Embedded Files
Page 5
WHO case definition for HIV infection Adults and children 18 months or older HIV infection is diagnosed based on: positive HIV antibody testing (rapid or laboratory-based enzyme immunoassay). This is confirmed by a second HIV antibody test (rapid or laboratory-based enzyme immunoassay) relying on different antigens or of different operating characteristics; and/or; positive virological test for HIV or its components (HIV-RNA or HIV-DNA or ultrasensitive HIV p24 antigen) confirmed by a second virological test obtained from a separate determination. Children younger than 18 months: HIV infection is diagnosed based on: positive virological test for HIV or its components (HIV-RNA or HIV-DNA or ultrasensitive HIV p24 antigen) confirmed by a second virological test obtained from a separate determination taken more than four weeks after birth. Positive HIV antibody testing is not recommended for definitive or confirmatory diagnosis of HIV infection in children until 18 months of age.
Cases diagnosed with advanced HIV infection (including AIDS) not previously reported should be reported according to a standard case definition. Advanced HIV infection is diagnosed based on clinical and/or immunological (CD4) criteria among people with confirmed HIV infection (Box 2). Box 2. Criteria for diagnosis of advanced HIV (including AIDSa) for reporting Clinical criteria for diagnosis of advanced HIV in adults and children with confirmed HIV infection: presumptive or definitive diagnosis of any stage 3 or stage 4 condition. and/or; Immunological criteria for diagnosing advanced HIV in adults and children five years or older with confirmed HIV infection: CD4 count less than 350 per mm3 of blood in an HIV-infected adult or child. and/or; Immunological criteria for diagnosing advanced HIV in a child younger than five years of age with confirmed HIV infection: %CD4+ <30 among those younger than 12 months; %CD4+ <25 among those aged 12–35 months; %CD4+ <20 among those aged 36–59 months.
Report abuse