Programmable Biomolecular Therapeutics
Programmable Biomolecular Therapeutics
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In this research area, we develop advanced nanoplatforms for programmable biomolecular therapeutics, encompassing RNA therapeutics, peptide drugs, and protein-based medicines, with the goal of achieving precise and controllable regulation of cellular functions.
In this research area, we develop advanced nanoplatforms for programmable biomolecular therapeutics, encompassing RNA therapeutics, peptide drugs, and protein-based medicines, with the goal of achieving precise and controllable regulation of cellular functions.
By engineering porous and functional nanomaterials, we enable the controlled intracellular trafficking and programmable release of RNA and CRISPR cargos, allowing for precise post-transcriptional and gene–editing–based modulation of cellular pathways.
By engineering porous and functional nanomaterials, we enable the controlled intracellular trafficking and programmable release of RNA and CRISPR cargos, allowing for precise post-transcriptional and gene–editing–based modulation of cellular pathways.
Our work addresses key challenges in next-generation gene therapy, including the spatiotemporal control of gene editing, minimization of off-target effects, multi-target regulation, and coordinated action across multiple cellular compartments, as well as the development of adjuvants and vaccines.
Our work addresses key challenges in next-generation gene therapy, including the spatiotemporal control of gene editing, minimization of off-target effects, multi-target regulation, and coordinated action across multiple cellular compartments, as well as the development of adjuvants and vaccines.
These approaches provide a foundation for future personalized and N-of-1 therapeutic strategies, where biomolecular therapeutics can be tailored to patient-specific genetic or molecular profiles.
These approaches provide a foundation for future personalized and N-of-1 therapeutic strategies, where biomolecular therapeutics can be tailored to patient-specific genetic or molecular profiles.
This research establishes a versatile and extensible framework for biomolecular therapeutics, supporting applications in cancer therapy, immune modulation, regenerative medicine, and the treatment of rare or genetically defined diseases.
This research establishes a versatile and extensible framework for biomolecular therapeutics, supporting applications in cancer therapy, immune modulation, regenerative medicine, and the treatment of rare or genetically defined diseases.
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