Cardiovascular and metabolic diseases are closely linked to lipid metabolism, inflammation, vascular biology, and systemic metabolic regulation. Our lab investigates the molecular mechanisms underlying atherosclerosis and metabolic disease by combining human genomic analysis, disease models, and experimental biology.

Key Questions

• How do lipid metabolism and systemic metabolic factors contribute to cardiovascular disease?

• Can human genetics reveal new mechanisms of atherosclerosis?

• How are cardiovascular and metabolic diseases connected to bone and orofacial diseases?

• Can disease-associated molecular pathways be translated into therapeutic targets?

Approaches

• Human genomic analysis of cardiovascular and metabolic traits

• Animal models of atherosclerosis and metabolic disease

• Molecular studies of lipid metabolism

• Cell-based functional assays

• Cross-disease genetic and mechanistic analysis

• Translational target discovery

Research Topics

• Atherosclerosis and vascular disease mechanisms

• Cholesterol metabolism and lipid regulation

• Cardiovascular disease genetics

• Metabolic disease mechanisms

• Experimental studies of cardiovascular disease

• Links between cardiovascular, metabolic, bone, and oral disease biology

Keywords

Atherosclerosis, cardiovascular disease, lipid metabolism, cholesterol metabolism, metabolic disease, human genetics, animal model, target discovery