Oral and maxillofacial diseases are not isolated local conditions. Many orofacial diseases share biological, genetic, inflammatory, and metabolic links with systemic diseases. Our lab investigates these connections using human genomics, clinical data, and experimental approaches to better understand the broader biological significance of oral diseases.

Key Questions

• Are orofacial diseases genetically connected to systemic diseases?

• Which biological pathways are shared between oral and systemic conditions?

• Can oral diseases provide insight into systemic disease mechanisms?

• How can human genetics clarify whether observed disease associations are causal or shared?

Approaches

• Large-scale genomic analysis of oral and maxillofacial diseases

• Cross-disease genetic correlation analysis

• Mendelian randomization and causal inference

• Multi-omics integration

• Functional interpretation of candidate genes and pathways

• Experimental validation of disease mechanisms

Research Topics

• Genetic architecture of oral and maxillofacial diseases

• Oral-systemic disease connections

• Periodontitis and systemic inflammatory/metabolic diseases

• Dental caries, TMD, salivary gland disease, and systemic traits

• Functional studies of candidate genes from human genetic analysis

Keywords

Orofacial disease, oral-systemic connection, periodontitis, dental caries, TMD, salivary gland disease, human genetics, systemic disease