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Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice
Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice
Melissa Lessard-Beaudoin,Laura M. Gonzalez,Majed AlOtaibi,Raphaël Chouinard-Watkins,Melanie Plourde,Frederic Calon,Rona K. Graham
First published: 21 September 2021 https://doi.org/10.1111/ejn.15472
Peer-Reviewed Manuscripts
2021
64. Melissa Lessard-Beaudoin, Laura M Gonzales, Majed AlOtaibi, Raphaël Chouinard Watkins, Melanie Plourde, Frederic Calon and RK Graham. Diet enriched in omega-3 fatty acids reduces olfactory system deficits in APOE4 transgenic mice. European Journal of Neuroscience Accepted Sept 2021
2020
63. Majed AlOtaibi, Melissa Lessard-Beaudoin, Christian-Alexandre Castellano, Denis Gris, Stephen C. Cunnane and Rona K. Graham. Volumetric MRI demonstrates atrophy of the olfactory cortex in AD. Current Alzheimer Research. 2020;17(10):904-915.
62. M Laroche, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, Emma Peachey, Blair R. Leavitt, MA Pouladi and RK Graham. Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model. Human Molecular Genetics 2020 29(13): 2134-2147.
2019
61. Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierre e Gaudreau and Rona K Graham. Unawareness of Olfactory Dysfunction on in Older Adults. International Journal of Neurology and Neurotherapy. 2019 6 (2):1-10, DOI: 10.23937/2378-3001/1410086
60. Lessard-Beaudoin M, Yu-Taeger L, Laroche M, Singer E, Riess O, Nguyen HHP, Graham RK. (2019)
Olfactory bulb atrophy and caspase activation observed in the BACHD rat models of Huntington disease.
Neurobiol Dis. 2019 125:219-231.
2018
59. K Girling, MJ Demers, Jean Laine, S Zhang YT Wang and RK Graham. (2018) Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in an NMDA receptor-mediated excitotoxicity. Journal of Neuroscience research, 96 (3): 391-406.
2016
58. Sean-Patrick Riechers, Stefanie Butland, Yu Deng, Niels Skotte, Dagmar E Ehrnhoefer, Jenny Russ, Jean Laine, Melissa Laroche, Mahmoud A. Pouladi, Erich E. Wanker , Michael R. Hayden and Rona K. Graham. (2016) Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD. Human Molecular Genetics, 25(8): 1600-1618.
57. Mélissa Lessard-Beaudoin, Mélissa Laroche, Marie-Josée Demers, Catherine Duclos, Jean-Bernard Denault, Guillaume Grenier, Sean-Patrick Riechers, Erich E. Wanker and Rona K. Graham. (2016) Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice. Biogerontology, 17(5-6):817-828.
56. Mélissa Lessard-Beaudoin, Mélissa Laroche, Marie-Josée Demers, Amal Loudghi, Jean-Bernard Denault, Guillaume Grenier, Sean-Patrick Riechers, Erich E. Wanker and Rona K. Graham. (2016) Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process. Neurobiology of Aging, 47:50-62.
2015
55. Mélissa Lessard-Beaudoin, Mélissa Laroche, Marie-Josée Demers, Guillaume Grenier and Rona K. Graham. (2015) Characterisation of age-associated changes in peripheral organ and brain regions weights in C57BL/6 mice. Experimental Gerontology. 63: 27-34.
54. M Biet, N Morin, M Lessard-Beaudoin, RK Graham, S Duss, J Gagne, NT Sanon, L Carmant and R Dumaine. (2015) Prolongation of action potential duration and qt interval during epilepsy linked to increased contribution of neuronal sodium channels to cardiac late na+ current: potential mechanism for sudden death in epilepsy. Circ Arrhythm Electrophysiol. 8(4):912-20.
53. Stroedicke M, Bounab Y, Strempel N, Klockmeier K, Yigit S, Friedrich RP, Chaurasia G, Li S, Hesse F, Riechers SP, Russ J, Nicoletti C, Boeddrich A, Wiglenda T, Haenig C, Schnoegl S, Fournier D, Graham RK, Hayden MR, Sigrist S, Bates GP, Priller J, Andrade-Navarro MA, Futschik ME, Wanker EE. (2015) Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Genome Res. 2015 25(5):701-13.
52. Bibiana K Wong, Dagmar E Ehrnhoefer, Rona K Graham, Dale D Martin, Safia Ladha; Valeria Uribe, Lisa M Stanek, Sonia Franciosi, Xiaofan Qiu et al. (2015) Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. Neurobiology of disease. 76:24-36.
2014
51. Butland SL, Sanders SS, Schmidt ME, Riechers SP, Lin DT, Martin DD, Vaid K, Graham RK, Singaraja RR, Wanker EE, Conibear E, Hayden MR. (2014) The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Hum Mol Genet. Apr 15. [Epub ahead of print].
2013
50. Sonia Marco, Albert Giralt, Milos M. Petrovic, Mahmoud A. Pouladi, Rebeca Martínez-Turrillas, José Martínez-Hernández, Linda Kaltenbach, Jesús Torres-Peraza, Rona K. Graham, Masahiko Watanabe, Rafael Luján, Nobuki Nakanishi, Stuart A. Lipton, Donald C. Lo, Michael R. Hayden, Jordi Alberch, John F. Wesseling, Isabel Pérez-Otaño. (2013) Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington Disease models. Nature Medicine. 19(8):1030-1038
2012
49. Graham RK, Deng Y, Pouladi MA, Vaid K, Ehrnhoefer D, Southwell AL, Bissada N, Franciosi S and Hayden MR. (2012) Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo. JHD 1(2):243-260
48. Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR. (2012) Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6 deficient mice. Hum Mol Genet. 21(9):1954-67
47.Pouladi MA, Brillaud E, Xie Y, Conforti P, Graham RK, Ehrnhoefer DE, Franciosi S, Zhang W, Poucheret P, Compte E, Maurel JC, Zuccato C, Cattaneo E, Néri C, Hayden MR. (2012) NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease. Neurobiol Dis. 2012 Dec;48(3):282-9.
46. Waldron-Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, Graham RK, Hayden MR, Hou Z, Mori S, Swing D, Pletnikov M, Duan W, Tessarollo L, Ross CA. (2012) Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin. J Neurosci. 2012 Jan 4;32(1):183-93.
2011
45. Graham RK, Ehrnhoefer DE and Hayden MR. Caspase-6 in Neurodegeneration. Trends Neurosci. 2011 Dec;34(12):646-56.
44. Carroll J, Southwell AL, Graham RK, Lerch JP, Ehrnhoefer D, Li-Ping Cao, Zhang W, Hung G, Bissada N and Hayden MR. (2011) Mice lacking caspase-2 are protected from excitotoxicity and behavioral phenotypes, but not pathology, in the YAC128 model of Huntington Disease. Mol Neurodegener. 2011 Aug 19;6:59.
2010
43. Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Bissada N, Faull R, Gray M, Yang XW, Raymond LA, and Hayden MR. Proteolysis at the caspase-6 site of mutant huntingtin influences caspase-6 activation in vivo. (2010) J. Neurosci. 30(45):15019-29.
42. Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Warby S, GLu, Leavitt BR and Hayden MR. The phosphorylation of htt in YAC128 neurons is influenced by PP1/PP2A and dysfunction in glutamatergic and dopaminergic pathways. (2010) J. Neurosci.30(43):14318-29.
41. Pouladi, M.A., Xie, Y., Skotte, N.H., Ehrnhoefer, D.E., Graham, R.K., Kim, J.E., Bissada, N., Yang, X.W., Paganetti, P., Friedlander, R.M., Leavitt, B.R., Hayden, M.R. (2010) Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression. Hum Mol Genet.19(8):1528-38.
40. Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA.. (2010) Increased extrasynaptic NMDA receptor expression and activity in a transgenic mouse model of HD. Neuron 65(2):178-90.
39. Okamoto S, Pouladi MA, Talantova M, Yao D, Clemente A, Kaul M, Bossy-Wetzel E, Graham RK, Zhang D, Chen H, Tong G, Hayden MR, Lipton SA. (2009) Tuning of synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingin. Nat Med.15(12):1407-13.
2009
38. Graham RK, Pouladi MA, Joshi P, Lu G, Deng Y, Wu NP, Figueroa BE, Metzler M, André VM, Slow EJ, Raymond L, Friedlander R, Levine MS, Leavitt BR, Hayden MR. (2009). Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease. J Neurosci. 29(7):2193-204.
37. Pouladi MA, Graham RK, Karasinska JM, Xie Y, Santos RD, Petersén A, Hayden MR. Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin. (2009).
Brain. 132(Pt 4):919-32
36. Ratovitski T, Gucek M, Jiang H, Chighladze E, Waldron E, D'Ambola J, Hou Z, Liang Y, Poirer MA, Hirschhorn RR, Graham RK, Hayden MR, Cole RN, Ross CA. (2009). Mutant Huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells. JBC. 284(16):10855-67.
2008
35. Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR. (2008) Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus. Hum Mol Genet. 17(15):2390-404
34. Warby SC, Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR. (2008) Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments. Mol Cell Neurosci. 40(2):121-7.
33. Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I. (2008) Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiol Dis. 31(1):80-8.
32. Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK, Hayden MR, Raymond LA. (2008) Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity. J Neurosci. 28(48):12725-35.
31. Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. (2008) Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum Mol Genet. 17(17):2738-51.
2007
30. Benn CL., Slow EJ., Farrell LA., Graham RK., Deng Y., Hayden MR., and Cha JH. (2007) Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington’s Disease. J Neurosci, 147(2):354-72.
29. Van Raamsdonk,J.M., Metzler,M., Slow,E., Pearson,J., Schwab,C., Carroll,J., Graham,R.K., Leavitt,B.R., and Hayden,M.R. (2007) Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiol.Dis.. 26(1):189-200.
28. Ratovitski T, Nakamura M, D'Ambola J, Chighladze E, Liang Y, Wang W, Graham R, Hayden MR, Borchelt DR,
Hirschhorn RR, Ross CA. (2007) N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle. 6(23):2970-81.
2006
27. Graham,R.K., Deng,Y., Slow,E.J., Bissada,N., Lu,G., Pearson,J., Bertram,L., Shehadeh,J., Murphy,Z., Warby,S., Roy,S., Wellington,C., Leavitt,B.R., Raymond,L.A., Nicholson,D.W., Hayden,M.R. (2006) Cleavage at the caspase-6 site in huntingtin is required for mutant huntingtin mediated neuronal dysfunction and degeneration. Cell. 125, 1179-1191.
26. Graham,R.K., Slow,E.J., Deng,Y., Bissada,N., Lu,G., Pearson,J., Shehadeh,J., Leavitt,B.R., Raymond,L.A., Hayden,M.R. (2006) Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models. Neurobiol. Dis., 21, 444-455.
25. Slow,E.J., Graham,R.K., Hayden,M.R. (2006) To be or not to be toxic: aggregations in HD and AD. Trends in Genetics. 22, 408-411.
24. Guidetti,P., Bates,G.P., Graham,R.K., Hayden,M.R., Leavitt,B.R., Macdonald,M.E., Slow,E.J., Wheeler,V.C., Woodman,B., Schwarcz,R. (2006) Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiol Dis., 23, 190-7
23. Leavitt,B.R., Raamsdonk,J.M., Shehadeh,J., Fernandes,H., Murphy,Z., Graham,R.K., Wellington,C.L., Raymond,L.A., Hayden,M.R. (2006) Wild-type huntingtin protects neurons from excitotoxicity. J. Neurochem., 96, 1121-1129.
22. Shehadeh,J., Fernandes,H.B., Zeron Mullins,M.M., Graham,R.K., Leavitt,B.R., Hayden,M.R., Raymond,L.A.
(2006) Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic
mouse model of Huntington disease. Neurobiol. Dis., 21, 392-403.
2005
21. Graham,R.K and Slow, EJ., Osmand,A.P., Devon,R.S., Lu,G., Deng,Y., Pearson,J., Vaid,K., Bissada,N.,
Wetzel,R., Leavitt,B.R., Hayden,M.R. (2005) Absence of behavioral abnormalities and neurodegeneration in vivo
despite widespread neuronal huntingtin inclusions. PNAS. 102, 11402-11407.
2004-1993
20. Saleh,M., Vaillancourt,J., Graham,R.K., Huyck,M., Srinivasula,S.M., Alnemri,E.S., Steinberg,M.H., Nolan,V.,
Baldwin,C., Hotchkiss,R.S., Buchman,T.G., Zehnbauer,B.A., Hayden,M.R., Farrer,L., Roy,S., Nicholson,D.W.
(2004) Differential modulation of endotoxin response by human casp12 polymorphisms. Nature, 429, 75-79.
19. Slow,E.J., van,R.J., Rogers,D., Coleman,S.H., Graham,R.K., Deng,Y., Oh,R., Bissada,N., Hossain,S.M.,
Yang,Y.Z., Li,X.J., Simpson,E.M., Gutekunst,C.A., Leavitt,B.R., Hayden,M.R. (2003) Selective striatal neuronal loss
in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet., 12, 1555-1567.
18. Wellington,C.L., Ellerby,L.M., Gutekunst,C.A., Rogers,D., Warby,S., Graham,R.K., Loubser,O., van,R.J.,
Singaraja,R., Yang,Y.Z., Gafni,J., Bredesen,D., Hersch,S.M., Leavitt,B.R., Roy,S., Nicholson,D.W., Hayden,M.R.
(2002) Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J. Neurosci.,
22, 7862-7872.
17. Metzler,M., Chen,N., Helgason,C.D., Graham,R.K., Nichol,K., McCutcheon,K., Nasir,J., Humphries,R.K.,
Raymond,L.A., Hayden,M.R. (1999) Life without huntingtin: normal differentiation into functional neurons. J.
Neurochem., 72, 1009-1018.
16. Kalchman,M.A., Koide,H.B., McCutcheon,K., Graham,R.K., Nichol,K., Nishiyama,K., Kazemi-Esfarjani,P.,
Lynn,F.C., Wellington,C., Metzler,M., Goldberg,Y.P., Kanazawa,I., Gietz,R.D., Hayden,M.R. (1997) HIP1, a human
homologue of S. cerevisiae Sla2p, interacts with membrane-associated htt in the brain. Nat. Genet. 16, 44-53.
15. Goldberg,Y.P., Kalchman,M.A., Metzler,M., Nasir,J., Zeisler,J., Graham,R., Koide,H.B., O'Kusky,J., Sharp,A.H.,
Ross,C.A., Jirik,F., Hayden,M.R. (1996) Absence of disease phenotype and intergenerational stability of the CAG
repeat in transgenic mice expressing the human Huntington disease transcript. Hum. Mol. Genet., 5, 177-185.
14. Goldberg,Y.P., Nicholson,D.W., Rasper,D.M., Kalchman,M.A., Koide,H.B., Graham,R.K., Bromm,M., Kazemi-
Esfarjani,P., Thornberry,N.A., Vaillancourt,J.P., Hayden,M.R. (1996) Cleavage of huntingtin by apopain, a
proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat. Genet., 13, 442-449.
13. Kalchman,M.A., Graham,R.K., Xia,G., Koide,H.B., Hodgson,J.G., Graham,K.C., Goldberg,Y.P., Gietz,R.D.,
Pickart,C.M., Hayden,M.R. (1996) Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating
enzyme. J. Biol. Chem., 271, 19385-19394.
12. Lin,B., Nasir,J., McDonald,H., Graham,R., Rommens,J.M., Goldberg,Y.P., Hayden,M.R. (1995) Genomic
organization of the human alpha-adducin gene and its alternately spliced isoforms. Genomics, 25, 93-99.
11. Lin,B., Nasir,J., MacDonald,H., Hutchinson,G., Graham,R.K., Rommens,J.M., Hayden,M.R. (1994) Sequence of
the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet
(CCG) repeat [corrected]. Hum. Mol. Genet., 3, 85-92.
10. Riess,O., Thies,U., Siedlaczck,I., Potisek,S., Graham,R., Theilmann,J., Grimm,T., Epplen,J.T., Hayden,M.R.
(1994) Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16. Genomics, 19,
298-302.
9. Andrew,S.E., Goldberg,Y.P., Kremer,B., Telenius,H., Theilmann,J., Adam,S., Starr,E., Squitieri,F., Lin,B.,
Kalchman,M.A., Graham,R.K., Hayden,M.R. (1993) The relationship between trinucleotide (CAG) repeat length
and clinical features of Huntington's disease. Nat. Genet., 4, 398-403.
8. Goldberg,Y.P., Rommens,J.M., Andrew,S.E., Hutchinson,G.B., Lin,B., Theilmann,J., Graham,R., Glaves,M.L.,
Starr,E., McDonald,H., Nasir,J., Schappert,K., Kalchman,M.A., Clarke,L.A., Hayden,M.R. (1993) Identification of an
Alu retrotransposition event in close proximity to a strong candidate gene for Huntington's disease. Nature, 362,
370-373.
7. Goldberg,Y.P., Kremer,B., Andrew,S.E., Theilmann,J., Graham,R.K., Squitieri,F., Telenius,H., Adam,S.,
Sajoo,A., Starr,E., Heiberg,A., Wolff,G., Hayden,M.R. (1993) Molecular analysis of new mutations for Huntington's
disease: intermediate alleles and sex of origin effects. Nat. Genet., 5, 174-179.
6. Hutchinson,G.B., Andrew,S.E., McDonald,H., Goldberg,Y.P., Graham,R., Rommens,J.M., Hayden,M.R. (1993)
An Alu element retroposition in two families with Huntington disease defines a new active Alu subfamily. Nucleic
Acids Res., 21, 3379-3383.
5. Lin,B., Rommens,J.M., Graham,R.K., Kalchman,M., MacDonald,H., Nasir,J., Delaney,A., Goldberg,Y.P.,
Hayden,M.R. (1993) Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species
with variable tissue expression. Hum. Mol. Genet., 2, 1541-1545.
4. Rommens,J.M., Lin,B., Hutchinson,G.B., Andrew,S.E., Goldberg,Y.P., Glaves,M.L., Graham,R., Lai,V.,
McArthur,J., Nasir,J., Theilmann,J., MacDonald,H., Kalchman,M., Clarke,L.A., Schappert,K., Hayden,M.R. (1993) A
transcription map of the region containing the Huntington disease gene. Hum. Mol. Genet., 2, 901-907.
3. Weber,B., Riess,O., Daneshvar,H., Graham,R., Hayden,M.R. (1993) (CA)n-dinucleotide repeat at the PDEB locus in 4p16.3. Hum. Mol. Genet., 2, 827.
2. Goldberg,Y.P., Lin,B.Y., Andrew,S.E., Nasir,J., Graham,R., Glaves,M.L., Hutchinson,G., Theilmann,J.,
Ginzinger,D.G., Schappert,K., Clarke,L.A., Rommens,J.M., Hayden,M.R. (1992) Cloning and mapping of the alpha-
adducin gene close to D4S95 and assessment of its relationship to Huntington disease. Hum. Mol. Genet., 1, 669
675.
1. Weber,B., Riess,O., Wolff,G., Andrew,S., Collins,C., Graham,R., Theilmann,J., Hayden,M.R. (1992) Delineation
of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease. Nat.
Genet., 2, 216-222.
Book Chapters
1.Mahbubul Huq,A.H.M., Hackam,A., Graham,R.K., Wellington,C.L., Hayden,M.R. (1998) “Molecular Pathogenesis
of Huntington’s Disease: Biochemical Studies of Huntingtin” in Genetic Instabilities and Hereditary Neurological
Diseases. Chapter 24, pp 325-354.
2. Warby,, S. Graham, RK. and Hayden, MR. (2007) Huntington Disease. GeneReviews.
3. Warby,, S. Graham, RK. and Hayden, MR. (2010) Huntington Disease. GeneReviews.
4. Warby,, S. Graham, RK. and Hayden, MR. (2014) Huntington Disease. GeneReviews.
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