Neurobiology Group

Publication from NIMHANS (February 2023 to till date)

1. Subashchandrabose Chinnathambi* and Rashmi Das. Microglial chemotaxis is facilitated by Tau-induced actin remodeling and P2Y12R-mediated podosome formation. Cell & Bioscience, 2023, IF: 10.02

2. Mahima Kapoor and Subashchandrabose Chinnathambi*. TGF-β1 signalling in Alzheimer’s pathology cytoskeletal reorganization: A specialized Tau perspective. Journal of Neuroinflammation, 2023. IF: 9.96.

3. Subashchandrabose Chinnathambi*, Rashmi Das and Smita Eknath Desale. Tau aggregates induced microglial podosome and filopodial formation in microglia. Molecular Cellular Research, 2023. IF: 5.29.

4. Subashchandrabose Chinnathambi* and Nalini Vijay Gorantla. How the secondary metabolites modulates Tau aggregation in neuronal cells.  Cellular Molecular Neurobiology, 2023, IF: 5.05.

5. Dubey Tushar, Shweta Kishor Sonawane, Mannava MKC, Nangia AK, Madhura Chandrashekar and Subashchandrabose Chinnathambi *. The Curcumin-Artemisinin co-amorphous inhibits Tau aggregation and rescues Tau toxicity. Colloids Surf B Biointerfaces, 2023 Oct 26;221:112970, IF: 6.16.

6. Tushar Dubey, Preeti Kushwaha, H. V. Thulasiram, Madhura Chandrashekar, Subashchandrabose Chinnathambi*. Tau aggregation and Tau toxicity modulated by Ayurvedic extract of Brahmi. International Journal of Biological Macromolecules, 2023. IF: 8.05.

7. Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. Interaction of Tau with G-protein Coupled Purinergic P2Y12 receptor by Molecular Docking and Molecular Dynamic Simulation. Tau Protein. 2nd Edition, Methods in Molecular Biology, Humana Press, New York, NY, 2023.

8. Smita Eknath Desale, Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. Biochemical and biophysical characterization of Tau and α-linolenic acid vesicles in in vitro. Tau Protein, pp. 21-31. Methods in Molecular Biology, Humana Press, New York, NY, 2023.

9. Hariharakrishnan Chidambaram, Smita Eknath Desale, and Subashchandrabose Chinnathambi*. Purinergic receptor P2Y12- mediated Tau internalization in microglia. Tau Protein. Methods in Molecular Biology, Humana Press, New York, NY, 2023.

10. Smita Eknath Desale, Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. α-Linolenic acid induces microglial activation and extracellular Tau internalization. Tau Protein, pp. 21-31. Methods in Molecular Biology, Humana Press, New York, NY, 2023. 

Publication from CSIR-National Chemical Laboratory (July 2013 to January 2023)

11. Hariharakrishnan Chidambaram And Rashmi Das and Subashchandrabose Chinnathambi*, G-Protein coupled Purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodelling in microglia, European Journal of Cell Biology., , (2022).

12. Tazeen Qureshi and Subashchandrabose Chinnathambi*. , Histone Deacetylase-6 modulates Tau Function in Alzheimer’s Disease, Preparation., , (2022).

13. Abhishek A Balmik and Subashchandrabose Chinnathambi*., Inter-relationship of Histone Deacetylase-6 with cytoskeletal organization and remodeling, European Journal of Cell Biology., , (2022).

14. Tushar Dubey #, Shweta Sonawane#, M K Chaitanya Mannava And AshwiniKumar Nangia and Subashchandrabose Chinnathambi*, Curcumin-Pyrogallol and their cocrystal restore nuclear transport and reduce Tau phosphorylation in Alzheimer’s disease, Under Revision., , (2022).

15. Shweta K Sonawane And Tushar Dubey and Subashchandrabose Chinnathambi*. , Tau and Alzheimer’s disease, Royal Chemical Society, Drug Discovery., , (2022).

16. Rashmi Das&, Abhishek A Balmik& And Shweta K Sonawane and Subashchandrabose Chinnathambi*. , Soluble aggregation species of A? and Tau and their role in Alzheimer’s disease, Royal Chemical Society, Drug Discovery., , (2022).

17. Shweta Kishor Sonawane1, 2, Anshu Raina3, Amitabha Majumdar3 Subashchandrabose Chinnathambi 1, 2 And *, EGCG modulates nuclear formaldehyde-induced Tau phosphorylation in Neuronal cells, Under Review., , (2022).

18. Tushar Dubey 1, 5, H. V. Thulasiram6, 7, Subashchandrabose Chinnathambi 1, 7 And *, Bacopa monnieri modulate Tau phosphorylation and impaired nuclear transport, Under Revision., , (2022).

19. Tushar Dubey, Preeti Kushwaha, H. V. Thulasiram, Anshu Raina, Amitabha Majumdar And Subashchandrabose Chinnathambi*. , Tau aggregation and Tau toxicity modulated by Ayurvedic extract of Brahmi, Under Review., , (2022).

20. Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*. , Dual modifications of Tau do not enhance aggregation, Under Review., , (2022).

21. 18. Pramod G. Nagaraju, P Sindhu, Tushar Dubey, Subashchandrabose Chinnathambi, Pooja J Rao And Poornima Priyadarshini C G*. , Influence of protein, polysaccharide and Maillard conjugate on the stability, in vitro release, anti-oxidant property and cell viability of eugenol-olive oil nanoemulsions, International Journal of Biological Macromolecules., , (2021).

22. 17. Subashchandrabose Chinnathambi* and Nalini Vijay Gorantla. , Implications of Valosin-containing protein in promoting autophagy to prevent Tau aggregation in Alzheimer’s disease, Neuroscience., , (2021).

23. Sonawane SK And Uversky VN and Subashchandrabose Chinnathambi*. , Baicalein inhibits heparin-induced Tau aggregation by initializing Tau oligomer formation in vitro, Cell Communication & Signaling., , (2021).

24. Rashmi Das and Subashchandrabose Chinnathambi*. , Microglial remodeling of actin network by Tau oligomers, via G protein- coupled Purinergic receptor, P2Y12R-driven chemotaxis, Traffic., Feb 2021, (2021), DOI:https://doi.org/10.1111/tra.12784.

25. Smita Eknath Desale And Subashchandrabose Chinnathambi*. , ?-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia, Biomolecular Medicine., (2021) 2:4, (2021), DOI:https://doi.org/10.1186/s43556-021-00028-1.

26. Smita Eknath Desale And Subashchandrabose Chinnathambi*., Alpha-Linoleanic acid modulates phagocytosis of extracellular Tau and induces microglial migration. Dec;15(1):84-100. doi: 10.1080/19336918.2021.1898727, Cell Adhesion & Migration., , (2021), DOI:Revision.

27. Smita Eknath Desale And Subashchandrabose Chinnathambi*, Phosphoinositides Signaling Modulates Microglial Phagocytosis in Alzheimer’s disease, Cell Communication & Signaling., , (2021), DOI:Press.

28. Abhishek A Balmik and Subashchandrabose Chinnathambi*., Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease, Cell Communication & Signaling., , (2021), DOI:Revision.

29. Tushar Dubey and Subashchandrabose Chinnathambi*. , Photodynamic sensitizers modulate Cytoskeleton structural dynamics in cells, Cytoskeleton., , (2021), DOI:Revision.

30. Smita Eknath Desale#, Hariharakrishnan Chidambaram# And and Subashchandrabose Chinnathambi*, G-protein coupled receptor, PI3K and Rho Signaling pathways regulates the cascades of Tau and Amyloid-? in Alzheimer’s disease, Molecular Biomedicine., , (2021), DOI:Accepted.

31. Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*, Baicalein inhibits heparin-induced Tau aggregation by initializing Tau oligomer formation in vitro, Cell Communication & Signaling., , (2021), DOI:Cell Communication & Signaling.

32. Tushar Dubey And Subashchandrabose Chinnathambi*, Heat Stress Modulates the GSK-3? Levels and Tau Phosphorylation, Under Review., , (2021).

33. Tushar Dubey, Shweta Kishor Sonawane, Benchamin Abraham, MK Chaitanya Mannava, Ashwini K. Nangia And Subashchandrabose Chinnathambi*, The Curcumin-Artemisinin co-amorphous inhibits Tau aggregation and rescues Tau toxicity, Under Review., , (2021), DOI:Review.

34. Tushar Dubey and Subashchandrabose Chinnathambi*., P10 is a New Ray of Hope for Alzheimer’s disease: A Hypothesis, Under Review., , (2021), DOI:Review.

35. Tushar Dubey, Nalini Vijay Gorantla And Subashchandrabose Chinnathambi*, Photo-excited Toluidine Blue disaggregates the Repeat Tau and modulates Cytoskeletal structure in neuronal cells, Under Review., , (2021).

36. Shweta Kishor Sonawane, Nalini Vijay Gorantla, Abha Dangi And Udaya Kiran Marelli* and Subashchandrabose Chinnathambi*. , Polyamines inhibit Tau aggregation in vitro and influence the cell death pathways in neuronal cells, Under Revision., , (2020).

37. Rashmi Das# And Abhishek Ankur Balmik# and Subashchandrabose Chinnathambi*. , Melatonin mediates anti-inflammatory microglial phenotypes and reduces Tau phosphorylation via Nrf2 activation, ASN Neuro., , (2020), DOI:Press.

38. Dubey T, Gorantla NV, Chandrasekhara K T And Subashchandrabose Chinnathambi*. , Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates Cytoskeletal network in neuronal cells, Scientific Reports, Nature Group., Jul 23;10(1):12380, (2020), DOI:doi: 10.1038/s41598-020-69403-2.

39. Abhishek Ankur Balmik, Hariharakrishnan, Abha Dangi And Udayakiran Marelli and Subashchandrabose Chinnathambi*. ,HDAC6 ZnF UBP as the modifier of Tau structure and function, ACS Biochemistry., 2020, (2020), DOI:doi: 10.1021/acs.biochem.0c00585.

40. Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. , Chemokine receptor, CX3CR1 interaction and signalling in neuronal and microglial cells during Tauopathy, Cell & Bioscience., Sep 15;10:109, (2020), DOI:10.1186/s13578-020-00474-4.

41. Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*. , Role of Cysteine in Tau filament formation, Journal of Biomolecular Structure Dynamics., , (2020), DOI:Press.

42. Rashmi Das and Subashchandrabose Chinnathambi*. , Actin-mediated microglial chemotaxis via Purinergic receptor in Alzheimer's disease, Neuroscience., Nov 10;448:, 325 - 336 (2020), DOI:doi: 10.1016/j.neuroscience.2020.09.024. 

43. Shwetha Nanjundaiah, Hariharakrishnan Chidambaram, Madhura Chandrashekar And Subashchandrabose Chinnathambi*,Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease, Cellular and Molecular Neurobiology., , (2020), DOI:10.1007/s10571-020-00883-6.

44. COVER PAGE: Gorantla Nalini, Sunny Lisni, Rajasekhar Kolla, Nagaraju, Pramod; CG Poornima, Govindaraju Thimmaiah And Subashchandrabose Chinnathambi*., Amyloid-beta-derived Peptidomimetics inhibits Tau aggregation, ACS Omega., , (2020), DOI:Accepted.

45. Madhura Chandrashekar and Subashchandrabose Chinnathambi*., Protein Misfolding and Aggregation in Neurodegenerative Disease, Advances in Bioengineering., , (2020).

46. Nalini Vijay and Subashchandrabose Chinnathambi*., Autophagic pathways to clear the Tau aggregates in Alzheimer’s disease, Cellular and Molecular Neurobiology., , (2020), DOI:10.1007/s10571-020-00897-0.

47. Abha Dangi||, Abhishek Ankur Balmik||, Archana Ghorpade||, Nalini Vijay Gorantla$, Shweta Kishor Sonwane$, Subashchandrabose Chinnathambi* And Udaya Kiran Marelli*, Residue-based propensity of aggregation in Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6, RSC Advances., , (2020), DOI:https://doi.org/10.1039/D0RA03809A.

48. Shweta Kishor Sonawane* and Subashchandrabose Chinnathambi*. , P301L, FTDP-17 mutant exhibits enhanced glycation in vitro, Journal of Alzheimer's Disease., , (2020), DOI:10.3233/JAD-191348.

49. Rashmi Das And Abhishek Ankur Balmik and Subashchandrabose Chinnathambi*. , Phagocytosis of full-length Tau oligomers by Actin-remodeling of Activated Microglia, Journal of Neuroinflammation., , (2020), DOI:doi: 10.1186/s12974-019-1694-y.

50. Shweta Kishor Sonawane, Chidambaram H, Boral D, Gorantla NV, Balmik AA, Dangi A, Ramasamy S, Marelli UK And Subashchandrabose Chinnathambi*., EGCG impedes human Tau aggregation and interacts with Tau, Nature Scientific Reports Accepted., , (2020), DOI:Revision.

51. Gorantla NV, Das R, Chidambaram H, Dubey T, Mulani FA, Thulasiram HV And Subashchandrabose Chinnathambi*. , Basic Limonoid modulates Chaperone-mediated Proteostasis and dissolve Tau fibrils, Scientific Reports, Nature Group., , (2020), DOI:doi: 10.1038/s41598-020-60773-1.

52. Smita Eknath Desale and Subashchandrabose Chinnathambi*, Dietary fatty acids influence microglial phagocytosis to clear the extracellular Tau in Alzheimer’s disease, Journal of Neuroinflammation., , (2020), DOI:Proof.

53. Hariharakrishnan Chidambaram and Subashchandrabose Chinnathambi*, G-Protein Coupled Receptors and Tau-Different roles in Alzheimer’s disease, Neuroscience., , (2020), DOI:Accepted, NSC-19-1683.

54. Abhishek Balmik@ And Shweta Sonawane@ and Subashchandrabose Chinnathambi*, Modulation of Actin network and Tau phosphorylation by HDAC6 ZnF UBP domain, BioRXiV and Cellular and Molecular Neurobiology., , (2020), DOI:doi: https://doi.org/10.1101/702571, CEMN-D-20-00055R1.

55. Nalini Vijay Gorantla And Ekambaram Balaraman and Subashchandrabose Chinnathambi*., Cobalt-based metal complexes prevent the aggregation of Repeat Tau in Alzheimer’s disease, International Journal of Biological Macromolecules., , (2020), DOI:doi: 10.1016/j.ijbiomac.2020.02.278.

56. Abhishek A Balmik, Rashmi Das, Abha Dangi, Udaya Kiran Marelli And Subashchandrabose Chinnathambi*., Melatonin Interacts with Repeat Domain of Tau to Mediate Disaggregation of Paired Helical Filaments, BBA, General Subjects., 1864 (3), 129467 (2020), DOI:doi: 10.1016/j.bbagen.2019.129467.

57. Rashmi Das# And Abhishek Ankur Balmik# and Subashchandrabose Chinnathambi*, Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology, International Journal of Biological Macromolecules., , (2020), DOI:doi: 10.1016/j.ijbiomac.2020.01.296.

58. ShwetaKishor Sonawane and Subashchandrabose Chinnathambi*. , A green tea polyphenol Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network, Under Review., , (2019).

59. Nalini Vijay Gorantla, Rashmi Das And Ekambaram Balaraman* and Subashchandrabose Chinnathambi*, Transition metal nickel prevents Tau aggregation in Alzheimer’s disease, International Journal of Biological Macromolecules., , (2019), DOI:doi: 10.1016/j.ijbiomac.2019.11.176.

60. Shweta Sonawane#, Abhishek Balmik#, Debjyoti Boral And Sureshkumar Ramasamy and Subashchandrabose Chinnathambi*, Baicalein suppresses Tau fibrillization by sequestering oligomers, Archives of Biochemistry and Biophysics, Review and Published in BioRxiv doi: https://doi.org/10.1101/704536., 675, 108119 (2019), DOI:https://doi.org/10.1016/j.abb.2019.108119; BioRxiv doi: https://doi.org/10.1101/704536.

61. Tushar Dubey and Subashchandrabose Chinnathambi*. , Brahmi (Bacopa monnieri): An Ayurvedic herb against the Alzheimer’s disease, Archives of Biochemistry and Biophysics, review., , (2019), DOI:doi: 10.1016/j.abb.2019.108153.

62. COVER PAGE: Tushar Dubey, Nalini Vijay Gorantla, Kagepura Thammaiah Chandrashekara And Subashchandrabose Chinnathambi*., Photo-excited Toluidine blue inhibits Tau aggregation in Alzheimers disease, ACS Omega., 4 (20), 18793 - 18802 (2019), DOI:DOI 10.1021/acsomega.9b02792.

63. COVER PAGE: Rashmi Das and Subashchandrabose Chinnathambi*. , Microglial Priming of Antigen Presentation and Adaptive Stimulation in Alzheimer’s disease, Cellular and Molecular Life Sciences., doi: 10.1007/s00018-019-03132-2, (2019), DOI:https://doi.org/10.1007/s00018-019-03132-2 (2019).

64. Shweta Sonawane and Subashchandrabose Chinnathambi*, Protein Capped Metal Nanoparticles Inhibit Tau Aggregation in vitro, ACS Omega, Chem RXiV, https://doi.org/10.26434/chemrxiv.8208026.v1., 7, 12833 - 12840 (2019).

65. Nalini Vijay Gorantla, Vinod Ganesh Landge, Pramod G Nagaraju, Poornima Priyadarshini, Balaraman Ekambaram* And Subashchandrabose Chinnathambi*, Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer’s Disease, ACS Omega, BioRxIV (doi.org/10.1101/363572)., , (2019), DOI:doi.org/10.1021/acsomega.9b00692.

66. Nalini V. Gorantla, Rashmi Das, Fayaj A. Mulani And Hirekodathakallu V. Thulasiram* and Subashchandrabose Chinnathambi*, Neem derivatives inhibits Tau aggregation, Journal of Alzheimer's Disease Reports., 3, 169 - 178 (2019), DOI:DOI 10.3233/ADR-190118.

67. Nalini Vijay Gorantla and Subashchandrabose Chinnathambi*., Tau Protein Squired by Molecular Chaperones during Alzheimer’s Disease, Journal of Molecular Neuroscience (Springer)., 2018 Nov;66(3), 356 - 368 (2018).

68. Shweta Kishor Sonawane and Subashchandrabose Chinnathambi*., Prion-like Propagation of Post-translationally Modified Tau in Alzheimer’s Disease, Journal of molecular Neuroscience, Springer., , 1 - 11 (2018), DOI:10.1007/s12031-018-1111-5.

69. Abhishek Balmik and Subashchandrabose Chinnathambi*, Multi-faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer`s Disease, Journal of Alzheimer's Disease (JAD))., 2018;62(4):1481-1493, (2018).

70. Nalini Vijay Gorantla, Puneet Kandelwal And Pankaj Poddar and Subashchandrabose Chinnathambi*., Microtubule-Associated Protein-Tau Conformation Mapped by Raman Spectroscopy, Methods in Molecular Biology (MiMB- Tau Protein) Springer Publications., , (2017).

71. Nalini Vijay Gorantla, Alexander V. Shkumatov And and Subashchandrabose Chinnathambi*., Conformational Dynamics of Intracellular Tau Revealed by Circular Dichorism and SAXS, Methods in Molecular Biology (MiMB- Tau Protein) Springer Publications., , (2017).

72. Batkulwar KB, Bansode SB, Patil GV, Godbole RK, Kazi RS, Chinnathambi Subashchandrabose, Shanmugam D And Kulkarni MJ, Investigation of Phosphoproteome in RAGE signaling, Proteomics., October, (2015), DOI:10.1002/pmic.201400169.

73. Coppola*, Chinnathambi Subashchandrabose*, et al. And , Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer’s disease, (First Author) - Human Molecular Genetics (HMG)., 21(15), 3500 - 3512 (2012), DOI:10.1093/hmg/dds161.

74. Sadasivam J*, Chinnathambi Subashchandrabose*, Mandelkow Eva., and Mandelkow And E, Conformations of Microtubule-Associated Protein Tau mapped by fluorescence resonance energy transfer (FRET), First Author, Book Chapter - Methods in Molecular biology (Amyloid Proteins)., 849, 85 - 99 (2012), DOI:10.1007/978-1-61779-551-0_7.

75. Daebel V, Chinnathambi Subashchandrabose #, Biernat J, Schwalbe M, Habenstein B, Loquet A, Müller H, Baldus M, Griesinger C, Zweckstetter M, Mandelkow E, Vijayan V And Lange A., Beta - Sheet core of tau paired helical filaments revealed by solid-state NMR, Journal of American Chemical Society (JACS)., 134(34), 13982 - 13989 (2012), DOI:10.1021/ja305470p.

76. Shkumatov, A.V*., Chinnathambi Subashchandrabose*., Mandelkow, E., and Svergun And D.I, Structural memory of natively unfolded Tau protein detected by small-angle X-ray scattering (SAXS), First Author, Proteins., 79, 2122 - 2131 (2011), DOI:10.1002/prot.23033.

77. Stefan B , Marco DM , Chinnathambi Subashchandrabose, Jacek B, Christian Griesinger , Eckhard Mandelkow And and Markus Zweckstetter , The Dynamic Structure of Filamentous Tau, Angewandte Chemistry, International Edition., 50, 11520 - 11524 (2011), DOI:10.1002/anie.201105493.

78. Wegmann, S., Jung, Y.J., Chinnathambi Subashchandrabose#., Mandelkow, E.M., Mandelkow, E., and Muller And D.J.,Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability, COVER PAGE ARTICLE - Journal of Biological Chemistry (JBC)., 285, 27302 - 27313 (2010), DOI:10.1074/jbc.M110.145318.

79. Pappachan, A., Chinnathambi Subashchandrabose#, Satheshkumar, P.S., Savithri, H.S., and Murthy And M.R., A single point mutation disrupts the capsid assembly in Sesbania Mosaic Virus resulting in a stable isolated dimer, COVER PAGE ARTICLE - Virology., 392, 215 - 221 (2009), DOI:10.1016/j.virol.2009.06.047.

80. Pappachan, A., Chinnathambi Subashchandrabose#, Satheshkumar, P.S., Savithri, H.S., and Murthy And M.R., Structure of recombinant capsids formed by the beta-annulus deletion mutant rCP (Delta48-59) of Sesbania mosaic virus, COVER PAGE ARTICLE - Virology., 375, 190 - 196 (2008), DOI:10.1016/j.virol.2008.01.023.

81. Jeganathan, S., Hascher, A., Chinnathambi Subashchandrabose, Biernat, J., Mandelkow, E.M., and Mandelkow And E.,Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation, Journal of Biological Chemistry (JBC)., 283, 32066 - 32076 (2008), DOI:10.1074/jbc.M805300200.

82. Tazeen Qureshi and Subashchandrabose Chinnathambi*., Histone Deacetylase-6 modulates Tau Function in Alzheimer’s Disease, Cell Communication & Signaling., , (0000), DOI:Revision