Research
The focus of our research is to create better clinical assays by developing innovative technologies and reagents that improve assay analytical performance. These technologies integrate diverse disciplines including polymer chemistry, biomaterials, biophysics, clinical chemistry, and transport phenomena. Physicians rely on clinical diagnostic tests to make medical decisions and provide effective treatments. Assays with higher sensitivity and shorter run times are needed to enable rapid diagnoses and timely treatments for more patients, and to help prevent pandemics such as COVID-19. To improve the sensitivity, specificity, speed, and multiplexing of diagnostic assays, we develop novel stimuli-responsive, "smart" polymer reagents to capture and quantify biomarkers for clinical diagnostic assays, life science research, and biologics manufacturing. Additionally, we also develop microfluidic devices that can be utilized in conjunction with the smart polymer reagents for biomarker isolation and detection.
The focus of our research is to create better clinical assays by developing innovative technologies and reagents that improve assay analytical performance. These technologies integrate diverse disciplines including polymer chemistry, biomaterials, biophysics, clinical chemistry, and transport phenomena. Physicians rely on clinical diagnostic tests to make medical decisions and provide effective treatments. Assays with higher sensitivity and shorter run times are needed to enable rapid diagnoses and timely treatments for more patients, and to help prevent pandemics such as COVID-19. To improve the sensitivity, specificity, speed, and multiplexing of diagnostic assays, we develop novel stimuli-responsive, "smart" polymer reagents to capture and quantify biomarkers for clinical diagnostic assays, life science research, and biologics manufacturing. Additionally, we also develop microfluidic devices that can be utilized in conjunction with the smart polymer reagents for biomarker isolation and detection.
Stimuli-responsive, "smart" polymers respond sharply and reversibly to small changes in temperature, pH, or other physical or chemical stimuli by changing their conformation and physicochemical properties (for example, from a hydrophilic state to a hydrophobic state). Stimuli-responsive polymers have been used in various biomedical applications.
Stimuli-responsive, "smart" polymers respond sharply and reversibly to small changes in temperature, pH, or other physical or chemical stimuli by changing their conformation and physicochemical properties (for example, from a hydrophilic state to a hydrophobic state). Stimuli-responsive polymers have been used in various biomedical applications.
