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Greetings
It is truly an honour for us to host OsakaMito2025 "The International Workshop on Metabolite Code and Cell Homeostasis", and we would like to extend a warm welcome to all participants of this special event. OsakaMito2025 targets the next generation of researchers, including graduate students, postdoctoral fellows and early-career principal investigators in the basic, medical and pharmacological fields of mitochondrial research. We are going to focus on how mitochondrial and cellular metabolism is regulated and contributes to cellular and individual health, together with the basic mechanisms for maintaining mitochondrial functions as metabolic hubs. Participants will gain new insights into the molecular basis of mitochondrial biology and their pathophysiological roles relevant to future therapeutic and pharmaceutical approaches. We will have almost 3 days focusing on the latest developments in mitochondrial research, as well as creating a close and core scientific community and friendships among us. The Osaka University Suita Campus is located in the northern part of Osaka, and is currently undergoing a massive renovation. Osaka is often referred to as "the kitchen of Japan", where you would enjoy delectable street food and local specialities. We are sure that you would enjoy Japanese traditions and cultural experiences in this city, and hope your stay in Osaka would be enjoyable.
Conference Description
In line with the above conference theme, Thomas Langer (EMBO Member) will kick off this workshop with the EMBO Keynote Lecture, showing the recent study on mitochondrial nucleotide metabolism and its impact on ageing and inflammation. Yilin Kang will present the role of the mitochondrial DNA maintenance system in antiviral defense and inflammation-related diseases. Hiromi Sesaki, Mike Ryan, Sho Aki, Yuki Hanada and Saori Yoshii will deliver presentations about basic mechanisms critical for mitochondrial dynamics and distribution, and how defects in these dynamics affect cellular metabolism and homeostasis. Noriyuki Matsuda, and Tadashi Yamamuro will lead us to dive deeply into how the disruption of mitochondrial metabolic pathways is associated with pathologies such as Parkinson's Disease and obesity. Tasneem Qaqorh will show us how we can integrate omics datasets to identify the drivers of mitochondrial diseases. Jared Rutter, Hans-Georg Sprenger, Ina Huppertz, and Yohsuke Ohba will propose novel mechanisms by which metabolites, RNA and lipid environments can actively regulate intrinsic cellular pathways. Additionally, Taki Nishimura will provide a newly-established tool to investigate the dynamic localization of lipid species in cells. Sae Tanaka will focus on tardigrade mitochondria to elucidate their tolerance mechanisms under metabolically challenging environments. Saori Shinoda will showcase whether and how nuclear-encoded RNAs can be imported into mitochondria in yeast. Kunio Nakatsukasa, Christian Münch, and Shiori Sekine, will share recent findings on how mitochondrial import pathways are regulated and stress response is triggered by impaired mitochondrial protein import. Mashun Onishi will demonstrate the role of mitochondrial stress response in resistance against glutathione depletion. The mitochondrial unfolded protein response, an another type of mitochondrial stress response, will further be in the spotlight by Ye Tian's presentation, together with its impact on lifespan extension. In addition, Keisuke Takeda will also focus on how mitochondria respond to the compartment-specific accumulation of protein aggregates. Hongyun Tang will provide a new insight in the quantity control system of mitochondria in C. elegans. Soni Deshwal and Natsuki Shinoda, will switch our gears to cell death by demonstrating how the dual localized proteins control vulnerability to different types of cell death: ferroptosis and apoptosis. Keiko Kono will focus on mitochondria-centric mechanisms in response to plasma membrane damage and their role in cellular senescence. Through these programs, we will cover both basic and novel areas, bringing them together and integrating them to broaden our understanding of the role and impact of mitochondria in cell homeostasis.
Organizers
Mashun Onishi
The University of Osaka, Japan
Dr. Mashun Onishi is an assistant professor at the Institute for Protein Research, The University of Osaka, Japan. He holds a bachelor's degree in life sciences from University of Hyogo, where he studied ER and Golgi stress responses under the supervision of Hiderou Yoshida. Driven by his interest in mitochondrial biology and their quantity and quality control system, he joined Koji Okamoto's lab in Osaka University, where he performed mechanistic studies on the role of mitophagy in cell homeostasis using yeast models. In 2020, he received a Ph.D. degree from Osaka University for studying ER-associated regulatory mechanisms of mitophagy. He then moved on to the Thomas Langer's lab at the Max Planck Institute in Germany, where he studied how mitochondrial retrograde stress signalling acts in modulating cell death. He has now joined Taki Nishimura's lab at the Institute for Protein Research, The University of Osaka, exploring how membrane lipid environments.
Saori Shinoda
University of Tokyo, Japan
Dr. Saori Shinoda is an Assistant Professor at the Institute for Quantitative Biosciences, The University of Tokyo, Japan. She received a bachelor's degree in 2013 from Tokyo Metropolitan University, followed by a master's degree in 2015 from The University of Tokyo, where she investigated post-transcriptional modifications of mitochondrial tRNA (with Tsutom Suzuki). In 2019, She holds a Ph.D. degree from The University of Tokyo, for studying the molecular mechanism of autophagy - in particular, how lysosomes can fuse with only completed autophagosomes (with Noboru Mizushima). Until 2024, she worked as apostdoctoral researcher at Kyoto Sangyo University, focusing on RNA import into mitochondria (with Toshiya Endo). She is continuing this work in her current position (with Yukihide Tomari). Her research focuses on the spatio-temporal roles of nucleic acids (RNA and DNA) in mitochondria.
Keisuke Takeda
The University of Osaka, Japan
Dr. Keisuke Takeda is an Assistant Professor at the Graduate School of Science, Department of Biological Sciences, The University of Osaka, Japan. He holds a Ph.D. degree in 2018 from Tokyo University of Pharmacy and Life Sciences, where he investigated the contribution of ER-mitochondria contacts to the ER stress responses. Until 2024, he worked at the University of Padova as a research fellow for exploring principles behind and consequences of intra-mitochondrial sorting and segregation against unfolded proteins (with Luca Scorrano). This project is still going on in his current position (with Naotada Ishihara). His current research interest is to identify a molecular basis to elicit protein gradient inside during mitochondrial fission for the removal of unfolded proteins.
Advisor
Koji Okamoto
Osaka University, Japan
Dr. Koji Okamoto is an Associate Professor at the Graduate School of Frontier Biosciences (FBS), Osaka University, Japan. After receiving a Ph.D. degree in 1995 from Hiroshima University and a decade abroad working on the transmission of mitochondrial DNA and proteins in zygotes (with Ronald Butow at UT Southwestern), the unfolding and translocation of mitochondrial preproteins (with Walter Neupert at the University of Munich), and mitochondrial dynamics (with Janet Shaw at the University of Utah), he went back to Japan and focused on mitophagy (with Yoshinori Ohsumi at the National Institute for Basic Biology and Tokyo Tech). In 2010, he was promoted as a principal investigator of the laboratory of mitochondrial dynamics at the FBS. His current research interests are to elucidate the crosstalk between mitochondria and autophagy in mitochondrial quality and quantity control pathways.
Contact
Mitochondria Young Working Group
jmit.ywg[at]gmail.com
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