Preprint（Total: 1）

1. "In vivo monitoring of hyperpolarized [15N]betaine-d11 signal for one hour"
   Ruki Ashikaga†, Yutaro Saito†, Abdelazim Elhelaly, Hiroyuki Yatabe, Yohei Kondo, Hiroshi Nonaka, Imai Hirohiko, Fuminori Hyodo, Masayuki Matsuo, Shinsuke Sando*
   ChemRxiv 2025, DOI: 10.26434/chemrxiv-2025-0qxks
   †These authors contributed equally to this work

Original Paper（Total: 25）

1. "In Vivo Multiplexed Analysis of Aminopeptidase Activities by Hyperpolarized Molecular Probes for Tumor Diagnostic Applications"
   Hiroyuki Yatabe, Keita Saito, Ayumi Koike, Yoichi Takakusagi, Abdelazim E. Elhelaly, Fuminori Hyodo, Masayuki Matsuo, Wataru Mizukami, Maki Sugaya, Tsuyoshi Osawa, Murali C. Krishna, Kazutoshi Yamamoto, Yutaro Saito, Shinsuke Sando*
   J. Am. Chem. Soc. 2026, 148, 9296–9308. DOI: 10.1021/jacs.5c16910
   ChemRxiv 2025, DOI: 10.26434/chemrxiv-2025-wcbc3

2. "Investigation of the physicochemical and functional properties of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated aptamers"
   Seojung Cho, Jumpei Morimoto, Yutaro Saito, Yukiko Nagai, Asuka Sakata, Keitaro Yoshimoto, Mitsuki Tsuruta, Daisuke Miyoshi, Shinsuke Sando*
   Biomater. Sci. 2026, 14, 232–239. DOI: 10.1039/D5BM01078K

3. "Solid-phase synthesis of polyunsaturated fatty acids facilitates precise structural investigation on FFAR1/4 agonist activities and the inhibition of neutrophil pseudopod formation"
   Yaohong Shi,   Yutaro Saito,*   Masashi Hotta, Mayuko Akita, Akiharu Uwamizu, Junken Aoki, Jun Kunisawa, Shinsuke Sando*
   RSC Adv. 2025, 15, 32263–32270. DOI: 10.1039/d5ra04836b

4. "Ala-[1-13C]Gly-d2-15NMe2: Hyperpolarized Molecular Probe for Aminopeptidase N Activity with Suppressed Scalar Relaxation"
   Yutaro Saito,† Hiroyuki Yatabe,† Murali C. Krishna, Kazutoshi Yamamoto, Shinsuke Sando*
   Chem. Lett. 2025, 54, upaf150. DOI: 10.1093/chemle/upaf150
   Selected as Editor's Choice.
   †These authors contributed equally to this work

5. "Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis"
   Yutaro Saito,†,* Mayuko Akita,† Azusa Saika,† Yusuke Sano, Masashi Hotta, Jumpei Morimoto, Akiharu Uwamizu, Junken Aoki, Takahiro Nagatake, Jun Kunisawa,* Shinsuke Sando*
   Nature Chem. 2025, 17, 1391–1400. DOI: 10.1038/s41557-025-01853-5
   ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-p2tcc
   †These authors contributed equally to this work
   [ハイライト]
   ・東大（本部・工学系）プレスリリース
   ・日本経済新聞電子版
   ・毎日新聞電子版
   ・科学新聞（2025/7/4）
   ・サードニュース
   ・日経バイオテク
   ・Science Japan

6. "Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High-resolution Whole-organ 3D Mapping"
   Bo Yi, Hiroyuki Yatabe, Daichi M. Sakamoto, Iori Tamura, Yutaro Saito, Naoki Yamada, Ruki Ashikaga, Masafumi Kuroda, Shimpei I. Kubota, Kazuki Tainaka, Shinsuke Sando*
   Angew. Chem. Int. Ed. 2025, 64, e202504668. DOI: 10.1002/anie.202504668

7. "Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer"
   Seojung Cho, Miyuki Hori, Ryosuke Ueki, Yutaro Saito, Yukiko Nagai, Haruka Iki, Akira Tsuchiya, Tomohiro Konno, Kensuke Owari, Haishun Piao, Kazunobu Futami, Shinsuke Sando
   Biomatr. Sci. 2025, 13, 1347-1353. DOI: 10.1039/D4BM01541J

8. "Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides"
   Yohei Kondo, Yutaro Saito, Tomohiro Seki, Yoichi Takakusagi, Jumpei Morimoto, Hiroshi Nonaka, Koichiro Miyanishi, Wataru Mizukami, Makoto Negoro, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Masayuki Matsuo, Natarajan Raju, Rolf Swenson, Murali C. Krishna, Kazutoshi Yamamoto, and Shinsuke Sando*
   Science Adv. 2024, 10, eadp2533. DOI: 10.1126/sciadv.adp2533
   ChemRxiv 2022, DOI: 10.26434/chemrxiv-2022-tfkk1.
   東京大学工学系プレスリリース
   日本経済新聞電子版

9. "Oxidation-guided and collision-induced linearization assists de novo sequencing of thioether macrocyclic peptides"
   Ayaka Hayashi   Yuki Goto,* Yutaro Saito, Hiroaki Suga, Jumpei Morimoto,* Shinsuke Sando*
   Chem. Commun. 2024, 60, 9436–9439. DOI: 10.1039/D4CC03179B

10. "Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging"
    Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Jumpei Morimoto, Yoichi Takakusagi, Masafumi Kuroda, Shumpei I. Kubota, Hiroyuki Yatabe, Minoru Kobayashi, Hiroshi Harada, Kazuki Tainaka, and Shinsuke Sando*
    Science Adv. 2024, 10, eado8471. DOI: 10.1126/sciadv.ado8471
    ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-sdjss

11. "Pimonidazole-alkyne conjugate for sensitive detection of hypoxia by Cu-catalyzed click reaction"
    Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shinsuke Sando*
    Anal. Sci. 2024, 40, 1061–1070. DOI: 10.1007/s44211-024-00520-y

12. "Whole-body and whole-organ 3D imaging of hypoxia using activatable covalent fluorescent probe compatible with tissue clearing"
    Daichi M. Sakamoto, Iori Tamura, Bo Yi, Sho Hasegawa, Yutaro Saito, Naoki Yamada, Yoichi Takakusagi, Shimpei I. Kubota, Hiroshi Harada, Kenjiro Hanaoka, Masayasu Taki, Masaomi Nangaku, Kazuki Tainaka*, and Shinsuke Sando*
    ACS Nano 2024, 18, 5167–5179. DOI: 10.1021/acsnano.3c12716
    ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-brfdm

13. "Label-free quantification of passive membrane permeability of cyclic peptides across lipid bilayers: Penetration speed of cyclosporin A across lipid bilayers"
    Takahiro Ono, Kazuhito V. Tabata, Yuki Goto, Yutaro Saito, Hiroaki Suga, Hiroyuki Noji, Jumpei Morimoto* and Shinsuke Sando*
    Chem. Sci. 2023, 14, 345–349. DOI: 10.1039/D2SC05785A

14. "Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo"
    Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Nobu Oshima, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna,* Shinsuke Sando*
    Science Adv. 2022, 8, eabj2667. DOI: 10.1126/sciadv.abj2667
    東京大学工学系プレスリリース
    日本経済新聞電子版

15. “Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state"
    Yohei Kondo, Yutaro Saito, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Tatsuya Nishihara, Marino Itoda, Hiroshi Nonaka, Masayuki Matsuo, and Shinsuke Sando
    RSC Adv. 2021, 11, 37011–37018. DOI: 10.1039/D1RA07343E

16.  “Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion"
    Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando, and Kouhei Tsumoto
    Commun. Biol. 2021, 4, 1041. DOI: 10.1038/s42003-021-02575-3

17. “Structural basis for selective inhibitor of human serine hydroxymethyltransferase by secondary bile acid conjugate"
    Tomoki Ota‡, Akinobu Senoo‡, Masumi Shirakawa‡, Hiroshi Nonaka, Yutaro Saito, Sho Ito, Go Ueno, Satoru Nagatoishi, Kouhei Tsumoto, and Shinsuke Sando
    iScience, 2021, 24, 102036. DOI: 10.1016/j.isci. 2021.102036

18. “In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-13C]glycine”
    Georgios Batsios, Chloé Najac, Peng Cao, Pavithra Viswanath, Elavarasan Subramani, Yutaro Saito, Anne Marie Gillespie, Hikari A.I. Yoshihara, Peder Larson, Shinsuke Sando, Sabrina M. Ronen
    Sci. Rep. 2020, 10, 6244. DOI: 10.1038/s41598-020-63160-y

19. “Synthesis of Polybenzoacenes by Annulative Dimerization of Phenylene Triflate through Twofold C‐H Activation”
    Mizuho Uryu, Taito Hiraga, Yoshito Koga, Yutaro Saito, Kei Murakami, and Kenichiro Itami
    Angew. Chem., Int. Ed. 2020, 59, 6551–6554. DOI: 10.1002/anie.202001211

20. “Selective Transformation of Strychnine and 1,2-Disubstituted Benzenes by C–H Borylation”
    Yutaro Saito, Kotono Yamanoue, Yasutomo Segawa, and Kenichiro Itami
    Chem 2020, 6, 985–993. DOI:10.1016/j.chempr.2020.02.004

21. “Design strategy for serin hydroxymethyltransferase probe based on retro-aldol-type reaction”
    Hiroshi Nonaka, Yuki Nakanishi, Satoshi Kuno, Tomoki Ota, Kentaro Mochidome, Yutaro Saito, Fuminori Sugihara, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, and Shinsuke Sando
    Nat. Commun. 2019, 10, 876. DOI: 10.1038/s41467-019-08833-7

22. “Synthesis of partially and fully fused polyaromatics by annulative chlorophenylene dimerization”
    Yoshito Koga, Takeshi Kaneda, Yutaro Saito, Kei Murakami, and Kenichiro Itami
    Science 2018, 359, 435–439. DOI: 10.1126/science.aap9801

23. 
    

24. “Flexible Reaction Pocket on Bulky Diphosphine−Ir Complex Controls Regioselectivity in para-Selective C−H Borylation of Arenes”
    Brandon E. Haines, Yutaro Saito, Yasutomo Segawa, Kenichiro Itami, and Djamaladdin G. Musaev
    ACS Catal. 2016, 6, 7536–7546. DOI: 10.1021/acscatal.6b02317

25. “para-C−H Borylation of Benzene Derivatives by a Bulky Iridium Catalyst”
    Yutaro Saito, Yasutomo Segawa, and Kenichiro Itami
    J. Am. Chem. Soc. 2015, 135, 5193–5198. DOI: 10.1021/jacs.5b02052

Review（Total: 2）

1. "C–H Borylation of Arenes: Steric-controlled Para-selectivity and Application to Molecular Nanocarbons"
   Yasutomo Segawa*, Mai Nagase, Yutaro Saito, Kenta Kato, and Kenichiro Itami*
   J. Synth. Org., Jpn. 2022, 80,994–999. DOI: 10.5059/yukigoseikyokaishi.80.994

2. “(R)- and (S)-2,2’-Bis(3,5-dimethylphenylphosphino)-6,6’-dimethoxy-1,1’-biphenyl”
   Yutaro Saito, Yasutomo Segawa, and Kenichiro Itami
   e-EROS 2017, DOI: 10.1002/047084289X.rn02052