Publications
Publications
Poursharifi Lab members
* co-first author
** co-corresponding author
Poursharifi P*,**, Schmitt C*, Chenier I, Leung YH, Oppong AK, Bai Y, Klein L-L, Vilanou L, Al-Mass A, Lussier R, Abu-Farha M, Abubaker J, Al-Mulla, Dumais É, Flamand N, Provost N, Bernard C, Delerive P, Peyot M-L, Madiraju SRM, Prentki M**. ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2026;1871;1: 159694.
Poursharifi P**, Attané C, Klein L-L, Calce S-I, Mootoosamy C, Shea J, Chenier I, Ghosh A, Schmitt C, Al-Mass A, Bai Y, Roxane L, Leung YH, Oppong AK, Gauthier M-S, Coulombe B, Peyot M-L, Tchernof A, Madiraju SRM, Prentki M**. Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity. Molecular Metabolism, 2025;29;101:102241.
Poursharifi P, Madiraju SRM, Oppong AK, Kajimura S, Blondin D, Prentki M. Glycerolipid cycling in thermogenesis, energy homeostasis, signaling, and diseases. Physiological Reviews, 2025;105(4):2449-2499.
Poursharifi P**, Schmitt C, Chenier I, Leung YH, Oppong AK, Bai Y, Klein L-L, Al-Mass A, Lussier R, Abu-Farha M, Abubaker J, Al-Mulla F, Peyot M-L, Madiraju SRM, Prentki M**. ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice. Molecular Metabolism, 2023; 78:101822.
Al-Mass A, Poursharifi P, Peyot M-L, Lussier R, Chenier I, Leung YH, Ghosh A, Oppong A, Possik E, Mugabo Y, Ahmad R, Sladek R, Madiraju SRM, Almulla F, Prentki M. Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia. Molecular Metabolism, 2022; 66:101609.
Al-Mass A, Poursharifi P, Peyot M-L, Lussier R, Levens EJ, Guida J, Mugabo Y, Possik E, Ahmad R, Al-Mulla F, Sladek R, Madiraju SRM, Prentki M. Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress. Molecular Metabolism, 2022; 60:101471.
Poursharifi P, Attane C, Mugabo Y, Almass A, Ghosh A, Schmitt C, Zhao S, Guida J, Lussier R, Erb H, Chénier I, Peyot ML, Joly E, Noll C, Carpentier AC, Madiraju SRM, Prentki M. Adipose ABHD6 regulates tolerance to cold and thermogenic programs. JCI Insight, 2020; 5(24):e140294.
Attendees of the Danish Diabetes Academy Winter School 2019. Next generation diabetes scientists shape global research culture: A reflective proposal from postdoctoral researchers in diabetes research. Acta Physiologica, 2020; 229(2):e13455.
Poursharifi P, Madiraju SRM, and Prentki M. Monoacylglycerol signaling and ABHD6 in health and disease. Diabetes, Obesity and Metabolism, 2017; 19 (Suppl 1):76-89.
Attane C, Peyot M-L, Lussier R, Poursharifi P, Zhao As, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman N.B, Mitchell G.A, Simons B, Madiraju SRM, Joly E, and Prentki M. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. Diabetologia, 2016;59(12):2654-63.
Zhao S, Mugabo Y, Thomas G, Attane C, Iglesias J, Poursharifi P, Zhang D, Nguyen TN, Prentki R, Peyot ML, Joly E, Tobin S, Fulton S, Brown M, Madiraju SRM, and Prentki M. α/β hydrolase domain-6 deletion induces adipose browning and prevents obesity and type-2 diabetes. Cell Reports, 2016; 29;14(12):2872-88.
Mugabo Y, Zhao S, Seifried A, Gezzar S, AlMass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SRM, and Prentki M. Identification of a mammalian glycerol-3-phosphate phosphatase: role in metabolic control and signaling in pancreatic β–cells and hepatocytes. Proceedings of the National Academy of Sciences of the USA, 2016; 26;113(4):E430-9.
Zhao S*, Poursharifi P*, Mugabo Y, Levens EJ, Vivot K, Attane C, Iglesias J, Peyot ML, Joly E, Madiraju SRM, and Prentki M. α/β hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli. Molecular Metabolism, 2015; 4(12):940-950.
Doyon CY, Tremblay A, Rioux L-E, Rhéaume C, Cianflone K, Poursharifi P, and Turgeon SL. Acute effects of protein composition and fibre enrichment of yogurt consumed as snacks on appetite sensations and subsequent Ad libitum energy intake in healthy men. Applied Physiology, Nutrition, and Metabolism, 2015; 40(10):980-9.
Rezvani R, Gupta A, Smith J, Poursharifi P, Marceau P, Pérusse L, Bouchard C, Tchernof A, and Cianflone K. Cross-sectional associations of acylation stimulating protein (ASP) and adipose tissue gene expression with estradiol and progesterone in pre- and postmenopausal women. Clinical Endocrinology, 2014; 81(5):736-45.
Gupta A, Rezvani R, Lapointe M, Poursharifi P, Marceau P, Tiwari S, Tchernof A, and Cianflone K. Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese women. PLoS One, 2014; 9(4):e95478.
Poursharifi P, Rezvani R, Gupta A, Laponite M, Marceau P, Tchernof A, and Cianflone K. Association of immune and metabolic receptors C5aR and C5L2 with adiposity in women. Mediators of Inflammation, 2014; 2014:413921.
Poursharifi P, Lapointe M, Fisette A, Lu H, Roy C, Munkonda MN, Fairlie DP, and Cianflone K. C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue. Molecular and Cellular Endocrinology, 2014; 382(1):325-33.
Poursharifi P, Lapointe M, Pétrin D, Devost D, Gauvreau D, Hébert TH, and Cianflone K. C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology. Cellular Signalling, 2013; 25(4):910-8.
Fisette A, Poursharifi P, Oikonomopoulou K, Munkonda MN, Lapointe M, and Cianflone K. Paradoxical glucose-sensitizing yet proinflammatory effects of acute ASP administration in mice. Mediators of Inflammation, 2013; 2013:713284.
Roy C, Gupta A, Fisette A, Lapointe M, Poursharifi P, Richard D, Lu H, Lu B, Gerard N, Gerard C, and Cianflone K. C5a receptor deficiency alters energy utilization and fat storage. PLoS One, 2013; 8(5):e62531.
Miegueu P, St-Pierre D, Lapointe M, Poursharifi P, Lu H, Gupta A, and Cianflone K. Substance P decreases fat storage and increases adipocytokine production in 3T3-L1 adipocytes. American Journal of Physiology, 2013; 304(4):G420-7.
Tom F-Q, Gauvreau D, Lapointe M, Lu HL, Poursharifi P, Luo X-P, and Cianflone K. Differential chemoattractant response in adipocytes and macrophages to the action of acylation stimulating protein. European Journal of Cell Biology, 2013; 92(2):61-9.
Saghiri R, Ghashghai N, Movaseghi Sh, Poursharifi P, Jalilfar Sh, Ahmadi Bidhendi M, Ghazizadeh L, and Ebrahimi-Rad M. Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern. Rheumatology International, 2012; 32(6):1633-8.
Poursharifi P, Saghiri R, Ebrahimi-Rad M, Nazem H, Pourpak Z, Moin M, and Shams S. Adenosine deaminase in patients with primary immunodeficiency syndromes: the analysis of serum ADA1 and ADA2 activities. Clinical Biochemistry, 2009; 42(13-14):1438-43.