There are two modes to execute 4MRNA.

1. Default mode: For all users.

2. Customize mode: For experts.  If needed, you can edit and customize the code. For example, you can adjust parameters by yourself to get more diverse models, or add models prepared by other methods to perform molecular replacement.

1. Create a new directory on your computer for executing 4MRNA. After creating it, place your reflection file (.mtz) for molecular replacement into that directory.

2. Open Ubuntu/Terminal, change to the directory created in Step 1, and run the command 4MRNA.

3. When prompted to choose the execution mode, select "default".

4. When 4MRNA finishes, a directory named "4MRNA-Results" will be created, containing up to seven candidate solutions for molecular replacement.

1. .Create a new directory on your computer for executing 4MRNA. After creating it, place your reflection file (.mtz) for molecular replacement into that directory.

2. Open Ubuntu/Terminal, change to the directory created in Step 1, and run the command 4MRNA.

3. When prompted to choose the execution mode, select "customize".

4. You can edit each downloaded code.

5. Please run the edited scripts with the bash command on Ubuntu/Terminal in the order indicated by the number at the beginning of each file.

6. When 4MRNA finishes, a directory named "4MRNA-Results" will be created, containing up to seven candidate solutions for molecular replacement.