The Major Crimes Division (MCD), or "Major Crimes" as it is generally called, is an elite investigative unit of the Los Santos Police Department which investigates a wide variety of select crimes on a citywide basis which are often high-profile in nature.

D Platoon is the Special Weapons and Tactics team of the LSPD. It provides the Department with 24-hour coverage necessary for immediate response to barricaded suspects, snipers, crisis and hostage negotiations, potential suicide-related situations, and other high-risk incidents. Rapid deployment, surprise attacks, extensive tactics training and thorough planning are all parts of successful SWAT operations. SWAT currently operates the Lenco B.E.A.R. and two smaller Lenco Bearcat vehicles and one armored rescue vehicle.