Our research focuses on developing chemical and synthetic biology tools for molecular level understanding of the histone code with implications in fundamental science and drug discovery. My group develops cyclic peptide-based ligands to modulate specific epigenetic PTM states of histones both in vitro and in vivo. We aim to mimic the epigenetic modifications of histones e.g. methylation, acetylation, ubiquitination using genetic code expansion and protein semisynthesis technique to understand the molecular basis of crosstalks and their roles in controlling the chromatin landscape.