研究成果・活動

1. Suito T, Deng X, Sato S, Nagao K, Ganser C, Uchihashi T, Tsutsumi M, Nemoto T, Hara Y, Tominaga M, Sokabe T*. Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in Drosophila. iScience. 29(4):115209, 2026. *責任著者
   (https://doi.org/10.1016/j.isci.2026.115209)
   生理研プレスリリース (https://www.nips.ac.jp/release/2026/03/post_571.html)
   生理研 のう君NEWS！(https://www.youtube.com/watch?v=GWAFYRlk-4U)
   生命創成探究センタープレスリリース (https://www.excells.orion.ac.jp/news/13622)
   Touch and temperature : how special fats fine-tune our senses | EurekAlert! (https://www.eurekalert.org/news-releases/1121108)

科学新聞　2026年4月17日6面

2. Deng X, Suito T, Tominaga M, Sokabe T*. Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila. Commun. Biol., 8: 765, 2025. *責任著者
   https://doi.org/10.1038/s42003-025-08154-0
   生理研　プレスリリース（https://www.nips.ac.jp/release/2025/05/post_556.html）
   生命創成探究センター　プレスリリース（https://www.excells.orion.ac.jp/news/12058）
   EurekAlert!　英文プレスリリース（https://www.eurekalert.org/news-releases/1085603）
   中日新聞　2025年6月16日朝刊22面 社会（（https://www.chunichi.co.jp/article/1082868））

3. Ohnishi K, Sokabe T*, Miura T, Tominaga M, Ohta A*, Kuhara A*. G protein-coupled receptor-based thermosensation determines temperature acclimatization of Caenorhabditis elegans. Nat. Commun. 15:1660, 2024. *責任著者
   https://doi.org/10.1038/s41467-024-46042-z

生理研　プレスリリース（https://www.nips.ac.jp/nips_research/press/2024/02/_gpcr.html）

生命創成探究センター　プレスリリース（https://www.excells.orion.ac.jp/news/9739）

4. Sato S, Magaji AM, Tominaga M, Sokabe T*. Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs in Drosophila. Front. Mol. Neurosci. 16:1249715, 2023. *責任著者
   https://doi.org/10.3389/fnmol.2023.1249715

生理研　プレスリリース（https://www.nips.ac.jp/nips_research/press/2023/12/_trp_1.html）
生命創成探究センター　プレスリリース（https://www.excells.orion.ac.jp/news/9387）
EurekAlert!　英文プレスリリース（https://www.eurekalert.org/news-releases/1029796）

神戸新聞　2024年3月14日朝刊18面 科学

5. Sokabe T*, Bradshaw HB, Tominaga M, Leishman E, Chandel A, Montell C*. Endocannabinoids produced in photoreceptor cells in response to light activate Drosophila TRP channels. Sci. Signal. 15(755): eabl6179, 2022. *責任著者．表紙採択．AAAS広報誌「シグナリングに載った日本人研究者」に紹介記事掲載
   https://doi.org/10.1126/scisignal.abl6179

生理研　プレスリリース（https://www.nips.ac.jp/nips_research/press/2022/10/post_490.html）
生命創成探究センター　プレスリリース（https://www.excells.orion.ac.jp/news/5897）
EurekAlert!　英文プレスリリース（https://www.eurekalert.org/news-releases/967759）

6. Suito T, Nagao K, Juni N, Hara Y, Sokabe T, Atomi H, Umeda M. Regulation of thermoregulatory behavior by commensal bacteria in Drosophila. Biosci. Biotechnol. Biochem. zbac087, 2022. 2022年BBB論文賞受賞
   https://doi.org/10.1093/bbb/zbac087

7. Feng X, Takayama Y, Ohno N, Kanda H, Dai Y, Sokabe T, Tominaga M. TRPV4 expression and function in Schwann cells during nerve demyelination after sciatic nerve injury. Commun. Biol. 3(1): 716, 2020.
   https://dx.doi.org/10.1038%2Fs42003-020-01444-9

8. Ohnishi K, Saito S, Miura T, Ohta A, Tominaga M, Sokabe T*, Kuhara A*. OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatization. Sci. Rep. 10(1): 18566, 2020. *責任著者
   https://dx.doi.org/10.1038%2Fs41598-020-75302-3

9. Li Q, DeBeaubien NA, Sokabe T, Montell C. Temperature and sweet taste integration in Drosophila. Curr. Biol. 30(11): 2051-2067, 2020.
   https://doi.org/10.1016/j.cub.2020.03.066

10. Liu J*, Sokabe T*, Montell C. A temperature gradient assay to determine thermal preferences of Drosophila larvae. J. Vis. Exp. (136): e57963, 2018. *筆頭著者
    https://app.jove.com/v/57963/a-temperature-gradient-assay-to-determine-thermal-preferences

11. Sokabe T, Chen HC, Luo J, Montell C. A switch in thermal preference in Drosophila larvae depends on multiple rhodopsins. Cell Rep. 17(2): p336-44, 2016.
    https://dx.doi.org/10.1016%2Fj.celrep.2016.09.028

12. Akitake B, Ren Q, Boiko N, Ni J, Sokabe T, Stockand JD, Eaton BA, Montell C. Coordination and fine motor control depend on Drosophila TRPγ. Nat. Commun. 6:7288, 2015.
    https://dx.doi.org/10.1038%2Fncomms8288

13. Yoshiyama M, Mochizuki T, Nakagomi H, Miyamoto T, Kira S, Mizumachi R, Sokabe T, Takayama Y, Tominaga M, Takeda M. Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle. Am. J. Physiol. Renal. Physiol. 308(10): F1128-34, 2015.
    https://doi.org/10.1152/ajprenal.00016.2015

14. Mizuno H, Suzuki Y, Watanabe M, Sokabe T, Yamamoto T, Hattori R, Gotoh M, Tominaga M. Potential role of transient receptor potential (TRP) channels in bladder cancer cells. J. Physiol. Sci. 64(4): 305–14, 2014.
    https://doi.org/10.1007/s12576-014-0319-6

15. Sato A*, Sokabe T*, Kashio M, Yasukochi Y, Tominaga M, Shiomi K. Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm, Bombyx mori. Proc. Natl. Acad. Sci. USA. 111(13): E1249-55, 2014. *筆頭著者.
    https://doi.org/10.1073/pnas.1322134111

16. Fujita F, Uchida K, Takaishi M, Sokabe T, Tominaga M. Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5-bisphosphate. J. Neurosci. 33(14): 6154-9, 2013.
    https://doi.org/10.1523/jneurosci.5672-12.2013

17. Stefan CP, Zhang N, Sokabe T, Rivetta A, Slayman CL, Montell C, Cunningham KW. Activation of an essential calcium signaling pathway in S. cerevisiae by Kch1 and Kch2, putative low-affinity potassium transporters. Eukaryot. Cell. 12(2): 204-14, 2012.
    https://doi.org/10.1128/ec.00299-12

18. Kashio M, Sokabe T, Shintaku K, Uematsu T, Fukuta N, Kobayashi N, Mori Y, Tominaga M. Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. Proc. Natl. Acad. Sci. USA. 109(17): 6745-50, 2012.
    https://doi.org/10.1073/pnas.1114193109

19. Kida N*, Sokabe T*, Kashio M, Haruna K, Mizuno Y, Suga Y, Nishikawa K, Kanamaru A, Hongo M, Oba A, Tominaga M. Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes. Pflugers Arch. – Eur. J. Physiol. 463(5): 715–25, 2012. *筆頭著者
    https://doi.org/10.1007/s00424-012-1081-3

20. Kohno K*, Sokabe T*, Tominaga M, Kadowaki T. Honey Bee thermal/chemical sensor, AmHsTRPA, reveals neofunctionalization and loss of transient receptor potential channel genes. J. Neurosci. 30(37): 12219-29, 2010. *筆頭著者. 表紙採択.
    https://doi.org/10.1523/jneurosci.2001-10.2010

21. Sokabe T*, Fukumi-Tominaga T, Yonemura S, Mizuno A, Tominaga M*. The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J. Biol. Chem. 285(24): 18749-58, 2010. *責任著者. 表紙採択. Paper of the Weekに選出.
    https://doi.org/10.1074/jbc.m110.103606

22. Kawaguchi H, Yamanaka A, Uchida K, Shibasaki K, Sokabe T, Maruyama Y, Yanagawa Y, Murakami S, Tominaga M. Activation of Polycystic Kidney Disease-2-like 1 (PKD2L1)-PKD1L3 Complex by Acid in Mouse Taste Cells. J. Biol. Chem. 285(23): 17277-81, 2010.
    https://doi.org/10.1074/jbc.c110.132944

23. Shigematsu H, Sokabe T, Danev R, Tominaga M, Nagayama K. A 3.5-nm structure of rat TRPV4 cation channel revealed by zernike phase-contrast cryo-EM. J. Biol. Chem. 285(15): 11210-18, 2010.
    https://doi.org/10.1074/jbc.m109.090712

24. Matsuura H, Sokabe T, Kohno K, Tominaga M, Kadowaki T. Evolutionary conservation and changes in insect TRP channels. BMC Evol. Biol. 9(1): 228, 2009.
    https://doi.org/10.1186/1471-2148-9-228

25. Mandadi S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, Patapoutian A, Fukumi-Tominaga T, Mizumura K, Tominaga M. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch. – Eur. J. Physiol. 458(6): 1093-102, 2009
    https://doi.org/10.1007/s00424-009-0703-x

26. Mochizuki T, Sokabe T*, Araki I, Fujishita K, Shibasaki K, Uchida K, Naruse K, Koizumi S, Takeda M, Tominaga M*. The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures. J. Biol. Chem. 284(32): 21257-64, 2009. *責任著者. F1000 の“Must read” paperに選出.
    https://doi.org/10.1074/jbc.m109.020206

27. Obi S, Yamamoto K, Shimizu N, Kumagaya S, Masumura T, Sokabe T, Asahara T, Ando J. Fluid shear stress induces arterial differentiation of endothelial progenitor cells. J. Appl. Physiol. 106(1): 203-11, 2009.
    https://doi.org/10.1152/japplphysiol.00197.2008

28. Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M, Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J. Clin. Invest. 118(12): 4049-57, 2008.
    https://doi.org/10.1172/jci35957

29. Sokabe T, Tsujiuchi S, Kadowaki T, Tominaga M. Drosophila Painless is a Ca2+-requiring channel activated by noxious heat. J. Neurosci. 28(40): 9929-38, 2008.
    https://doi.org/10.1523/jneurosci.2757-08.2008

30. Denda M, Sokabe T, Fukumi-Tominaga T, Tominaga M. Effects of Skin surface temperature on epidermal permeability barrier homeostasis. J. Invest. Dermatol. 127(3): 654-9, 2007.
    https://doi.org/10.1038/sj.jid.5700590

31. Nakatsuka H*, Sokabe T*, Yamamoto K, Sato Y, Hatakeyama K, Kamiya A, Ando J. Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription. Am. J. Physiol. Gastrointest. Liver Physiol. 291(1): G26-34, 2006. *筆頭著者.
    https://doi.org/10.1152/ajpgi.00467.2005

32. Yamamoto K*, Sokabe T*, Matsumoto T, Yoshimura K, Shibata M, Ohura N, Fukuda T, Sato T, Sekine K, Kato S, Isshiki M, Fujita T, Kobayashi M, Kawamura K, Masuda H, Kamiya A, Ando J. Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat. Med. 12(1): 133-7, 2006. *筆頭著者. “News and Views”でレビューに選出.
    https://doi.org/10.1038/nm1338

33. Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JK, Obi S, Ohura N, Matsushita A, Kamiya A, Ando J. Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am. J. Physiol. Heart Circ. Physiol. 288(4): 1915-24, 2005.
    https://doi.org/10.1152/ajpheart.00956.2004

34. Sokabe T, Yamamoto K, Ohura N, Nakatsuka H, Qin K, Obi S, Kamiya A, Ando J. Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 287(5): 2027-34, 2004.
    https://doi.org/10.1152/ajpheart.00260.2004

35. Ohura N, Yamamoto K, Ichioka S, Sokabe T, Nakatsuka H, Baba A, Shibata M, Nakatsuka T, Harii K, Wada Y, Kohro T, Kodama T, Ando J. Global analysis of shear stress-responsive genes in vascular endothelial cells. J. Atheroscler. Thromb. 10(5): 304-13, 2003.
    https://doi.org/10.5551/jat.10.304

36. Yamamoto K, Sokabe T, Ohura N, Nakatsuka H, Kamiya A, Ando J. Endogenously released ATP mediates shear-stress-induced Ca2+ influx into pulmonary endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 285(2): 793-803, 2003.
    https://doi.org/10.1152/ajpheart.01155.2002

37. Yamamoto K, Takahashi T, Asahara T, Ohura N, Sokabe T, Kamiya A, Ando J. Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J. Appl. Physiol. 95(5): pp2081-8, 2003.
    https://doi.org/10.1152/japplphysiol.00232.2003

38. Korenaga R, Yamamoto K, Ohura N, Sokabe T, Kamiya A, Ando J. Sp1-mediated downregulation of P2X4 receptor gene transcription in endothelial cells exposed to shear stress. Am. J. Physiol. Heart Circ. Physiol. 280(5): pp2214-21, 2001.
    https://doi.org/10.1152/ajpheart.2001.280.5.h2214

1. Ohnishi K, Sokabe T*. Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals. Bioessays. e202400233,2024. *責任著者
   https://doi.org/10.1002/bies.202400233

2. Sokabe T*, Huang J*, Lee Y*. Editorial: Molecular and Cellular Mechanisms of Sensory Functions in Insect Models, volume II. Front. Mol. Neurosci. (Frontiers), 17:443041, 2024. *責任著者
   https://doi.org/10.3389/fnmol.2024.1443041

3. Sokabe T*, Lee Y*, Huang J*. Editorial: Molecular and Cellular Mechanisms of Sensory Functions in Insect Models. Front. Mol. Neurosci (Frontiers), 15:1064452, 2022. *責任著者
   https://doi.org/10.3389/fnmol.2022.1064452

4. Sokabe T, Tominaga M. The TRPV4 cation channel: A molecule linking skin temperature and barrier function. Commun. integr. Biol. 3(6): 619-21, 2010.
   https://doi.org/10.4161/cib.3.6.13461

5. Sokabe T, Tominaga M. A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies. Commun. integr. Biol. 2(2): 170-3, 2009.
   https://doi.org/10.4161/cib.7708

1. 佐藤翔馬, 曽我部隆彰. 感覚受容体を標的とする昆虫忌避剤の作用機序. バイオインダストリー（シーエムシー出版）, 42(11): 1-8, 2025.
   https://www.cmcbooks.co.jp/user_data/bio_nendobetsu.php

2. 佐藤翔馬, 曽我部隆彰. TRP チャネルを標的とした昆虫忌避剤の可能性. 昆虫と自然（ニューサイエンス社）, 59(13): 34-37, 2024
   https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202402224440714901

3. 曽我部隆彰*. ロドプシン-脂質-TRPチャネル情報伝達経路の感覚機能における多機能性. 「膜」（日本膜学会）, 49(2)（2024年3月刊行予定）.

4. 曽我部隆彰*. ＜TRPチャネル以外の温度受容体＞ ショウジョウバエから見つかってきた新たな温度受容メカニズム. (特集 温度・機械刺激受容の最前線) 生物の科学 遺伝（㈱エヌ・ティー・エス）, 78(2): 112-117, 2024 *責任著者
   http://www.nts-book.co.jp/item/detail/summary/bio/20051225_42.htm

5. 水藤拓人, 曽我部隆彰. ショウジョウバエの温度選好性を決める温度受容体と制御因子の解析. 昆虫と自然（ニューサイエンス社）, 57(2): 29-32, 2022
   https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202202221749088476

6. 富永真琴*, 曽我部隆彰*. TRPチャネルによる昆虫の温度センシング. 昆虫と自然（ニューサイエンス社）, 54(11): 30-33, 2019 *責任著者
   https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201902276005306755

7. 曽我部隆彰. 昆虫のTRPチャネルと感覚機能 「TRPチャネルのすべて」.医学のあゆみ（医歯薬出版株式会社）, 270(10): 989-97, 2019
   http://www.pieronline.jp/content/article/0039-2359/270100/989

8. 木田尚子, 曽我部隆彰, 加塩麻紀子, 須賀康, 金丸晶子, 大場愛, 富永真琴. 表皮バリア機能におけるTransient Receptor PotentialVanilloid 4 (TRPV4) の重要性. 日本化粧品技術者会誌（日本化粧品技術者会）, 47(2): 108-18, 2013. 2013-2014年日本化粧品技術者会(SCCJ)学会誌最優秀論文賞受賞
   https://doi.org/10.5107/sccj.47.108

9. 曽我部隆彰. 「しっとり肌」を保つタンパク質を発見！ 月刊「化学」（㈱化学同人）, 65(7): 75, 2010.

10. 曽我部隆彰, 富永真琴. 膀胱伸展を感知するTRPV4チャネル. 医学のあゆみ（医歯薬出版株式会社）, 233(6): 497, 2010.
    https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002233771869219

11. 曽我部隆彰, 富永真琴. 哺乳類における温度受容の分子機構 (Molecular Mechanisms Underlying Thermosensation in Mammals). BRAIN and NERVE（医学書院）, 61(7): 867-73, 2009.
    https://doi.org/10.11477/mf.1416100529

12. 曽我部隆彰, 富永真琴. 細胞感覚とセルセンサー 04細胞膜温度センサー 温度を感じる分子たち. バイオニクス（オーム社）, Vol.4/No.26, p44-50, 2007.
    https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902213586200491

13. 安藤譲二, 曽我部隆彰, 山本希美子. 動脈硬化の病態基盤 9. ヘモダイナミクスと動脈硬化. 循環器科（科学評論社）, 59(Suppl.3): pp121-29, 2006.
    https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902214416071162

14. 安藤譲二, 大浦紀彦, 曽我部隆彰, 山本希美子. ずり応力による遺伝子転写機能調節. 血管医学（Vascular Biology & Medicine）（メディカルレビュー社）, 6(1): pp47-55, 2005.

1. 曽我部隆彰, 「3.6章 温度受容や刺激受容を生み出すしくみ」, 神崎亮平(監), 光野秀文, 櫻井健志, 祐川侑司, 並木重宏(編), 昆虫工学 - 新しい価値を創造する「昆虫の知能」の解明と応用 - (コロナ社), ISBN：978-4-339-06766-8, 2026.
   https://www.coronasha.co.jp/np/isbn/9784339067668/

2. 曽我部隆彰, 「TRPチャネル以外の温度感受性分子」「昆虫の温度受容」「蚊は体温の暖かさを求めて寄ってくる」, 富永 真琴・加塩 麻紀子・関 原明・永島 計・山口 良文(編), 生き物と温度の事典 (朝倉書店), ISBN：978-4-254-17200-3 C3545¸2025.
   https://www.asakura.co.jp/detail.php?book_code=17200

3. Sokabe T*. 3.04 - Insect TRP Channels and Receptors in Physical and Chemical Sensation. In: Astha Mahajan (eds) Neurobiology/Nervous System, Comprehensive Molecular Insect Science, 2nd Edition (Elsevier, Amsterdam, Netherlands), 3: 126-167, 2026. *責任著者
   https://doi.org/10.1016/B978-0-323-95424-2.00013-3

4. Suito T, Nagao K, Kai M, Juni N, Sokabe T, Umeda M. Measurement of Thermoregulatory Behavior in Drosophila melanogaster. In: Yamamoto, D. (eds) Behavioral Neurogenetics, Neuromethods (Humana, New York, NY.), vol 181: pp 77–91, 2022.
   https://doi.org/10.1007/978-1-0716-2321-3_6

1. 江崎誠治, 奥村哲, 鯉淵典之, 佐藤麻紀, 椎橋実智男, 曽我部隆彰, 中島昭, 南沢享. 生理学エデュケーター認定制度の１０年を振り返る. 日本生理学雑誌（日本生理学会）, Vol.86, No.4: 75-86, 2024.

2. 曽我部隆彰, Craig Montell. 光に反応して視細胞で産生される内在性カンナビノイドがショウジョウバエ(Drosophila)のTRPチャネルを活性化する. シグナリングに載った日本人研究者（㈱アスカコーポレーション/Science Japan Office）, p22-23, 2023

3. 曽我部隆彰. A FAOPS2019 satellite – NIPS/Thermal Biology Training Course活動報告. 日本生理学雑誌（日本生理学会）, Vol.81, No.3: p60-64, 2019.

1. Associate Editor in Methods and Model Organisms section, Frontiers in Molecular Neuroscience, 2025.0420~

2. Guest Editor: Takaaki Sokabe, Shoma Sato, Kenichi Ishii. Methods Collection “Current Tools for Sensory-Driven Insect Behavior: Locomotion, Cognition, and Sociality”, J. Vis. Exp., June 2025~
   https://app.jove.com/methods-collections/3990/current-tools-for-sensory-driven-insect-behavior-locomotion-cognition-and-sociality

3. Guest Associated Editor: Takaaki Sokabe, Youngseok Lee, Jia Huang. “Molecular and Cellular Mechanisms of Sensory Functions in Insect Models” in Methods and Model Organisms section, Frontiers in Molecular Neuroscience, July 2021~Oct 2022.
   https://www.frontiersin.org/research-topics/24102/molecular-and-cellular-mechanisms-of-sensory-functions-in-insect-models

4. Guest Associated Editor: Takaaki Sokabe, Youngseok Lee, Jia Huang. “Molecular and Cellular Mechanisms of Sensory Functions in Insect Models - Volume II” in Methods and Model Organisms section, Frontiers in Molecular Neuroscience, Dec 2022~
   https://www.frontiersin.org/research-topics/51196/molecular-and-cellular-mechanisms-of-sensory-functions-in-insect-models---volume-ii

1. 2026年度第2回温度生物研究会, 企画・運営（静岡県立大学）, 2026年8月27‐28日

温度生物研究会 Thermal Biology Forum 

2. The 1st Multisensory Biosystems International Conference, 企画・運営（大阪大学中之島センター）, 2026年5月27‐29日

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