Jarak I
Short Biography:
Ivana Jarak obtained her LSc and MSc degrees in Chemistry at the University of Zagreb, Croatia. In 2005 she was conferred a PhD degree in Chemistry at the Faculty of Chemical Engineering and Technology, University of Zagreb with special interest in the fields of organic synthetic, medicinal and macromolecular chemistry, developing nucleic acid targeting drugs. After two years in pharmaceutical clinical research organization, Parexel International, she focused her interest on metabolism and the application of labelled tracers in the study of metabolic fluxes in cellular, animal and human models using nuclear magnetis resonance (NMR) and mass spectroscopy (MS). During a Post-Doctoral fellowship at the University of Aveiro under the supervision of Dr. Iola Duarte she started to work in the area of metabolomic profiling and its implementation in the research of metabolome of cell and tissue extracts, and intact tissues (biopsies) as a consequence of disease, nutrition or pharmacological treatment. Her recent interests are male fertility and obesity.
Funded projects:
PTDC/BIM-MET/4712/2014: Obesitility - Gut hormones and testicular metabolism: mechanisms associated with obesity-related male infertility, FCT, Portugal (PI: Marco G. Alves)
IP-06-2016: DietMetSyn - Dietary lipids, sex and age in pathogenesis of metabolic syndrome, Croatian Science Foundation, Croatia (PI: Kristina Starcevic)
Ended funded projects:
PTDC/SAU-TOX/120953/2010: Metabolic profiling: a novel tool for evaluation of the toxicological and biological effects of nanomaterials, FCT, Portugal (PI: Iola F. Duarte).
PTDC/EBB-EBI/115810/2009: Unraveling cancer metabolism and tumor growth through flux analysis and metabolic engineering, FCT, Portugal (PI: Rui A. Carvalho).
PTDC/SAU-MET/111398/2009: Role of the intestine in promoting the lipogenic effects of fructose, FCT, Portugal (PI: John G. Jones).
PTDC/EBB-BIO/098111/2008: Optimizing carbohydrate utilization in farmed sea-bass through metabolic profiling, FCT, Portugal (PI: John G. Jones).
PTDC/EBB-EBI/101114/2008: Effect of immunosuppressive agents on glucose and lipid metabolism: implications for diagnosis and therapy of post-transplant diabetes, FCT, Portugal (PI: John G. Jones).
PTDC/SAU-OSM/098569/2008: Molecular mechanisms of insulin resistance after immunosuppressive therapy, FCT, Portugal (PI: Eugénia Carvalho)
Novel Heterocycles as antitumor and antiviral (smart) drugs, Faculty of Chemical Engineering and Technology, Financed by Ministry of Science, Education and Sport of the Republic of Croatia; No. 125-0982464-1356 (PI: Grace Karminski-Zamola)
New heterocycles; Synthesis, antitumor and antiinfective activity, Faculty of Chemical Engineering and Technology, Financed by Ministry of Science, Education and Sport of the Republic of Croatia; No. 0125005 (PI: Grace Karminski-Zamola)
Synthesis of non-nucleoside heterocycles for HIV-treatment, Faculty of Chemical Engineering and Technology, Financed by Ministry of Science, Education and Sport of the Republic of Croatia; No. 125005 (PI: Grace Karminski-Zamola)
Fellowships and Prizes:
2018: Best Poster in Basic Research, "High-fat diets compromise male fertility which is not recovered by diet reversion", the 14th Portuguese Congress of Diabetes, Hotel Tivoli Marina Vilamoura, Vilamoura, Portugal, 9-11 March 20182013: 2-year Post-Doctoral fellowship at the Centre for Research in Ceramics and Composite Materials (CICECO), University of Aveiro, Portugal
2012: 1-year Post-Doctoral fellowship at the Center for Neuroscience and Cell Biology, Coimbra, Portugal
2010: Fellowship to participate in the 2nd NATO ASI Summer school, 10th Course: Biophysics and Structure, Erice, Italy, June 2010.
Proceedings in Peer-reviewed Journals:
Book chapters:
Publications:
28. Jarak I, Carrola J, Barros AS, Gil AM, Pereira ML, Corvo ML, Duarte IF (2017) Metabolism modulation in different organs by silver nanoparticles: An NMR metabolomics study of a mouse model.Toxicol Sci, 59(2):422-435. doi: 10.1093/toxsci/kfx142.
27. Costa PJ, Jarak I, Albuquerque CR. (2017) Resolving NMR signals of short chain fatty acid mixtures using Unsupervised Component Analysis. Magn Reson Chem 55(10):936-943. doi: 10.1002/mrc.4606.
26. Fonseca R, Carvalho RA, Lemos C, Sequeira AC, Pita IR, Carvalho F, Silva CD, Prediger RD, Jarak I, Cunha RA, Fontes Ribeiro CA, Kofalvi A, Pereira FC. (2017) Speeding and slowing: methamphetamine induces anhedonia and impairs frontal cortical energetics in mice. CNS Neurosci Ther 23, 119-126. doi: 10.1111/cns.
25. Zlatar I, Jelic D, Kleava V, Cindric M, Jarak I, Kostrun S, Karminski-Zamola G, Markovic VG, Hranjec M, Brajsa K. (2017) Comparison of Antitumor Activity of Some Benzothiophene and Thienothiophene Carboxanilides and Quinolones in 2D and 3D Cell Culture System. Croat Chem Acta 90, 413-424. doi: 10.5562/cca3139
24. Teodoro JS, Rolo AP, Jarak I, Palmeira CM, Carvalho RA. (2016) The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: Insight into how bile acids decrease obesity. NMR Biomed 29, 1391-1402. doi: 10.1002/nbm.3583.
23. Viegas I, Jarak I, Rito J, Carvalho RA, Metón I, Pardal MA, Baanante IV, Jones JG. (2016) Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.), J Lipid Res 57, 1264-1272. doi: 10.1194/jlr.M067850.
22. Carrola J, Bastos V, Jarak I, Oliveira-Silva R, Malheiro E, Daniel-da-Silva AL, Oliveira H, Santos C, Gil AM, Duarte IF. (2016) Metabolomics of silver nanoparticles toxicity in HaCaT cells: Structure-activity relationships and role of ionic silver and oxidative stress, Nanotoxicology 10, 1105-1117. doi: 10.1080/17435390.2016.1177744.
21. Marçal R, Carrola C, Jarak I, Corvo ML, Duarte IF, ML Pereira. (2016) Microscopic studies of liver and kidney in mice exposed to silver nanoparticles. Microsc Microanal 22, 18-19. doi: https://doi.org/10.1017/S1431927616000283.
20. Burgeiro A, Fuhrmann A, Cherian S, Espinoza D, Jarak I, Carvalho R, Loureiro M, Patrício M, Antunes M, Carvalho E. (2016) Glucose uptake and Lipid metabolism are impaired in epicardial adipose tissue from heart failure patients, with or without diabetes. Am J Physiol Endocrinol Metab 310, E550-564. doi: 10.1152/ajpendo.00384.2015.
19. Alves MG, Martins AD, Jarak I, Barros A, Silva J, Sousa M, Oliveira PF. (2016) Testicular lactate content is compromised in men with Klinefelter syndrome. Mol Reprod Dev 83, 208-216. doi: 10.1002/mrd.22608.
18. Lemos C, Rial D, Gonçalves FQ, Pires J, Silva HB, Silva AC, Marques JM, Rodrigues RJ, Jarak I, Prediger RD, Reis F, Carvalho RA, Pereira FC, Cunha RA. (2016) High sucrose consumption induces cognitive disruption in rats associated with electrophysiological modifications but not with metabolic changes in the hyppocampus. Neuroscience 315, 196-205. doi: 10.1016/j.neuroscience.2015.12.018.
17. Berger ML, Maciejewska D, Vanden Eynde JJ, Mottamal M, Żabiński J, Kaźmierczak P, Rezler M, Jarak I, Piantanida I, Karminski-Zamola G, Mayence A, Rebernik P, Kumar A, Ismail MA, Boykin DW, Huang TL. (2015) Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors, Bioorg Med Chem 23, 4489-4500, doi: 10.1016/j.bmc.2015.06.012.
16. Viegas I, Rito J, Jarak I, Leston S, Caballero-Solares A, Metón I, Pardal MA, Baanante IV, Jones JG. (2015) Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.). Br J Nutr 113, 1345-1354. doi: 10.1017/S0007114515000574.
15. Tavares LC, Jarak I, Nogueira FN, Oliveira PJ, Carvalho RA. (2015) Metabolic evaluations of cancer metabolism by NMR-based stable isotope tracer methodologies. Eur J Clin Invest 45 Suppl 1, 37-43, doi: 10.1111/eci.12358.
14. Nunes P, Jarak I, Heerschap A, Jones JG. (2014) Resolving futile glucose cycling and glycogenolytic contributions to plasma glucose levels following a glucose load. Magn Res Med 71, 1368-73. doi: 10.1002/mrm.24789.
13. Martins F, Rito J, Jarak I, Viegas I, Pardal MA, Macedo MP, Jones JG. (2013) Disposition of [U-2H7]glucose into hepatic glycogen in rat and in seabass. Comp Biochem Physiol A Comp Physiol 166, 316-322. doi: 10.1016/j.cbpa.2013.07.002.
12. Viegas I, Rito J, González JD, Jarak I, Carvalho RA, Metón I, Pardal MA, Baanante IV, Jones JG. (2013) Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.). Comp Biochem Physiol A Comp Physiol 166, 399-405. doi: 10.1016/j.cbpa.2013.07.013.
11. Aleksic M, Bertoša B, Nhili R, Uzelac L, Jarak I, Depauw S, David-Cordonnier M, Kralj M, Tomic S, Karminski-Zamola G. (2012) Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA–binding properties, antitumor evaluation and 3D-derived QSAR analysis. J Med Chem 55, 5044-5060. doi: 10.1021/jm300505h.
10. Viegas I, Rito J, Jarak I, Leston S, Carvalho RA, Meton I, Pardal MA, Baanante IV, Jones JG. (2012) Hepatic glycogen synthesis in farmed European seabass (Dicentrarchus labrax L.) is dominated by indirect pathway fluxes. Comp Biochem Physiol A Comp Physiol 163, 22-29. doi: 10.1016/j.cbpa.2012.04.023.
9. Ester K, Supek F, Majsec K, Marjanovic M, Lembo D, Donalisio M, Šmuc T, Jarak I, Karminski-Zamola G, Kralj M. (2012) Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells. Invest New Drugs 30, 450-467. doi: 10.1007/s10637-010-9571-7.
8. Alves TC, Jarak I, Carvalho RA. (2012) NMR methodologies for studying mitochondrial bioenergetics. Methods Mol Biol, Mitochondrial Bioenergetics: Methods and Protocols 810, 281-309. doi: 10.1007/978-1-61779-382-0_18.
7. Viegas I, Mendes V, Leston S, Jarak I, Carvalho RA, Pardal MA, Manadas B, Jones J. (2011) Analysis of glucose metabolism in farmed european sea bass (Dicentrarchus labrax L.) using deuterated water. Comp Biochem Physiol A Comp Physiol 160, 341-347. doi: 10.1016/j.cbpa.2011.06.029.
6. Jarak I, Marjanovic M, Pintanida I, Kralj M, Karminski-Zamola G. (2011) Novel pentamidine derivatives: synthesis, antitumor properties and polynucleotide-binding activities. Eur J Med Chem 46, 2807-2815. doi: 10.1016/j.ejmech.2011.04.001. (IF: 3.36, Q1: drug discovery)
5. Ester K, Hranjec M, Piantanida I, Caleta I, Jarak I, Pavelic K, Kralj M, Karminski-Zamola G. (2009) Novel derivatives of pyridyl-benzo[b]thiophene-2-carboxamides and benzo[b]thieno[2,3-c]naphthyridin-2-ones: minor structural variations provoke major differences of antitumor action mechanisms. J Med Chem 52, 2482-92. doi: 10.1021/jm801573v.
4. Jarak I, Pavlovic G, Karminski-Zamola G. (2007) Synthesis and crystal structure determination of potentially biologically active new substituted anilides of benzo[2,3-b]thiophene series. Structural Chemistry 18, 103-111.
3. Jarak I, Kralj M, Piantanida I, Suman L, Žinic M, Pavelic K, Karminski-Zamola G. (2006) Novel cyano- and amidino-substituted derivatives of thieno[2,3-b]- and thieno[3,2-b]thiophene-2-carboxanilides and thieno[3,2:4,5]thieno- and thieno[2,3:4,5]thieno[2,3-c]quinolones: synthesis, photochemical synthesis, DNA binding, and antitumor evaluation. Bioorg Med Chem 14, 2859-2868.
2. Jarak I, Kralj M, Šuman L, Pavlovic G, Dogan J, Piantanida I, Žinic M, Pavelic K, Karminski-Zamola G. (2005) Novel cyano- and N-isopropylamidino-substituted derivatives of benzo[b]thiophene-2-carboxanilides and benzo[b]thiophene[2,3-c]quinolones: synthesis, photochemical synthesis, crystal structure determination and antitumor evaluation. 2. J Med Chem 48, 2346-2360.
1. Jarak I, Karminski-Zamola G, Pavlovic G, 4-amino-N-isopropylbenzoamidinium chloride ethanol solvate, Acta Crystallogr C (2005) 61, 98-100.