, Bilalis P, Varlas S, Apostolidi P, Sofianopoulou S, Stratikos E, Houbenov N, Ikkala O, Iatrou H.
Biomacromolecules. 2019 Nov 18.
Tsoukalidou S, Kakou M, Mavridis I, Koumantou D, Calderone V, Fragai M, Stratikos E, Papakyriakou A, Vourloumis D.
Bioorg Med Chem. 2019 Nov 1:115177.
66. Editing the immunopeptidome of melanoma cells using a potent inhibitor of Endoplasmic Reticulum aminopeptidase. (read paper here)
Koumantou D, Barnea E, Martin-Esteban A, Maben A, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A and Stratikos E*
Cancer Immunol Immunother 2019, Jun 20. doi: 10.1007/s00262-019-02358-0.
Kuśnierczyk P, Stratikos E.
Hum Immunol. 2019 Mar 27. pii: S0198-8859(19)30296-4. doi: 10.1016/j.humimm.2019.03.011.
64. Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system.
Delimitsou A, Fostira F, Kalfakakou D, Apostolou P, Konstantopoulou I, Kroupis C, Papavassiliou AG, Kleibl Z, Stratikos E, Voutsinas GE, Yannoukakos D.
Hum Mutat. 2019 Mar 9. doi: 10.1002/humu.23728.
Niepiekło-Miniewskaa W,*, Mpakali A,*, Stratikos E, Matusiak L, Narbutt J, Lesiak A, Kuna P, Wilczyńska K, Nowak I, Wiśniewski A, Zwolińska K, Ponińska J, Płoski R, Szepietowskic JC, Kuśnierczyka P
J Eur Acad Dermatol Venereol 2019, Jan 25. doi: 10.1111/jdv.15449
Giastas P, Neu M, Rowland P, Stratikos E*.
ACS Med Chem Lett. 2019 Feb 13;10(5):708-713. doi: 10.1021/acsmedchemlett.9b00002
61. Intracellular Antigen Processing by ERAP2: Molecular Mechanism and Roles in Health and Disease.
de Castro JAL, Stratikos E*.
Hum Immunol. 2018 Nov 7. pii: S0198-8859(18)30785-7. doi: 10.1016/j.humimm.2018.11.001
Salomon E, Schmitt M, Marapaka AK, Stamogiannos A, Revelant G, Schmitt C, Alavi a, Florent I, Addlagatta A, Stratikos E, Tarnus C and Albrecht S*
Molecules 2018, 23(10), 2607; https://doi.org/10.3390/molecules23102607
Katsarou M, Stratikos E*, Chroni A*.
J Lipid Res. 2018 Oct 11. pii: jlr.M088732. doi: 10.1194/jlr.M088732
Bilalis P, Skoulas D, Karatzas A, Marakis J, Stamogiannos A, Tsimblouli C, Sereti E, Stratikos E, Dimas K, Vlassopoulos D, Iatrou H*.
Biomacromolecules. 2018 Aug 27. doi: 10.1021/acs.biomac.8b00959.
57. Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece.
Konstanta I, Fostira F, Apostolou P, Stratikos E, Kalfakakou D, Pampanos A, Kollia P, Papadimitriou C, Konstantopoulou I, Yannoukakos D.
J Hum Genet. 2018 Aug 15. doi: 10.1038/s10038-018-0498-8.
56. Molecular pathways for antigenic peptide generation by ER aminopeptidase 1
Mpakali A, Maben Z, Stern LJ, Stratikos E*.
Mol Immunol 2018, in press, doi.org/10.1016/j.molimm.2018.03.026
55. Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.
Georgiadis D, Mpakali A, Koumantou D, Stratikos E*
Curr Med Chem. 2018 Feb 13. doi: 10.2174/0929867325666180214111849. [Epub ahead of print]
Warthan MD, Washington SL, Franzese SE, Ramus RM, Kim KR, York TP, Stratikos E, Strauss SF III, and Lee ED
Biology of Reproduction 2018, ioy001, https://doi.org/10.1093/biolre/ioy001
53. The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.
Papakyriakou A* and Stratikos E*.
Front Immunol 2017, doi: 10.3389/fimmu.2017.00946
Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E*
J Med Chem. 2017 Mar 22. doi: 10.1021/acs.jmedchem.6b01890
51. The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism.
Vlastaridis P, Papakyriakou A, Chaliotis A, Stratikos E, Oliver SG, Amoutzias GD.
G3 (Bethesda). 2017 Mar 1. pii: g3.116.037218. doi: 10.1534/g3.116.037218.
Mpakali A, Giastas P, Deprez-Poulain R, Papakyriakou A, Koumantou D, Gealageas R, Tsoukalidou S, Vourloumis D, Mavridis IM, Stratikos E and Emmanuel Saridakis
ACS Med. Chem. Lett. 2017 doi: 10.1021/acsmedchemlett.6b00505
Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E*.
Biochemistry. 2017 Feb 20. doi: 10.1021/acs.biochem.6b01170.
Kokkala P, Mpakali A, Mauvais FX, Papakyriakou A, Daskalaki I, Petropoulou I, Kavvalou S, Papathanasopoulou M, Agrotis S, Fonsou TM, van Endert P, Stratikos E*, Georgiadis D*.
J Med Chem 2016, Oct 13;59(19):9107-9123
Dafnis I, Argyri L, Sagnou M, Tzinia A, Tsilibary EC, Stratikos E, Chroni A.
Sci Rep. 2016 Aug 1;6:30654. doi: 10.1038/srep30654.
46. Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.
Stamogiannos A, Papakyriakou A, Mauvais FX, van Endert P, Stratikos E*.
ACS Med Chem Lett. 2016 May 31;7(7):681-5
45. Structural basis for antigenic peptide recognition and processing by ER aminopeptidase 2.
Mpakali A, Giastas P, Mathioudakis N, Mavridis IM, Saridakis E*, Stratikos E*.
J Biol Chem. 2015 Sep 17. pii: jbc.M115.685909.
Mpakali A, Saridakis E, Harlos K, Zhao Y, Papakyriakou A, Kokkala P, Georgiadis D, Stratikos E*.
J Immunol. 2015 Aug 10. pii: 1501103.
43. Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.
Stamogiannos A, Koumantou D, Papakyriakou A*, Stratikos E*.
Mol Immunol. 2015 Jul 26. pii: S0161-5890(15)30019-5.
Gkolfinopoulou C, Stratikos E, Theofilatos D, Kardassis D, Voulgari PV, Drosos AA and Chroni A.
J Rheumatol 2015 Aug 1. pii: jrheum.141532.
Papakyriakou A, Zervoudi E, Tsoukalidou S, Mauvais FX, Sfyroera G, Mastellos DC, van Endert P, Theodorakis E, Vourloumis D* and Stratikos E*.
J Med Chem 2015 Feb 12;58(3):1524-43
Aldhamen YA, Pepelyayeva Y, Rastall DP, Seregin SS, Zervoudi E, Koumantou D, Aylsworth CF, Quiroga D, Godbehere S, Georgiadis D, Stratikos E, Amalfitano A.
J Innate Immun. 2015 Jan 14.
Stratikos, E*, Stamogiannos, A., Zervoudi, E., Fruci, D.
Front. Oncol. 2014 4:363. doi: 10.3389/fonc.2014.00363
Stratikos E*.
Curr Opin Chem Biol. 2014 Aug 28;23C:1-7
Argyri L, Dafnis I, Theodossiou TA, Gantz D, Stratikos E*, Chroni A*.
J Biol Chem. 2014 Mar 18.
36. Modulating antigen processing for cancer immunotherapy.
Stratikos E*.
OncoImmunology, 2014 Volume 3, Issue 1, e27568.
Zervoudi E, Saridakis E, Birtley JR, Seregin S., Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D* and Stratikos E*.
Proc Natl Acad Sci USA, 2013 Dec 3;110(49):19890-5.
34. Significance of the hydrophobic residues 225 to 230 of apoA-I for the biogenesis of HDL.
Fotakis P, Tiniakou I, Kateifides AK, Gkolfinopoulou C, Chroni A, Stratikos E, Zannis VI, Kardassis D.
J Lipid Res. 2013 Oct 12. [Epub ahead of print]
Stratikos E, Chroni A.
Clin Exp Nephrol. 2013 Oct 23 [Epub ahead of print]
Seregin SS, Rastall DP, Evnouchidou I, Aylsworth CF, Quiroga D, Kamal RP, Godbehere-Roosa S, Blum CF, York IA, Stratikos E, Amalfitano A.
Autoimmunity. 2013 Sep 13. [Epub ahead of print]
Fotakis P, Kateifides A, Gkolfinopoulou C, Georgiadou D, Beck M, Grundler K, Chroni A, Stratikos E, Kardassis D, Zannis VI.
J Lipid Res. 2013 Aug 29. [Epub ahead of print]
30. Novel selective inhibitors of aminopeptidases that generate antigenic peptides.
Papakyriakou A, Zervoudi E, Theodorakis EA, Saveanu L, Stratikos E, Vourloumis D.
Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6.
Derek L. Vanhille, Lori D. Hill, DaShaunda D. Hilliard, Eun D. Lee, Maria E. Teves, Sindhu Srinivas, Juan P. Kusanovic, Ricardo Gomez, Efstratios Stratikos, Michal A. Elovitz, Roberto Romero, Jerome F. Strauss III*
Mol Gen & Gen Med. 2013, v.1, pp 98-107.
28. Antigenic peptide trimming by ER aminopeptidases-Insights from structural studies.
Stratikos E*, Stern LJ*.
Mol Immunol. 2013 Oct;55(3-4):212-9.
Georgiadou D, Chroni A, Drosatos K, Kypreos KE, Zannis VI, Stratikos E*
Atherosclerosis 2013 Feb;226(2):385-91.
Georgiadou D, Stamatakis K, Efthimiadou E, Kordas G, Gantz D, Chroni A*, Stratikos E*.
J Lipid Res. 2013 Jan;54(1):164-76. (PDF)
Duka A, Fotakis P, Georgiadou D, Kateifides A, Tzavlaki K, von Eckardstein L,Stratikos E, Kardassis D, Zannis VI.
J Lipid Res. 2013 Jan;54(1):107-15.
Evnouchidou I, Birtley J, Seregin S, Papakyriakou A, Zervoudi E, Samiotaki M, Panayotou G, Giastas P, Petrakis O, Georgiadis D, Amalfitano A, Saridakis E, Mavridis IM and Stratikos E*
J Immunol. 2012, Sep 1;189(5):2383-92. (PDF)
Birtley JR, Saridakis E, Stratikos E*, Mavridis IM*.
Biochemistry 2012 Jan 10;51(1):286-95. (PDF)
Georgiadou D, Chroni A, Vezeridis A, Zannis VI and Stratikos E*
PLoS ONE, 2011;6(11):e27037 (PDF)
Kim S, Lee S, Shin J, Kim Y, Evnouchidou I, Kim D, Kim YK, Kim YE, Ahn JH, Riddell SR, Stratikos E, Kim VN, Ahn K.
Nat Immunol. 2011 Sep 4. doi: 10.1038/ni.2097. (PDF)
20. A simple approach for human recombinant apolipoprotein E4 expression and purification.
Argyri L, Skamnaki V, Stratikos E, Chroni A.
Protein Expr Purif. 2011 Jun 25. (PDF)
19. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E*
Biochem J. 2011 Feb 11. (PDF)
Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, Goldberg AL, Stratikos E, Stern LJ.
Nat Struct Mol Biol. 2011 Apr 10. (PDF)
Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E*
J Immunol. 2011 Feb 15;186(4):1909-13. (PDF)
Georgiadou D, Hearn A, Evnouchidou I, Chroni A, Leondiadis L, York IA, Rock KL, Stratikos E*
J Immunol. 2010 Aug 1;185(3):1584-92. (PDF)
15. An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42.
Dafnis I, Stratikos E, Tzinia A, Tsilibary EC, Zannis VI, Chroni A.
J Neurochem. 2010 Nov;115(4):873-84. (PDF)
Evnouchidou I, Berardi MJ, Stratikos E*
Anal Biochem. 2009 Dec 1;395(1):33-40. (PDF)
13. A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.
Evnouchidou I, Papakyriakou A, Stratikos E*
Curr Pharm Des. 2009;15(31):3656-70. (PDF)
12. Cellular mechanisms that edit the immunopeptidome and modulate the immune response.
Georgiadou D and Stratikos E*
Current Proteomics, 2009, v.6 (1). (PDF)
11. The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
Evnouchidou I, Momburg F, Papakyriakou A, Chroni A, Leondiadis L, Chang SC, Goldberg AL, Stratikos E*
PLoS One. 2008;3(11):e3658. (PDF)
Chroni A, Pyrpassopoulos S, Thanassoulas A, Nounesis G, Zannis VI, Stratikos E*
Biochemistry. 2008 Sep 2;47(35):9071-80. (PDF)
Stratikos E*, Wiley DC, Stern LJ.
J Immunol. 2004 Jan 15;172(2):1109-17. (PDF)
Stratikos E*, Mosyak L, Zaller DM, Wiley DC.
J Exp Med. 2002 Jul 15;196(2):173-83. (PDF)
Backovic M, Stratikos E, Lawrence DA, Gettins PG.
Protein Sci. 2002 May;11(5):1182-91. (PDF)
Stratikos E, Gettins PG.
PNAS USA. 1999 Apr 27;96(9):4808-13. (PDF)
Futamura A, Stratikos E, Olson ST, Gettins PG.
Biochemistry. 1998 Sep 22;37(38):13110-9. (PDF)
Stratikos E, Gettins PG.
J Biol Chem. 1998 Jun 19;273(25):15582-9. (PDF)
3. Major proteinase movement upon stable serpin-proteinase complex formation.
Stratikos E, Gettins PG.
PNAS USA. 1997 Jan 21;94(2):453-8. (PDF)
Stratikos E, Alberdi E, Gettins PG, Becerra SP.
Protein Sci. 1996 Dec;5(12):2575-82. (PDF)
Konstantianos DG, Ioannou PC, Stratikos E.
Analytica Chimica Acta, 290 (1994) 34-39. (PDF)
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