Embedded Files
1. (2022) Gemma Camara, Majed Alotaibi, Melissa Lessard-Beaudoin, Kate Bush, Rona K Graham. Sex Differences in Cognitive Associated Specific Scent Loss in Seniors
Poster to present at: 89e Congrès de l'Acfas, May 2022
2. (2021) RK Graham. Improvement in olfactory and cognitive function post olfactory therapy in MCI individuals
Invited oral presentation: Smell and Taste Conference, Marburg Germany Nov 2021
3. (2021) Melissa Lessard-Beaudoin, Marco Perez Caceres, Laura M Gonzalez, Tamas Fulop, Dominique Lorrain, Kevin Whittingstall and Rona K. Graham. Investigation des fonctions olfactives et cognitives post-thérapie olfactive chez d’individus atteints de trouble cognitif léger: Résultats préliminaires
Poster presented at: Journee Pivot 2021, Nov 2021
4. (2021) Melissa Lessard-Beaudoin, Marco Perez Caceres, Laura M Gonzalez, Tamas Fulop, Dominique Lorrain, Kevin Whittingstall and Rona K. Graham. Improvement of olfactory and cognitive functions post olfactory therapy in MCI
Poster presented at: LabRoots Neuroscience Virutal Conference, Aug 2021
5. (2021) Gemma Camara, Majed Alotaibi, Melissa Lessard-Beaudoin, Kate Busch, and Rona K Graham. Sex Differences in Cognitive Associated Specific Scent Loss in Seniors. Awarded top presentation by a Master’s student.
Poster presented at: Journee Pivot 2021, Nov 2021
6. (2021) Laura Martínez González, Adam Bourissai, Mélissa Lessard-Beaudoin, Réjean Lebel, Luc Tremblay, Martin Lepage, and Rona K. Graham. Amelioration of some olfactory system deficits with DHA treatment in APOE4 transgenic mice.
Poster presented at: Neurosymposium Conference, McGill, virtual, June 2021
7. (2021) Rona K. Graham, Melissa Lessard-Beaudoin, Marco Perez Caceres, Laura M Gonzalez, Tamas Fulop, Dominique Lorrain and Kevin Whittingstall. Investigation of the impact of olfactory therapy on olfaction and cognition in MCI.
Oral presentation: Cognitive Impairment Conference (virtual), Feb 2021
8. (2021) Laura Martínez González, Adam Bourissai3, Mélissa Lessard-Beaudoin, Réjean Lebel, Luc Tremblay, Martin Lepage, and Rona K. Graham. DHA treatment rescues recognition memory and cortex atrophy in a murine model of MCI
Poster presented at: Journée Phare (Virtual), Université de Sherbrooke, Feb 2021
9. (2021) Majed AlOtaibi M Lessard-Beaudoin, Laura M Gonzales, Raphaël ChouinardWatkins, Melanie Plourde, Frederic Calon and RK Graham. Caspase activation and inflammation observed in the olfactory bulb of APOE4 transgenic mice.
Poster presented at: AAIC, Amsterdam, July 2021
10. (2020) Maryann Nicola, Melissa Lessard-Beaudoin, Laura Martinez Gonzalez, Tamas Fulop and Rona K Graham. Increased awareness of olfactory dysfunction among MCI individuals using the extended olfactory self-report
Oral presentation: 2nd International Conference on Neurology and Neurosurgery, Virtual conference, December 2020
11. (2020) Gemma Camara, Majed Alotaibi, Melissa Lessard-Beaudoin, Kate Busch, and Rona K Graham. The relationship between cognitive scores and detection of specific odours in the elderly.
Poster presented at: Neurodegenerative Diseases: Biology and Therapeutics Conference Virtual conference, December 2020 and feature on Gemma Camara Cold Springs Harbor Laboratory, https://currentexchange.cshl.edu/blog/2020/12/visitor-of-the-week-191
12. Rona K Graham, Mélissa Lessard-Beaudoin, Marco Perez Caceres, Laura M Gonzalez, Amal Loudghi, Tamas Fulop, Dominique Lorrain and Kevin Whittingstall. Odours to the rescue for individuals with MCI: Investigation of the impact of olfactory therapy on olfaction and cognition.
Oral presented at: Global Virtual Conference on Neurodegenerative Diseases Sept 2020
13. (2020) Mélissa Lessard-Beaudoin, Jean-Bernard Denault, and Rona K. Graham Identification of MLH1 as novel caspase-6 and -7 substrates and fragments observed in murine brain.
Poster presented at: Cell Biology LabRoots Virtual Conference, September 2020
14. (2020) Laura Martínez González, Adam Bourissai, Mélissa Lessard-Beaudoin, Réjean Lebel, Luc Tremblay, Martin Lepage, and Rona K. Graham. DHA treatment rescues recognition memory but not atrophy of some olfactory brain regions in a murine model of MCI
Poster presented at: Neurodegenerative Diseases: Biology and Therapeutics Conference Virtual conference, December 2020
15. (2020) FJ Pio, M Lessard-Beaudoin, E Peachey, Devine Calanog, Terri Petkau, G Leonard, MA Pouladi , BR Leavitt and RK Graham. Early olfactory memory deficits in HD and unawareness of olfactory dysfunction
Poster presented at: Huntington Study Group: HD in Focus, Virtual conference, October 2020
16. (2020) Majed AlOtaibi, Mélissa Lessard-Beaudoin, Amel Loudghi, Raphaël Chouinard-Watkins, Melanie Plourde, Frederic Calon , C. Alexandre Castellano, Stephen Cunnane, Pierrette Gaudreau, and Rona K. Graham. Decrease in Olfactory Cortex Volume and Alterations in Caspase Expression in the Olfactory Bulb in the Pathogenesis of Alzheimer’s Disease
Poster presented: AD Association International Conference, Amsterdam, July 2020 (online due to covid)
17. (2020) LM González, M Lessard-Beaudoin and RK. Graham. Atrophie précoce de certaines régions du cerveau chez des souris exprimant un facteur de risque génétique pour la maladie d'Alzheimer - Souris transgéniques APOE4
Poster to present at: Les 88e Congres de l’Association francophone pour le savoir (ACFAS), Quebec (May 2020) (accepted, however conference cancelled due to covid)
18. (2019) LM González, M Lessard-Beaudoin and RK. Graham. Abnormalities in the olfactory system and its modulation as a therapeutic approach in MCI.
Poster presented at: Journee Pharee, 11th Edition, Orford, Quebec (Dec 2019)
19. (2019) Melissa Lessard-Beaudoin, Melissa Laroche, Marta Garcia-Miralles,, Charbel Kreidy, Blair Leavitt, Emma Peachey, Mahmoud Pouladi, and Rona K. Graham. Olfactory neuronal network dysfunction in HD patients and YAC128 mice: Smelling the disease coming.
Poster presented at: 4th Edition Neurosymposium, Montreal, Quebec (June 2019)
20. (2019) RK Graham, M Lessard-Beaudoin, Jolene Ooi, MA Pouladi . Increase in caspases and cleavage of STK3, a caspase substrate and upstream regulator of YAP in a striatal neuronal cell line model of Huntington disease following serum deprivation.
Poster presented at: Gordon Research Conference CAG triplet repeat diseases, Lucca, Italy (June 2019)
21. (2019) LM González, M Lessard-Beaudoin and RK. Graham. Abnormalities in the olfactory system and its modulation as a therapeutic approach in MCI.
Poster presented at: 4th Edition Neurosymposium, Montreal, Quebec (June 2019)
22. (2018) M Lessard-Beaudoin, L Yu-Taeger, M Laroche, E Singer, O Riess, HHP Nguyen and RK Graham. Olfactory bulb atrophy and caspase activation observed early in the BACHD transgenic lines.
Poster presented at: European HD Network Conference, Vienna, Austria (Sept 2018)
23. (2018) Melissa Lessard-Beaudoin, Majed AlOtaibi, Amal Loudghi, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona Graham.
Association between olfactory deficits and subtle cognitive decline: tools for the general physician.
Poster presented at: RQRV conference, Quebec city, Quebec (Oct 2018)
24. (2018) Carolyne-Mary Lowry, Rona Graham, Michel Lebel and J. Richard Wagner. Ascorbate supplementation increases 5-hydroxymethylcytosine in brain cerebellum DNA of ascorbate knockout mice. Role of Vitamin C in TET-mediated oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in the brain of young mice.
Presented at: Conference of Society for Redox Biology and Medicine, Chicago, USA (Nov 2018)
25. (2018) M Lessard-Beaudoin, Jolene Ooi, MA Pouladi and RK Graham. Activation des caspases dans une lignée neuronale striatales modèle de la maladie de Huntington.
Poster presented at: Neurosymposium – 3rd Edition, Montreal, Quebec (June 2018)
26. (2018) M Lessard-Beaudoin, Jolene Ooi, MA Pouladi and RK Graham. Altérations des mécanismes de mort cellulaire dans une lignée neuronale striatales modèle de la maladie de Huntington
Poster Presented at: CDRV Conference, Sherbrooke, Quebec (May 2018)
27. (2018) Majed AlOtaibi, Mélissa Lessard-Beaudoin, Amel Loudghi, Raphaël, Chouinard-Watkins, Melanie Plourde, Frederic Calon, C. Alexandre Castellano, Stephen Cunnane, Pierrette Gaudreau, and Rona K. Graham. The role of olfactory dysfunction in the pathogenesis of Alzheimer disease.
Poster Presented at: Colloque Merck-FMSS, Sherbrookk, Quebec (May 2018)
28. (2017) M Lessard-Beaudoin, M Laroche, Libo Yu-Tager, Hoa Nguyen and RK Graham. Dynamic nature of olfactory bulb atrophy and early caspase activation in the BACHD rat models.
Poster Presented at: Canadian Association for Neuroscience Meeting, Montreal, Quebec (May 2017)
29. (2017) M Laroche, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, MR Hayden, MA Pouladi and RK Graham. Early olfactory behavior deficits associated with olfactory bulb atrophy and caspase activation in YAC128 HD model.
Poster Presented at: Research Center on Aging Research Day, Sherbrooke, Quebec (June 2017)
30. (2017) Majed AlOtaibi, Mélissa Lessard-Beaudoin, Raphaël Chouinard-Watkins, Frederic Calon, Melanie Plourde and RK Graham. The role of olfactory dysfunction in the pathogenesis of AD.
Poster Presented at: Research Center on Aging Research Day, Sherbrooke, Quebec (June 2017)
31. (2017) M Laroche, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, MR Hayden, MA Pouladi and RK Graham. Early olfactory behaviour deficits associated with structural and functional alterations in the olfactory system in an HD model.
Poster Presented at: Gordon CAG triplet disease Conference, Vermont, U.S.A (June 2017)
32. (2017) Rona Graham1, 2, Majed Al Otaibi 1,2, Melissa LessardBeaudoin1, 2, Amel Loudghi1, 2, Raphaël ChouinardWatkins1, 2, Melanie Plourde1, 2, Frederic Calon3, Alexandre Castellano1, 2, Stephen Cunnane1, 2, Hélène Payette1,2, Pierrette Gaudreau4 The role of olfactory dysfunction in the pathogenesis of Alzheimer disease.
Poster Presented at: International Society of Neurochemistry, Paris, France (August 2017)
33. (2017) Majed AlOtaibi, Mélissa Lessard-Beaudoin, Amel Loudghi, Raphaël, Chouinard-Watkins, Melanie Plourde, Frederic Calon, C. Alexandre Castellano, Stephen Cunnane, Hélène Payette, Pierrette Gaudreau, and Rona K. Graham. Decrease in Olfactory Cortex Volume and Alterations in Caspase Expression in the Olfactory Bulb in the Pathogenesis of AD.
Oral - Presented at: Conference on Cognitive Neuroscience, Dubai, UAE, (Dec 2017) – Best presentation award
34. (2016) Amal Loudghi1,2, Majed Alotaibi 1,2 , Melissa Lessard-Beaudoin1,2, and Rona K. Graham1,2 La majorité de personnes âgées inconscientes de leur dysfonction olfactive : Répercussion sur leur sécurité.
Poster Presented at: Journée de recherche scientifique [Université de Sherbrooke] (Sept 2016)
35. (2016) Carolyne-Mary Lowry1, Rona Graham1, Michel Lebel2 and J. Richard Wagner1. Role of Vitamin C in TET-mediated oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in the brain of young mice.
Presented at: Canadian Oxidative Stress Consortium, Guelph, Ontairo (April 2016)
36. (2016) Majed AlOtaibi, Mélissa Lessard-Beaudoin, Raphaël Chouinard-Watkins, Frederic Calon, Melanie Plourde and RK Graham. The role of olfactory dysfunction among the aging population.
Presented at: Journée de recherche scientifique [Université de Sherbrooke (May 2016); CDRV (May 2016)]
CNS Conference (oral), Sherbrooke, QC (Dec 2016)
37. (2016) RK Graham, M Laroche, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, Libo Yu-Tager, MR Hayden, Hoa Nguyen and MA Pouladi. Early olfactory behavior deficits associated with olfactory bulb atrophy and caspase-8 activation in HD rodent models.
Présenté à: European HD Network Conference, The Hague, Netherlands (Sept 2016)
38. (2015) M Laroche, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidyi, K Yu-Tager, H Nguyen, MR Hayden, MA Pouladi and RK Graham. Caspase activation in the olfactory bulb and alterations in neurogenesis observed early in HD rodent models.
Presented at: Society for Neuroscience Conference, Chicago, USA (October)
Journée de recherche scientifique [CDRV]
39. (2015) Anthony Pinçon, Stefano Cataldi, Melissa Laroche, Melissa Lessard-Beaudoin, Marie-Josée Demers, Matthew
J Farrer, Austen Milnerwood and Rona K Graham. Potential role of apoptosis and inflammation in the olfactory dysfunction and altered neurogenesis in human wild type LRRK2 transgenic PD mice
Presented at: Gordon Research Conference – Parkinson Disease
40. (2015) M Laroche, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidyi, K Yu-Tager, H Nguyen, MR Hayden, MA Pouladi and RK Graham. Le rôle du déclin précoce du système olfactif dans la maladie de Huntington.
Presented at: Journée de recherche scientifique [Université de Sherbrooke]
41. (2015) M Lessard-Beaudoin, MJ Demers, M Laroche, G Grenier and RK Graham. The role of STK3 in neuro-degeneration: Brain region-specific alterations in the aging process.
Presented at: Society for Neuroscience Conference, Chicago, USA (October)
Journée de recherche scientifique [Université de Sherbrooke; CDRV]
42. (2014) M Laroche, MA Pouladi, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, S Franciosi, MR Hayden and RK Graham. Huntington disease and olfactory dysfunction: structural abnormalities of the olfactory system and early caspase activation in the olfactory bulb are observed in HD mouse models.
Presented at: Society for Neuroscience Conference, Washington, USA
European Huntington disease Network, Barcelona, Spain
43. (2014) M Lessard-Beaudoin, MJ Demers, M Laroche, G Grenier and RK Graham. Age-related changes in brain region weights are associated with caspase activation in wild type C57Bl6 mice.
Presented at: Canadian Neuroscience Meeting, Montreal, QC.
44. (2014) M Lessard-Beaudoin, MJ Demers, M Laroche, G Grenier et R Graham. Deux nouveaux substrats de la caspase-6, DAXX et STK3, voient leur expression modifiée avec le vieillissement.
Presented at: Journée de recherche scientifique [Université de Sherbrooke et CDRV]; Club de Recherches Cliniques du Québec, Saint Adèle, QC, Journée Pharee, Orford, QC.
45. (2014) MJ Demers, K Girling, S Zhang, YT Wang and RK Graham. Activation of caspase-6 and cleavage of STK3 in an early event in an in vitro model of stroke.
Presented at: Canadian Neuroscience Meeting, Montreal, QC.
46. (2014) M. Laroche, M.-J. Demers, M. Lessard-Beaudoin et R.K. Graham. Le rôle du déclin précoce du système olfactif dans la maladie de Huntington.
Presented at: Journée de recherche scientifique [Université de Sherbrooke et CDRV]; conférences du Centre de Neuroscience à Sherbrooke (CNS), Réseau Québécois de recherché, Sherbrooke, QC.
47. (2014) NH Skotte, MA Pouladi, K Huynh, TT Nielsen, RK Graham, A Nørremølle and MR Hayden. Insulin-like
growth factor 1 signalling in Huntington's disease.
Presented at: Society for Neuroscience Conference, Washington, USA.
48. (2013) MJ Demers, K Girling, S Zhang, YT Wang and RK Graham. Early activation of caspase-6 and cleavage of caspase-6 substrates in an in vitro model of stroke.
Presented at: The International Society of Autonomic Neuroscience, Giessen, Germany.
Society for Neuroscience Conference, San Diego, USA.
49. (2013) MJ Demers, M Laroche, G Grenier and RK Graham. The role of apoptotic mechanisms in the pathophysiology of aging.
Presented at: The International Society of Autonomic Neuroscience, Giessen, Germany.
50. (2012) Rona K. Graham, Sean-Patrick Riechers, Stefanie Butland, Yu Deng, Niels Skotte, Jenny Russ, Vinayagam Arunachalam, Erich Wanker and Michael R. Hayden. Characterization of the caspase-6 interactome identifies novel substrates that play a role in the pathogenesis of HD.
Presented at: Quebec symposium on neurodegenerative disease therapeutics, Quebec, Quebec.
51. (2012) Rona K. Graham, Sean-Patrick Riechers, Stefanie Butland, Yu Deng1, Niels Skotte, Jenny Russ, Vinayagam Arunachalam, Erich Wanker and Michael R. Hayden. Characterization of the caspase-6 interactome identifies novel substrates that play a role in the pathogenesis of HD.
Presented at: Canadian Neuroscience Meeting, Vancouver, B.C.
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