October 17-18, 1681: William Penn granted 1,250 acres to William Pennington.

June 15-16, 1716: Pennington sold the property to Joseph Kirkbride.

December 24, 1717: Kirkbride sold half of the property to Thomas Stevenson.

November 15, 1718: Hans Joest (Yost, Jost) Heijt (Hite, Height) purchased 600 acres from Kirkbride and Stevenson. Heijt constructed the first part of the house and the gristmill during his ownership.  Heijt married Anna Maria du Bois and had eight children.

Heijt eventually moved to the Shenandoah Valley and became one of the largest landowners in that area.

Jan Pawling (John Pauling), a major land owner in southeastern Pennsylvania, purchased 500 acres, including the house and gristmill, for £540. John married Ephia Dewitt and had seven children. He died in 1733, and his family rented out the mill and the house.

On December 4, 1747, Pawling's heirs sold 445 ½ acres of the property to Peter Penebacker (Pannebacker, Pennypacker) for £780. Peter had purchased the mill and 55 acres prior to this. During his ownership, a sawmill and a fulling mill were added to the property along with an addition to the house. With the three mills, the property became known as Pennypacker Mills. 

Peter married Elizabeth Keyser and had nine children. The gristmill and 115 acres were sold to Adam Prutesman on June 19, 1762. In his will of 1765, Peter stated that his son Samuel would receive the property containing the house and that his wife shall have the privilege of the two Rooms at the East end of my house where I now Live in...

Samuel Penebacker (Pennypacker), through his father’s will, received the property consisting of the house and 125 acres which was appraised at £900 on Aug. 28, 1770. Samuel married Hannah Gesbert and had eight children. During his ownership, in the fall of 1777, the Continental Army under General George Washington encamped on the property, referring to it as "Camp at Pennypacker’s Mills." In 1783, Samuel was listed as owning 171 acres, five horses, eight cattle, ten sheep, and one enslaved person. In 1787, he built or reconstructed the barn. 

Samuel Pennypacker Jr. was born on the property on February 8, 1779. Samuel, through his father's will, received the property consisting of 125 acres on March 10, 1826. He married Catharine Wireman and had eight children. He spent his entire life of 84 years on the property and had amassed $20,596.43 at the time of his death.

John Detweiler married Samuel's daughter, Anna Pennypacker, and they had four daughters. On April 2, 1864, John Detweiler, already residing on the property, bought 97 acres for $6,706.56 through the terms of his father-in-law's will. It is most likely during John's ownership that the porch was added to the house. John died without a will. His wife, Anna, lived in the mansion until her death in 1895. Like her father, she spent her entire life of 77 years on the property.

Josiah Hunsicker married Katherine Detweiler and had an acre conveyed to him in 1872. He purchased an additional acre in 1874. Since Josiah Hunsicker's father, John Detweiler, died without a will, his wife Ann and son-in-law Josiah sold the property to John Markley on April 22, 1882 for $4,713.12. Josiah Hunsicker then purchased the property back from Markley on the same day for the same amount for tax reasons. Josiah Hunsicker died on January 4, 1900 with a debt of over $5,500. In 1897, the Historical Society of Montgomery County erected a large stone monument to commemorate the location of the Revolutionary War encampment.