Klebsiella pneumoniae (Institut Pasteur)
The oqxB resistance gene is an efflux pump (CARD), or more simply, a pump. This pump is in the cell membrane of the bacteria. When antibiotics get inside bacteria, this gene allows the bacteria to pump antibiotics back out of the cell.
This gene has been found in Klebsiella pneumoniae (NIH National Library of Medicine).
Klebsiella pneumoniae causes pneumonia, urinary tract infections, and liver abscess (Diagnostic Pathology: Infectious Diseases).
Soil-Seq students found oqxB in a Burkholderia species. Burkholderia commonly cause infections in healthcare settings (CDC).
ECM-1 is an ECM beta lactamase. Beta lactamases provide multi-drug resistance, meaning a variety of antibiotics that are commonly used to treat infections no longer work when beta lactamases are present.
This gene has been documented in E. coli and Shigella. You've probably heard of E. coli, it lives in everyone's guts, but some types or strains of E. coli can make us sick with diarrhea.
Soil-Seq found this gene in an organism within the taxid Bacteria, meaning we know it is a bacteria, but do not know what species.
E. coli (National Geographic)
Tetracycline antibiotic (Wikimedia Commons)
The tet(V) resistance gene works as an antibiotic efflux pump, similarly to AxyY (described above), it pumps antibiotics back out of the bacterial cell.
The gene tet(V) has been found in Mycolicibacterium smegmatis and Mycolicibacterium fortuitum (CARD). Soil-Seq found the gene in an unclassified organism.
tet(V) is part of a class of antibiotic resistance genes that are resistant to Tetracyclines, a type of antibiotic. Other members of this class, such as tetB or tetC, are much more clinically relevant and commonly found (Bryan et al., 2004).