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Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive decline. Despite worldwide efforts to find a cure, no proper treatment has been developed yet, and the only effective countermeasure is to prevent the disease progression by early diagnosis. The reason why new drug candidates fail to show therapeutic effects in clinical studies may be due to misunderstanding the cause of AD. Regarding the cause of AD, the most widely known is the amyloid cascade hypothesis, in which the deposition of amyloid beta and hyperphosphorylated tau is the cause. However, many new hypotheses were suggested. Among them, based on preclinical and clinical evidence supporting a connection between AD and diabetes, insulin resistance has been pointed out as an important factor in the development of AD. Therefore, by reviewing the pathophysiological background of brain metabolic insufficiency and insulin insufficiency leading to AD pathology, we will discuss how can insulin resistance cause AD. Read more here
Finland has the highest death rate from dementia in the world and its environmental features can be instructive in understanding hidden causes of dementia. Read more here
Based on the most recent estimates by the Canadian Cancer Society, 2 in 5 Canadians will develop cancer in their lifetimes. More than half of all cancer patients receive some type of radiation therapy, and all patients undergo radiation-based diagnostics. While radiation is one of the most important diagnostic and treatments modalities, high-dose cranial radiation therapy causes numerous central nervous system side-effects, including declines in cognitive function, memory, and attention. While the mechanisms of these effects have been studies, they still need to be further elucidated. On the other hand, the effects of low dose radiation as well as indirect radiation bystander effects on the brain remain elusive. Read more here
Several factors contribute to this phenomenon, from altered taste perception to the effects of blood sugar regulation. Understanding these connections can help families make informed choices about nutrition and care. Read more here
Evidence suggests that excessive consumption of sugary beverages, even in physically active individuals, is associated with metabolic problems including an increased risk of insulin resistance, type 2 diabetes, dyslipidemia (high triglycerides), and cardiovascular disease (CVD) . This risk persists regardless of high physical activity levels. Expand to read more
Key Metabolic Problems and Evidence
Insulin Resistance and Type 2 Diabetes: Regular high intake of sugar-sweetened beverages (SSBs) spikes blood glucose and insulin levels. Over time, this can lead to cellular insulin resistance and β-cell dysfunction, significantly increasing the risk for type 2 diabetes. One Harvard study found that even physically active individuals who consumed one sugary drink daily had an 18% higher risk of CVD.
Dyslipidemia (High Triglycerides and VLDL): The fructose component in sugary drinks is processed primarily by the liver in an unregulated manner. This leads to increased de novo lipogenesis (fat creation) and the production of very low-density lipoproteins (VLDL) and triglycerides, which are risk factors for cardiovascular disease. Studies on physically active males showed that 15 days of excessive SSB intake significantly increased triglycerides and VLDL levels.
Inflammation: High sugar intake has been linked to increased levels of inflammatory markers like C-reactive protein (hs-CRP) and adenosine deaminase (ADA) in semi-professional athletes. Chronic inflammation contributes to the development of metabolic and cardiovascular diseases.
Hepatic (Liver) Stress and Fatty Liver: The unregulated metabolism of excessive fructose can deplete liver cell ATP and promote the accumulation of visceral and ectopic fat. This puts individuals on the path to non-alcoholic fatty liver disease (NAFLD), a condition also associated with general excess calorie intake.
Increased Uric Acid: Fructose metabolism produces uric acid as a byproduct. Elevated uric acid levels (hyperuricemia) are a risk factor for gout, hypertension, and kidney disease, even after adjusting for body mass index (BMI).
Impact on Performance
Beyond long-term health risks, excessive sugar intake around workouts can impair immediate athletic performance:
"Sugar Crashes": Rapidly digested sugars can cause a quick burst of energy followed by a "crash" (fatigue, dizziness, irritability) as blood glucose levels drop, which reduces endurance.
Reduced Endurance and Oxygen Uptake: Studies found that excessive SSB intake over a short period decreased cardiorespiratory response to exercise (VO2max) and total exercise time, possibly due to reduced nitric oxide bioavailability and consequent poorer nutrient/oxygen flow to muscles.
Gastrointestinal (GI) Issues: High amounts of fructose, especially when consumed alone, can be poorly absorbed in the small intestine, leading to fermentation in the colon, which causes bloating, gas, and stomach pain during exercise.
In conclusion, while moderate, targeted sugar intake (e.g., in specific sports drinks during prolonged endurance exercise) can aid performance and recovery, excessive and regular consumption poses significant, well-documented metabolic health risks for athletes.
Summary provided by Gemini
Transformative justice (TJ) approaches to anti-racism focus on dismantling the systemic and structural causes of racial harm, such as white supremacy and colonialism, rather than simply addressing individual incidents or relying on the existing criminal justice system, which is often a source of racial injustice. Expand to read more
Core Principles of Transformative Justice in Anti-Racism
Addressing Root Causes: Transformative justice seeks to understand and address the underlying social conditions and structural injustices (poverty, lack of housing, inadequate education, etc.) that enable harm to occur, rather than focusing solely on individual wrongdoing.
Centering Impacted Communities: Approaches are survivor-centric and community-led, prioritizing the voices, experiences, and needs of those most affected by racism, particularly Black, Indigenous, and racialized communities.
Community Accountability: It emphasizes building community capacity to address harm and conflict internally, without relying on state systems like police or prisons, which disproportionately target marginalized groups.
Holistic Healing and Support: The focus is on facilitating healing, resilience, and safety for all involved (survivors and those who caused harm) by providing necessary resources like counselling, housing support, and other social services.
Systemic Transformation: The ultimate goal is not a return to a prior "just" state, but the creation of a new, more equitable system that does not reproduce violence and oppression.
Key Approaches in Practice
Decolonizing and Pluralizing Justice: This involves integrating diverse perspectives and knowledge systems, such as Afrocentric or Indigenous approaches, into justice frameworks to challenge dominant Western narratives and address legacies of colonialism and imperialism.
Policy and Legislative Reform: Transformative justice informs the development of comprehensive, intersectional anti-racism strategies and action plans that aim to amend laws and reform practices that have a disproportionate negative impact on racialized individuals.
Investing in Community-Led Solutions: Strategies include redirecting resources away from carceral systems and towards community-based initiatives, education, and social support systems that prevent harm from occurring in the first place.
Reparative Justice: This model, often intertwined with TJ, focuses on addressing and remedying large-scale historical injustices inflicted upon collective groups through actions like compensation, restoration, and formal apologies to foster healing and reconciliation.
Building Empathy and Understanding: TJ encourages open dialogue and awareness-raising to build empathy and understanding, fostering a culture of respect and accountability in various settings like workplaces and educational institutions.
By adopting transformative justice approaches, anti-racism work moves beyond individual blame and punishment to address the foundational inequities that allow racial harm to persist, fostering long-term, systemic change.
Summary provided by Gemini
How to maintain the hormonal nutrition and balance your brain needs