Liver Bile Secretion Physiological Map
Embedded Files
The Liver Bile Secretion Physiological Map is constructed through the curation of literature evidence and pathway resources. A Physiological Map is a type of Disease Map focused on the underlying undisturbed physiological processes. This work is performed in close collaboration with domain experts. This map is being developed to study chemical-induced steatosis in the ONTOX project.
Navigate the interactive map on MINERVA.
Download the Liver Lipid Metabolism PM files.
Check the map documentation.
Curation and domain expert team:
Luiz Ladeira, PhD (Curator; Postdoctoral Researcher at the GIGA In Silico Medicine, University of Liège, Liège, Belgium);
Annika Drees (Domain expert; PhD Researcher at the Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium);
Julen Sans Serrano, PhD (Domain expert; Postdoctoral Researcher at the Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium);
Anouk Verhoeven (Domain expert; PhD Researcher at the Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium);
Bernard Staumont, PhD (Curator; Project Manager and Postdoctoral Researcher at the GIGA In Silico Medicine, University of Liège, Liège, Belgium);
Alessio Gamba, PhD (Curator; Postdoctoral Researcher at the GIGA In Silico Medicine, University of Liège, Liège, Belgium);
Ramiro Jover, PhD (Domain expert; Professor at Department of Biochemistry, University of Valencia, IIS Hosp. La Fe, CIBERehd, Spain);
Anna Rapisarda, PhD (Domain expert; Project Manager and Postdoctoral Researcher at Department of Biochemistry, University of Valencia, IIS Hosp. La Fe, CIBERehd, Spain);
Tamara Vanhaecke, PhD (Domain expert; Professor at the Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium);
Mathieu Vinken, PhD (Domain expert; ONTOX coordinator; Professor at the Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium);
Liesbet Geris, PhD (Curator team PI; ONTOX PMs task leader; Head of the Biomechanics Research Unit, Professor at University of Liège and KU Leuven, Belgium).
Former contributors:
Jian Jiang, PhD (Domain expert);
Jonas van Ertvelde (Domain expert).
How to cite:
Ladeira, L., Verhoeven, A., van Ertvelde, J., Jiang, J., Gamba, A., Sanz Serrano, J., Vanhaecke, T., Heusinkveld, H., Jover, R., Vinken, M., Geris, L., & Staumont, B. (2025). Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding. Frontiers in Toxicology, 7, 1619651. https://doi.org/10.3389/ftox.2025.1619651
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