ROS Modulation & Nanozyme-Based Therapeutic Systems 

In this research area, we focus on the development of nanozyme-based therapeutic systems that enable precise and bidirectional modulation of ROS, allowing controlled regulation of cellular fate and tissue responses.

By engineering functional nanozymes and redox-responsive nanomaterials, we design platforms capable of both ROS scavenging and ROS generation, enabling fine control over redox signaling pathways involved in inflammation, angiogenesis, immune activation, and non-apoptotic cell death mechanisms.

A crucial component of this research is the development of nanocarrier systems for poorly soluble photosensitizers, which enable efficient delivery, stabilization, and controlled activation of photodynamic agents. Through these systems, we integrate photodynamic therapy (PDT) as a spatiotemporally controllable approach for localized ROS generation, allowing selective therapeutic action while minimizing off-target damage.

A distinctive aspect of this research is the integration of ROS modulation with microenvironmental cues, such as hypoxia, inflammation, metabolic stress, and light activation, enabling therapeutic systems to respond selectively to disease-specific conditions rather than normal tissues.

This research establishes ROS modulation as a programmable therapeutic axis, providing versatile nanozyme- and photodynamic-based platforms applicable to cancer therapy, inflammatory diseases, tissue regeneration, and stress-related pathologies under both terrestrial and extreme environments.