Total citation counts: 11691 (Google Scholar; updated on July 13, 2025)
h-index: 16
*Co-first author #Corresponding/Co-corresponding author
In submission:
Wu, C., Yi, J., Liu, H., Xie, J., Liu, H., Chen, Z.S., Wang, X., Zhou, Y., Li, C. and Jiang, C.
Ou, M., Chen, Z.S., Wang, E., Zhu, Y., Talbot, K., Guo, P., Ngo, J.C.K. and Chan, H.Y.E.
Jing, S., Wu, Z., Xu, Y., He, T., Gou, S., Lu, Y., Lin, M., Wang, A., Dai, Y., Hu, H., Cui, X., Chen, Z.S., Shi, X., Qiu, J., Guo, Q., Zhou, Y., Li, C. and Jiang, C.
Under revision:
Koon, A.C.*, Yeung, K.Y.W.*, Wu, Y., Leong, L.I., Cheung, J.T.P., Chen, Z.S., Peng, S.I., Armstrong, N.S., Frank, C.A., Magneron, P., Gomes-Pereira, M., Fung, J.M.S., Bargiela, A., Moreno, N., Poyatos, J., Vilchez, J., Huguet, A., Brewer, C.K., Zinter, M., Beck, E.S., Artero, R., Gourdon, G., Budnik, V., Thomson, T., McCabe, B.D. and Chan, H.Y.E. Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy. (Preprint: https://www.biorxiv.org/content/10.1101/2024.05.26.595976v1)
Published:
2025
Chen, Z.S.*, Peng, S.I.*, Leong, L.I., Gall-Duncan, T., Wong, N.S.J., Li, T.H., Lin, X., Wei, Y., Koon, A.C., Huang, J., Sun, J.K.L., Turner, C., Tippett, L., Curtis, M.A., Faull, R.L.M., Kwan, K.M., Chow, H.M., Ko, H., Chan, T.F., Talbot, K., Pearson, C.E. and Chan, H.Y.E. (2025) Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5. Nat. Commun. 16(1), 3307. DOI: https://doi.org/10.1038/s41467-025-58618-4.
2023
Chen, Z.S., Ou, M., Taylor, S., Dafinca, R., Peng, S.I., Talbot, K. and Chan, H.Y.E. (2023) Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD. Nat. Commun. 14(1), 8420. DOI: https://doi.org/10.1038/s41467-023-44215-w.
2022
Liu, Y., Wang, X., Wu, Q., Pei, W., Teo, M.J., Chen, Z.S.# and Huang, C.# (2022) Application of lignin and lignin-based composites in different tissue engineering fields. Int. J. Biol. Macromol. 222, 994-1006. DOI: https://doi.org/10.1016/j.ijbiomac.2022.09.267.
Chan, H.Y.E.# and Chen, Z.S.# (2022) Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma. Aging 14(19), 7794-7823. DOI: https://doi.org/10.18632/aging.204262.
Chen, Z.S., Yan, M., Pei, W., Yan, B., Huang, C. and Chan, H.Y.E. (2022) Lignin-carbohydrate complexes suppress SCA3 neurodegeneration via upregulating proteasomal activities. Int. J. Biol. Macromol. 218, 690-705. DOI: https://doi.org/10.1016/j.ijbiomac.2022.07.133.
Peng, S.I., Leong, L.I., Sun, J.K.L., Chen, Z.S., Chow, H.M. and Chan, H.Y.E. (2022) A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities. Mol. Ther. Nucleic Acids 29, 102-115. DOI: https://doi.org/10.1016/j.omtn.2022.06.004.
An, Y., Chen, Z.S., Chan, H.Y.E. and Ngo, J.C.K. (2022) Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases. Nucleic Acids Res. 50(13), 7655-7668. DOI: https://doi.org/10.1093/nar/gkac532.
Hu, Y., Yan, B., Chen, Z.S., Wang, L., Tang, W. and Huang, C. (2022) Recent technologies for the extraction and separation of polyphenols in different plants: a review. J. Renew. Mater. 10(6), 1471-1490. DOI: https://doi.org/10.32604/jrm.2022.018811.
2021
Yan, B.*, Chen, Z.S.*, Hu, Y. and Yong, Q. (2021) Insight in the recent application of polyphenols from biomass. Front. Bioeng. Biotechnol. 9, 753898. DOI: https://doi.org/10.3389/fbioe.2021.753898.
Klionsky, D.J. ... Chen, Z.S. ...Tong, C.K. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1), 1-382. DOI: https://doi.org/10.1080/15548627.2020.1797280.
Yahia, A.*, Chen, Z.S.*, Ahmed, A.E., Emad, S., Adil, R., Abubaker, R., Taha, S.O.M.A., Salih, M.A., Elsayed, L., Chan, H.Y.E. and Stevanin, G. (2021) A heterozygous mutation in the CCDC88C gene likely causes early-onset pure hereditary spastic paraplegia: a case report. BMC Neurol. 12(1), 78. DOI: https://doi.org/10.1186/s12883-021-02113-y.
Peng, S., Guo, P., Lin, X., An, Y., Sze, K.H., Lau, M.H.Y., Chen, Z.S., Wang, Q., Li, W., Sun, J.K.L., Ma, S.Y., Chan, T.F., Lau, K.F., Ngo, J.C.K., Kwan, K.M., Wong, C.H., Lam, S.L., Zimmerman, S.C., Tuccinardi, T., Zuo, Z., Au-Yeung, H.Y., Chow, H.M. and Chan, H.Y.E. (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. Proc. Natl. Acad. Sci. USA. 118(19), e2022940118. DOI: https://doi.org/10.1073/pnas.2022940118.
Chen, Z.S.*#, Lin, X.*, Chan, T.F. and Chan, H.Y.E.# (2021) Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis. Aging 13(5), 7259-7283. DOI: https://doi.org/10.18632/aging.202582.
Chen, Z.S., Huang, X., Talbot, K. and Chan, H.Y.E. (2021) A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Cell Death Dis. 12(2), 136. DOI: https://doi.org/10.1038/s41419-021-03444-x.
2020
Pei, W.*, Chen, Z.S.*, Chan, H.Y.E., Zheng, L., Liang, C. and Huang, C. (2020) Isolation and identification of a novel anti-protein aggregation activity of lignin-carbohydrate complex from Chionanthus retusus leaves. Front. Bioeng. Biotechnol. 8, 573991. DOI: https://doi.org/10.3389/fbioe.2020.573991.
2019
Zhang, Q., An, Y., Chen, Z.S., Koon, A.C., Lau, K.F., Ngo, J.C.K. and Chan, H.Y.E. (2019) A peptidylic inhibitor for neutralizing r(GGGGCC)exp-associated neurodegeneration in C9ALS-FTD. Mol. Ther. Nucleic Acids 16, 172-185. DOI: https://doi.org/10.1016/j.omtn.2019.02.015.
Chen, Z.S.# and Chan, H.Y.E. (2019) Transcriptional dysregulation in neurodegenerative diseases: who tipped the balance of Yin Yang 1 in the brain? Neural Regen. Res. 14(7), 1148-1151. DOI: https://doi.org/10.4103/1673-5374.251193.
Chen, Z.S.*, Wong, A.K.Y.*, Cheng, T.C., Koon, A.C. and Chan, H.Y.E. (2019) FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. J. Neurochem. 149(6), 781-798. DOI: https://doi.org/10.1111/jnc.14669.
Hong, H.*, Koon, A.C.*, Chen, Z.S.*, Wei, Y., An, Y., Li, W., Lau, M.H.Y., Lau, K.F., Ngo, J.C.K., Wong, C.H., Au-Yeung, H.Y., Zimmerman, S.C. and Chan, H.Y.E. (2019) AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. J. Biol. Chem. 294(8), 2757-2770. DOI: https://doi.org/10.1074/jbc.RA118.006307.
Leńska-Mieciek, M., Charzewska, A., Królicki, L., Hoffman-Zacharska, D., Chen, Z.S., Lau, K.F., Chan, H.Y.E., Gambin, T. and Fiszer, U. (2019) Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene. Mov. Disord. 34(1), 142-144. DOI: https://doi.org/10.1002/mds.27536.
2018
Koon, A.C., Chen, Z.S., Peng, S., Fung, J.M.S., Zhang, X., Lembke, K.M., Chow, H.K., Frank, C.A., Jiang, L., Lau, K.F. and Chan, H.Y.E. (2018) Drosophila Exo70 is essential for neurite extension and survival under thermal stress. J. Neurosci. 38(37), 8071-8086. DOI: https://doi.org/10.1523/JNEUROSCI.0620-18.2018.
Chen, Z.S., Li, L., Peng, S., Chen, F.M., Zhang, Q., An, Y., Lin, X., Li, W., Koon, A.C., Chan, T.F., Lau, K.F., Ngo, J.C.K., Wong, W.T., Kwan, K.M. and Chan, H.Y.E. (2018) Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models. EMBO Rep. 19(9), e45409. DOI: https://doi.org/10.15252/embr.201745409.
Zhang, Q., Chen, Z.S., An, Y., Liu, H., Hou, Y., Li, W., Lau, K.F., Koon, A.C., Ngo, J.C.K. and Chan, H.Y.E. (2018) A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases. RNA 24(4), 486-498. DOI: http://www.rnajournal.org/cgi/doi/10.1261/rna.062703.117.
2014
Tsoi, H., Li, L., Chen, Z.S., Lau, K.F., Tsui, S.K.W. and Chan, H.Y.E. (2014) The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1–PKB/Akt signalling. Biochem. J. 464(3), 439-447. DOI: https://doi.org/10.1042/BJ20131461.
Tsoi, H., Yu, A.C.S., Chen, Z.S., Ng, N.K.N., Chan, A.Y.Y., Yuen, L.Y.P., Abrigo, J.M., Tsang, S.Y., Tsui, S.K.W., Tong, T.M.F., Lo, I.F.M., Lam, S.T.S., Mok, V.C.T., Wong, L.K.S., Ngo, J.C.K., Lau, K.F., Chan, T.F. and Chan, H.Y.E. (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51(9), 590-595. DOI: http://dx.doi.org/10.1136/jmedgenet-2014-102333.
Zhou, X., Sun, J., Ma, W., Fang, W., Chen, Z., Yang, B. and Liu, Y. (2014) Bioactivities of six sterols isolated from marine invertebrates. Pharm. Biol. 52(2), 187-190. DOI: https://doi.org/10.3109/13880209.2013.821664.
Zhou, X., Liu, X., Ma, W., Fang, W., Chen, Z., Yang, B. and Liu, Y. (2014) A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochem. Lett. 7, 35-37. DOI: https://doi.org/10.1016/j.phytol.2013.09.010.