Curriculum Vitae
Curriculum Vitae
Doctor of Philosophy, Biomedical Informatics, Stony Brook University, NY, USA
CGPA: 3.9/4
Tissue specificity, Cancer, Epigenetic data analyses, Statistics, AI/ML, LLMs
Master of Science, Bioinformatics and Genomics, Penn State University, PA, USA
CGPA: 3.78/4
Impact of background variants in 2-hit model of Autism, Fly husbandry and Imaging, GWAS
Bachelor of Engineering, Biotechnology, R.V. College of Engineering, India
CGPA: 8.58/10
Molecular docking, MD simulations, Pharmacophore modeling, Biostatistics
Dissertation Research
Methods and analysis pipelines to identify tissue specific transcript variants, decipher their role in cancer, variants enriched and finally, understand their genomic language. Stat-genomics and ML/DL-AI tools will be implemented to cater to this goal.
Collaborative Projects with other labs to develop analysis pipelines and implement methods for single-cell/bulk deconvolution methods, raw sequencing data analysis (ATAC, ChIP, RNA, snRNA-seq) to understand experiment conditions in human/mouse samples.
Advisor: Dr. Ramana Davuluri, Professor, Biomedical Informatics, Stony Brook University, NY
Collaborators of Davuluri Lab I work with:
Dr. Paolo Boffetta, Associate Director for Population Sciences, Stony Brook Cancer Center
Dr. Nadia Dahmane, Associate Professor, Brain and Mind Research Institute, Cornell University
Dr. Yusuf Hannun, Director, Stony Brook Cancer Center, Stony Brook University
Dr. Daniela Matei, Professor, Obstetrics and Gynecology, Northwestern University
Dr. Puneet Opal, Professor of Neurology, Northwestern University
Computational Biology Co-Op
A Shiny interface for Tumor deconvolution methods to stratify patients using signature-based methods.
Built an elastic-net deconvolution approach to stratify patient immune cell types.
Manager: Dr. Dinesh Manandhar, Computational Biology, GlaxoSmithKline, Collegeville, PA
Master’s Thesis
Naturally occurring variants modify neurodevelopmental phenotypes.
A pilot 2-hit genetic screen using Drosophila melanogaster was used to study 16p11.2 chromosomal location genes by tracking changes in eye phenotypes.
Significant SNPs and sex-biased interactions reported by GWAS.
Advisor: Dr. Santhosh Girirajan, Professor, Genomics, Penn State University, PA
Undergraduate Research (06.18–06.19)
RBPs role in skeletal muscle development.
Data curation of RNA binding proteins (RBPs) related to muscle development in Drosophila melanogaster.
Further, tracked the skeletal muscle defects caused by RBPs using genetic knockdown experiments and behavioral assays.
Advisor: Dr. Upendra Nongthomba, Professor, Molecular Reproduction, Development and Genetics, Indian Institute of Science, India
Drug-design Research (09.17–04.18)
Analysis of non-synonymous mutations in XDR and MDR marketed tuberculosis drugs for drug resistance by their common mutation patterns using Pharmacophore mapping, Molecular docking and MD simulations.
Advisor: Dr. Mukta Sharma, CSIR-IGIB, India