Our lab uses large-scale human genomic and multi-omics data to understand the genetic architecture of complex diseases and identify disease-associated genes, pathways, and therapeutic targets. By integrating genomics, transcriptomics, proteomics, and clinical phenotypes, we aim to move beyond statistical associations toward biological interpretation and translational insight.

Key Questions

• What genetic factors contribute to complex human diseases?

• How are orofacial diseases genetically connected to systemic diseases?

• Can human genetic data help identify causal genes, pathways, and therapeutic targets?

• How can multi-omics data improve our understanding of disease mechanisms?

Approaches

• Genome-wide association study, GWAS

• Whole-exome sequencing analysis

• Gene-based rare variant analysis

• Mendelian randomization

• Genetic correlation and cross-trait analysis

• Transcriptomic and proteomic integration

• Functional interpretation of disease-associated variants

Research Topics

• Integrative genomic analysis of orofacial diseases

• Genetic links between oral and systemic diseases

• Serum biomarker and proteomic analysis of systemic disease traits

• Discovery of disease-associated genes and therapeutic targets

• Functional prioritization of genetic findings

Keywords

Human genetics, GWAS, exome sequencing, Mendelian randomization, multi-omics, proteomics, genetic correlation, target discovery