Pharmaceutical Formulation & Stabilization
Pharmaceutical Formulation & Stabilization
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In this research area, we focus on pharmaceutical formulation and stabilization strategies for advanced therapeutics with particular emphasis on lyophilized injectable formulations and oral dosage forms.
In this research area, we focus on pharmaceutical formulation and stabilization strategies for advanced therapeutics with particular emphasis on lyophilized injectable formulations and oral dosage forms.
We systematically investigate how formulation components, excipients, and processing conditions influence the conformational stability, aggregation behavior, and reconstitution performance of proteins, peptides, RNA therapeutics, and nanomaterial-based systems.
We systematically investigate how formulation components, excipients, and processing conditions influence the conformational stability, aggregation behavior, and reconstitution performance of proteins, peptides, RNA therapeutics, and nanomaterial-based systems.
Our work on lyophilized formulations addresses critical challenges, including long-term stability, cold-chain independence, and usability in resource-limited or extreme environments. By utilizing nanostructured carriers/protective formulations, and optimizing freeze–drying cycles, cryo-/lyoprotectant systems, and reconstitution kinetics, we design stable injectable formulations suitable for both terrestrial healthcare and space medicine applications.
Our work on lyophilized formulations addresses critical challenges, including long-term stability, cold-chain independence, and usability in resource-limited or extreme environments. By utilizing nanostructured carriers/protective formulations, and optimizing freeze–drying cycles, cryo-/lyoprotectant systems, and reconstitution kinetics, we design stable injectable formulations suitable for both terrestrial healthcare and space medicine applications.
In parallel, we develop oral drug delivery systems for advanced therapeutics, focusing on overcoming gastrointestinal barriers through the use of microstructured scaffolds, additive formulations, and mucus-interacting or mucus-penetrating strategies. These approaches aim to enhance oral bioavailability and expand non-invasive administration routes for biomolecular and nanopharmaceutical agents.
In parallel, we develop oral drug delivery systems for advanced therapeutics, focusing on overcoming gastrointestinal barriers through the use of microstructured scaffolds, additive formulations, and mucus-interacting or mucus-penetrating strategies. These approaches aim to enhance oral bioavailability and expand non-invasive administration routes for biomolecular and nanopharmaceutical agents.
Through the integration of advanced analytical and biophysical characterization, this research establishes formulation-informed design principles that bridge the gap between fundamental pharmaceutical science and translational drug development. Ultimately, our formulation research provides a practical foundation that enables the clinical and real-world deployment of next-generation therapeutics developed across all research areas of the laboratory.
Through the integration of advanced analytical and biophysical characterization, this research establishes formulation-informed design principles that bridge the gap between fundamental pharmaceutical science and translational drug development. Ultimately, our formulation research provides a practical foundation that enables the clinical and real-world deployment of next-generation therapeutics developed across all research areas of the laboratory.
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