Programmable Biomolecular Therapeutics
In this research area, we develop advanced nanoplatforms for programmable biomolecular therapeutics, including DNA/RNA therapeutics, peptide drugs, and protein-based medicines, with the goal of achieving precise, controllable regulation of cellular functions.
By engineering porous and functional nanomaterials, we enable the controlled intracellular trafficking and programmable release of RNA and CRISPR cargos, allowing for precise post-transcriptional and gene–editing–based modulation of cellular pathways.
Our work addresses key challenges in next-generation gene therapy, including spatiotemporal control of gene editing, minimization of off-target effects, multi-target regulation, coordinated action across multiple cellular compartments, and the development of adjuvants and vaccines.
These approaches provide a foundation for future personalized and N-of-1 therapeutic strategies, where biomolecular therapeutics can be tailored to patient-specific genetic or molecular profiles.
This research establishes a versatile and extensible framework for biomolecular therapeutics, supporting applications in cancer therapy, immune modulation, regenerative medicine, and the treatment of rare or genetically defined diseases.