Publications:

• • Liver Physiological maps:

Ladeira, L., Verhoeven, A., van Ertvelde, J., Jiang, J., Gamba, A., Sanz Serrano, J., Vanhaecke, T., Heusinkveld, H., Jover, R., Vinken, M., Geris, L., & Staumont, B. (2025). Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding. Frontiers in Toxicology, 7, 1619651. https://doi.org/10.3389/ftox.2025.1619651

• • Concept of physiological maps and workflow to build them:

Staumont, B., Ladeira, L., Gamba, A., Heusinkveld, H. J., Piersma, A., Fritsche, E., Masereeuw, R., Vanhaecke, T., Teunis, M., Luechtefeld, T., Hartung, T., Jover, R., Vinken, M., & Geris, L. (2025). Mapping physiology: a systems biology approach for the development of alternative methods in toxicology. ALTEX. https://doi.org/10.14573/altex.2412241.  

• Key ONTOX papers:

Vinken, M., Benfenati, E., Busquet, F., Castell, J., Clevert, D.-A., de Kok, T. M., Dirven, H., Fritsche, E., Geris, L., Gozalbes, R., Hartung, T., Jennen, D., Jover, R., Kandarova, H., Kramer, N., Krul, C., Luechtefeld, T., Masereeuw, R., Roggen, E., … Piersma, A. H. (2021). Safer chemicals using less animals: Kick-off of the European ONTOX project. Toxicology, 458, 152846. https://doi.org/10.1016/j.tox.2021.152846

All ONTOX publications can be found here: https://ontox-project.eu/scientificpapers/ 

• Probabilistic risk assessment workshop report

Maertens, A., Kincaid, B., Bridgeford, E., Brochot, C., de Carvalho e Silva, A., Dorne, J.-L. C. M., Geris, L., Husøy, T., Kleinstreuer, N., Ladeira, L. C. M., Middleton, A., Reynolds, J., Rodriguez, B., Roggen, E. L., Russo, G., Thayer, K., & Hartung, T. (2025). From cellular perturbation to probabilistic risk assessments. ALTEX - Alternatives to Animal Experimentation. https://doi.org/10.14573/altex.2501291 

• Comment on artificial intelligence in nephrotoxicology

Barnes, D.A., Ladeira, L. & Masereeuw, R. From big data to smart decisions: artificial intelligence in kidney risk assessment. Nat Rev Nephrol (2025). https://doi.org/10.1038/s41581-025-00962-1 

• Neural Tube Closure first version, published by Harm Heusinkveld and collaborators:

Heusinkveld, H. J., Staal, Y. C. M., Baker, N. C., Daston, G., Knudsen, T. B., & Piersma, A. (2021). An ontology for developmental processes and toxicities of neural tube closure. Reproductive Toxicology, 99, 160–167. https://doi.org/10.1016/j.reprotox.2020.09.002