*A) "An Integrated Workflow for Exosome Capture, Recognition-Guided Proximity Labeling of Surface Proteins, and Release"
Yoshihiro Ueda, Yoshiyuki Manabe, Sayoko Saito, Kanae Sano, Yuka Furukawa, Hiroaki Tateno*, Kounosuke Oisaki*
Submitted.
［Preprint: ChemRxiv 2026, DOI: 10.26434/chemrxiv.15000154/v2］
*B) "Mechanochemical C‑Terminal Activation of Peptides: Solvent‑Minimal Thiocarboxylation with Suppressed Epimerization"
Kounosuke Oisaki*, Hiroshi Igarashi, Koki Fujimura, Masahiro Hayashi, Masato Nakano
Submitted.
［Preprint: ChemRxiv 2026, DOI: 10.26434/chemrxiv.15006081/v1］
*C) "Synthetic Mutagenesis of Tyrosine into Proline Mimetics Enables Late-Stage Backbone Editing of Peptides"
Takaya Togo, Takumi Ueda, Yuko Otani, Yuka Furukawa, Kohei Nogita, Katsuya Maruyama, Koh Takeuchi, Motomu Kanai*, Kounosuke Oisaki*
Submitted.
［Preprint: ChemRxiv 2026, DOI: 10.26434/chemrxiv.15008909/v2］
*51) "Material-Efficient Optimization of Peptide Bioconjugation via Sub-Micromole Automated Flow and Bayesian Optimization"
Yuki Fujii, Takayuki Doi, Yoshihiro Ueda, Akira Yada, Kounosuke Oisaki,* Kanako Nozawa-Kumada*
Synlett 2026, e-First. DOI:10.1055/a-2942-7756
〈Invited contribution on Prof. Masakatsu Shibasaki's 80th birthday〉
*50) "Electrochemical tryptophan-selective bioconjugation in neutral buffer via cooperative N‑oxyl radicals"
Ryo Kuroda‡, Eisho Toyama‡, Moe Toyobe, Tomoya Sugai, Maho Imai, Kohei Watanabe, Natsuki Konoue, Katsuya Maruyama, Yuka Furukawa, Masahiro Hayashi, Mio Kondo, Shigeyuki Masaoka, Tsuyoshi Saitoh, Kounosuke Oisaki*, Motomu Kanai* [‡equally contributed]
Bioconjugate Chem. 2026, 37, 1367-1376. DOI: 10.1021/acs.bioconjchem.6c00084
［Preprint: ChemRxiv 2026, DOI: 10.26434/chemrxiv-2025-s1wv9/v4］
〈Highlighted by Supplementary Cover〉
49) "Toward N-Linked Glycoproteins: Three-Step Synthesis of Glycan-Asparagine Conjugates from Unprotected Sugars"
Junya Akeno, Kiyosei Takasu, Kounosuke Oisaki, Kanako Nozawa-Kumada, Takeshi Nanjo, Norihisa Fukaya, Yoshihiro Ueda*
Org. Lett. 2026, 28 (11), 3441-3447. DOI:10.1021/acs.orglett.6c00314
〈Highlighted by Supplementary Cover, SYNFACTS 2026, 22, 570〉
48) "Electrochemical Regeneration of Tetramethyl Orthosilicate from Hexamethoxydisiloxane"
Tomoya Sugai, Katsuhiko Takeuchi, Kounosuke Oisaki, Norihisa Fukaya, Jun-Chol Choi*, Tsuyoshi Saitoh*
ChemElectroChem 2026, 13(1), e202500378. DOI:10.1002/celc.202500378
〈Highlighted by Front Cover〉
*47) "Practical N-to-C Peptide Synthesis with Minimal Protecting Groups"
Toshifumi Tatsumi, Koki Sasamoto, Takuya Matsumoto, Ryo Hirano, Kazuki Oikawa, Masato Nakano, Masaru Yoshida, Kounosuke Oisaki*, Motomu Kanai*
Commun. Chem. 2023, 6, 231. doi: 10.1038/s42004-023-01030-0
［Preprint: Research Square 2023, doi: 10.21203/rs.3.rs-3138792/v1］
〈Press release from AIST〉
〈Highlighted by PR TIMES、 日経新聞オンライン、読売新聞オンライン、日刊工業新聞(2023/11/1)、Pharm Tech Japan Online、Tii技術情報、文教速報デジタル版、Chem-Station、FUJIFILM Finechemical News、Synfacts of the month〉
*46) "Bioconjugation of Electron-Probe Au25 Nanocluster to Monoclonal Antibody at Tryptophan"
Katarzyna Joanna Malawska, Shinjiro Takano, Kounosuke Oisaki*, Haruaki Yanagisawa, Tatsuya Tsukuda, Masahide Kikkawa, Motomu Kanai*
Bioconjugate Chem. 2023, 34(4), 781-788. doi: 10.1021/acs.bioconjchem.3c00069.
［Preprint: ChemRxiv 2022, DOI:10.26434/chemrxiv-2022-993zl］
*45) "A Germanium Catalyst Accelerates the Photoredox α-C(sp3)–H Alkylation of Primary Amines"
Kentaro Sakai, Kounosuke Oisaki*, Motomu Kanai*
Org. Lett. 2022, 24(18), 3325–3330. doi: 10.1021/acs.orglett.2c00871.
〈Ranked in Most Accessed Articles of Org. Lett. in May 2022〉
〈Highlighted by Org. Chem. Highlights 2022, October 17., Organic Chemistry Portal〉
44) "Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity"
Takaaki Tatsuguchi†, Takehito Uruno†*, Yuki Sugiura, Kounosuke Oisaki, Daisuke Takaya, Daiji Sakata, Yoshihiro Izumi, Takaya Togo, Yuko Hattori, Kazufumi Kunimura, Tetsuya Sakurai, Teruki Homma, Takeshi Bamba, Masafumi Nakamura, Motomu Kanai, Makoto Suematsu, Yoshinori Fukui* [† equally contributed]
Biochem. Biophys. Res. Commun. 2022, 609, 183-188. doi:10.1016/j.bbrc.2022.04.035
*43) "Protein Modification at Tyrosine with Iminoxyl Radicals"
Katsuya Maruyama, Takashi Ishiyama, Yohei Seki, Kentaro Sakai, Takaya Togo, Kounosuke Oisaki*, Motomu Kanai*
J. Am. Chem. Soc. 2021, 143(47), 19844–19855. DOI: 10.1021/jacs.1c09066
［Preprint: ChemRxiv 2021 DOI: 10.33774/chemrxiv-2021-m73zv-v2］
〈Press release from UT, highlighted by Chem-Station, Faculty Opinions 〉
42) "Targeted inhibitor of EPAS1-driven IL-31 production by a small-molecule compound"
Yasuhisa Kamikaseda, Takehito Uruno, Kazufumi Kunimura, Akihito Harada, Kuniko Saiki, Kounosuke Oisaki, Daiji Sakata, Takeshi Nakahara, Makiko Kido-Nakahara, Motomu Kanai, Seiji Nakamura, Yasuyuki Ohkawa, Masutaka Furue, Yoshinori Fukui*
J. Allergy Clin. Immunol. 2021, 148(2), 633-638. DOI: 10.1016/j.jaci.2021.03.029
〈Press release from KU, highlighted by 財経新聞, QLifePro, マイナビニュース〉
*41) "A Bond-weakening Borinate Catalyst that Improves the Scope in the Photoredox α-C–H Alkylation of Alcohols"
Kentaro Sakai, Kounosuke Oisaki*, Motomu Kanai*
Synthesis 2020, 52(15), 2171-2189. DOI: 10.1055/s-0040-1707114
〈Invited contribution honoring Thieme Chemistry Journals Award〉
〈Selected as The Best Paper Award 2020 in Synthesis〉
〈Highlighted by Synform〉
*40) "Induction of ADCC by folic acid-mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer"
Hiroshi Tagawa†, Katsuya Maruyama†, Koichi Sasaki, Natsuki Konoue, Motomu Kanai, Takeshi Mori*, Kounosuke Oisaki*, Yoshiki Katayama* [† equally contributed]
RSC Adv. 2020, 10, 16727-16731. DOI: 10.1039/D0RA03291C (Open Access)
*39) "Synthesis of Tryptophan-Folate Conjugates"
Katsuya Maruyama, Katarzyna Joanna Malawska, Natsuki Konoue, Kounosuke Oisaki*, Motomu Kanai*
Synlett 2020, 31 (08), 784-787. DOI: 10.1055/s-0039-1691735
*38) "Identification of Bond-Weakening Spirosilane Catalyst for Photoredox α−C–H Alkylation of Alcohols"
Kentaro Sakai, Kounosuke Oisaki*, Motomu Kanai*
Adv. Synth. Catal. 2020, 362(2), 337-343. doi: 10.1002/adsc.201901253
〈Invited contribution to Eric N. Jacobsen's 60th birthday special issue〉
〈Ranked in Most Accessed Articles (5/2019-4/2020) of Adv. Synth. Catal.〉
〈Ranked in Top 10 Most Downloaded Articles of Adv. Synth. Catal. during first 12 months〉
37) "Catalytic, Regio- and Enantio-Selective Proton Migration from Skipped Enynes to Allenes"
Xiao-Feng Wei, Takayuki Wakaki, Taisuke Itoh, Hong-Liang Li, Takayshi Yoshimura, Aya Miyazaki, Kounosuke Oisaki, Miho Hatanaka*, Youhei Shimizu*, Motomu Kanai*
Chem 2019, 5(3), 585-599. DOI: 10.1016/j.chempr.2018.11.022
〈Press release from UT〉
36) "Convergent and Functional-Group Tolerant Synthesis of B-Organo BODIPYs"
Taka Sawazaki, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma*, Motomu Kanai*
Org. Lett. 2018, 20(24), 7767-7770. DOI: 10.1021/acs.orglett.8b03138
*35) "A Catalytic One-step Synthesis of Peptide Thioacids: The Synthesis of Leuprorelin via Iterative Peptide-fragment Coupling Reactions"
Takuya Matsumoto, Koki Sasamoto, Ryo Hirano, Kounosuke Oisaki*, Motomu Kanai*
Chem. Commun. 2018, 54, 12222-12225. doi: 10.1039/C8CC07935H
〈Highlighted by Synfacts 2019, 15, 201; Org. Chem. Highlights, 2019, May 13th〉
*34) "C(sp3)‒H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis"
Takayuki Wakaki, Kentaro Sakai, Takafumi Enomoto, Mio Kondo, Shigeyuki Masaoka, Kounosuke Oisaki*, Motomu Kanai*
Chem. Eur. J. 2018, 24(32), 8051-8055. doi: 10.1002/chem.201801746
〈Highlighted by Hot Topic: C-H Activation, Inside Cover〉
〈Ranked in Most Accessed Articles (11/2017 to 10/2018) of Chem. Eur. J.〉
*33) "Organophotoredox/Copper Hybrid Catalysis for Regioselective Allylic Aminodecarboxylation of β,γ-Unsaturated Carboxylic Acids"
Anne-Doriane Manick, Hirotaka Tanaka, Kounosuke Oisaki*, Motomu Kanai*
Synthesis 2018, 50(15), 2936-2947. DOI: 10.1055/s-0036-1591983
〈Invited contribution to Special Issue "Modern Radical Methods and their Strategic Applications in Synthesis" 〉
32) "DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation"
Takahiro Tomino, Hirotada Tajiri, Takaaki Tatsuguchi, Takahiro Shirai, Kounosuke Oisaki, Shigeki Matsunaga, Fumiyuki Sanematsu, Daiji Sakata, Tomoharu Yoshizumi, Yoshihiko Maehara, Motomu Kanai, Jean-François Cote, Yoshinori Fukui, Takehito Uruno*
Biochem. Biophys. Res. Commun. 2018, 497(1), 298-304. DOI:10.1016/j.bbrc.2018.02.073 (Open Access)
*31) "Sulfonamides as new hydrogen atom transfer (HAT) catalysts for photoredox allylic and benzylic C−H arylations"
Hirotaka Tanaka, Kentaro Sakai, Atsushi Kawamura, Kounosuke Oisaki*, Motomu Kanai*
Chem. Commun. 2018, 54, 3215-3218. DOI: 10.1039/C7CC09457D
〈Selected as Back Cover〉
〈Highlighted by Organic Chemistry Portal〉
30) "Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1"
Hirotaka Tajiri†, Takehito Uruno†, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga, Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto-Niino, Kounosuke Oisaki, Miho Ushijima, Fumiyuki Sanematsu, Teruki Honma, Takaho Terada, Eiji Oki, Senji Shiarasawa, Yoshihiko Maehara, Dongchon Kang, Jean-François Côté, Shigeyuki Yokoyama, Motomu Kanai, Yoshinori Fukui* [†equally contributed]
Cell Reports 2017, 19(5), 969-980. doi: 10.1016/j.celrep.2017.04.016 (Open Access)
〈Highlighted by press release, 西日本新聞〉
*29) "Ligand-free, copper-catalyzed aerobic benzylic sp3 C-H oxygenation"
Hirotaka Tanaka, Kounosuke Oisaki*, Motomu Kanai*
Synlett 2017, 28, 1576-1580. DOI: 10.1055/s-0036-1588969
〈Invited contribution to "Aerobic Oxidation" cluster〉
*28) "Transition metal-free tryptophan-selective bioconjugation of proteins"
Yohei Seki, Takashi Ishiyama, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki*, Motomu Kanai*
J. Am. Chem. Soc. 2016, 138(34), 10798-10801. doi:10.1021/jacs.6b06692
〈Highlighted by UT press release, Department News, QLifePro, Chem-Station, 科学新聞(2016/8/26), UCR Proposal〉
27) "Switchable photooxygenation catalysts that sense higher-order amyloid structures"
Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma*, Motomu Kanai*
Nat. Chem. 2016, 8, 974-982. doi:10.1038/nchem.2550
〈Highlighted by JST press release, 認知症ねっと, 薬事日報(2016/7/11), Chem-Station〉
*26) "Enhanced structural variety of nonplanar N-oxyl radical catalysts and their application to the aerobic oxidation of benzylic C-H bonds"
Yoichi Kadoh, Kounosuke Oisaki*, Motomu Kanai*
Chem. Pharm. Bull. 2016, 64, 737-753. DOI: 10.1248/cpb.c16-00083
〈Invited contribution in honor of Nobel Prize laureate, Prof. Satoshi Ōmura〉
*25) "Directing activator-assisted regio- and oxidation state-selective aerobic oxidation of secondary C(sp3)–H bonds in aliphatic alcohols"
Jizhi Ni, Jun Ozawa, Kounosuke Oisaki*, Motomu Kanai*
Org. Biomol. Chem. 2016, 14, 4378-4381. DOI: 10.1039/c6ob00678g
〈Selected as 'Hot Articles' in Org. Biomol. Chem.〉
*24) "Chemo- and Regioselective Oxygenation of C(sp3)-H Bonds in Aliphatic Alcohols Using a Covalently Bound Directing Activator and Atmospheric Oxygen"
Jun Ozawa†, Masayuki Tashiro†, Jizhi Ni†, Kounosuke Oisaki*, Motomu Kanai* [†equally contributed ]
Chem. Sci. 2016, 7, 1904-1909. DOI: 10.1039/C5SC04476F (Open Access)
*23) "Organocatalytic aerobic oxidation of α-fluoroalkyl alcohols to fluoroalkyl ketones at room temperature"
Yoichi Kadoh, Masayuki Tashiro, Kounosuke Oisaki*, Motomu Kanai*
Adv. Synth. Catal. 2015, 357(10), 2193-2198. DOI: 10.1002/adsc.201500131
〈Invited contribution in honor of Stephen L. Buchwald's 60th birthday.〉
〈Ranked in Most Read Articles (2015/July) of Adv. Synth. Catal.〉
*22) "Metal-free C(3)-H arylation of coumarins promoted by catalytic amounts of 5,10,15,20-tetrakis(4-diethylaminophenyl)porphyrin"
Masahiro Kojima, Kounosuke Oisaki*, Motomu Kanai*
Chem. Commun. 2015, 51, 9718-9721. DOI: 10.1039/C5CC02349A
*21) "Chemoselective aerobic photo-oxidation of 9H-fluorenes for the synthesis of 9-fluorenones"
Masahiro Kojima, Kounosuke Oisaki*, Motomu Kanai*
Tetrahedron Lett. 2014, 55(34), 4736-4738. DOI: 10.1016/j.tetlet.2014.06.038
*20) "Serine-selective aerobic cleavage of peptides and a protein using water-soluble copper-organoradical conjugate"
Yohei Seki, Kana Tanabe, Daisuke Sasaki, Youhei Sohma, Kounosuke Oisaki*, Motomu Kanai*
Angew. Chem. Int. Ed. 2014, 53(25), 6501-6505. DOI: 10.1002/anie.201402618
〈Highlighted in Chem-Station Int. Ed., Org. Chem. Highlights 2015, March 9.〉
19) "Asparagine-selective cleavage of peptide bonds through hypervalent iodine-mediated Hofmann rearrangement in neutral aqueous solution"
Kana Tanabe, Atsuhiko Taniguchi, Takuya Matsumoto, Kounosuke Oisaki, Youhei Sohma*, Motomu Kanai*
Chem. Sci. 2014, 5, 2747-2753. DOI: 10.1039/C3SC53037J
〈Ranked in Top-Ten Most Downloaded Articles (2014/March) of Chem. Sci.〉
*18) "Manganese-catalyzed aerobic dehydrogenative cyclization toward ring-fused indole skeletons"
Kounosuke Oisaki*, Junpei Abe, Motomu Kanai*
Org. Biomol. Chem. 2013, 11(28), 4569-4572. DOI: 10.1039/C3OB40855H (invited article)
*17) "Iron-catalyzed oxidative C(3)-H functionalization of amines"
Noriaki Takasu, Kounosuke Oisaki*, Motomu Kanai*
Org. Lett. 2013, 15(8), 1918–1921. doi: 10.1021/ol400568u
〈Ranked in Monthly Most Read Articles (2013/April) of Org. Lett.〉
〈Featured in Org. Chem. Highlights 2014, March 24, ChemInform 2013, 44(35)〉
*16) "Catalytic aerobic production of imines en route to mild, green, and concise derivatization of amines"
Toshiaki Sonobe, Kounosuke Oisaki*, Motomu Kanai*
Chem. Sci. 2012, 3, 3249-3255. DOI: 10.1039/C2SC20699D
〈Ranked in Top-Ten Most Accessed Articles (2012/August) of Chem. Sci.〉
〈Featured in Yakuji Nippo (3/22/2013)〉
〈keto-ABNO is commercialized by Wako Pure Chemical Industries, Ltd.: 016-25001 (100 mg) / 012-25003 (1 g); Merck: 791815-250MG / 1G; featured in Wako Chemicals' leaflet〉
*15) "Functional group-tolerant catalytic migratory oxidative coupling of nitrones"
Shogo Hashizume, Kounosuke Oisaki*, Motomu Kanai*
Chem. Asian J. 2012, 7(11), 2600–2606. DOI: 10.1002/asia.201200359
〈Selected as the Cover Picture〉
*14) "Catalytic migratory oxidative coupling of nitrones"
Shogo Hashizume, Kounosuke Oisaki*, Motomu Kanai*
Org. Lett. 2011, 13(16), 4288-4291. DOI: 10.1021/ol201629n
13) "Crystalline covalent organic frameworks with hydrazone linkages"
Fernando Javier Uribe-Romo, Christian J. Doonan, Hiroyasu Furukawa, Kounosuke Oisaki, Omar M. Yaghi*
J. Am. Chem. Soc. 2011, 133(30), 11478-11481. DOI: 10.1021/ja204728y
〈Ranked in Most Read Articles (2011/July) of J. Am. Chem. Soc.〉
*12) "A metal-organic framework with covalently bound organometallic complexes"
Kounosuke Oisaki*, Qiaowei Li, Hiroyasu Furukawa, Alexander U. Czaja, Omar M. Yaghi*
J. Am. Chem. Soc. 2010, 132(27), 9262-9264. DOI: 10.1021/ja103016y
11) "Identification of modular chiral bisphosphines effective for Cu(I)-catalyzed asymmetric allylation and propargylation of ketones"
Shi-Liang Shi, Li-Wen Xu, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2010, 132(19), 6638-6639. DOI: 10.1021/ja101948s
10) "Asymmetric reductive Mannich reaction to ketimines catalyzed by a Cu(I) complex"
Yao Du, Li-Wen Xu, Youhei Shimizu, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2008, 130(48), 16146-16147. DOI: 10.1021/ja8069727
〈This paper is featured in SYNFACTS 2009, 2, 177. 〉
9) "Cu(I)-catalyzed hetero-Diels-Alder reaction between Danishefsky-type siloxy dienes and ketones"
I-Hon Chen, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
Org. Lett. 2008, 10(22), 5151-5154. DOI: 10.1021/ol802134a
〈This paper is featured in SYNFACTS 2009, 2, 176.〉
8) "Catalytic enantioselective alkylative aldol reaction: efficient multicomponent assembly of dialkylzincs, allenic esters, and ketones toward highly functionalized δ-lactones with tetrasubstituted chiral centers"
Kounosuke Oisaki, Dongbo Zhao, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2007, 129(23), 7439-7443. DOI: 10.1021/ja071512h
〈This paper is featured in SYNFACTS 2007, 9, 967.〉
7) "Dramatic ligand effect on catalytic asymmetric reductive aldol reaction of allenic esters to ketones"
Dongbo Zhao, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2006, 128(45), 14440-14441. DOI: 10.1021/ja0652565
〈This paper is featured in SYNFACTS 2007, 2, 171.〉
6) "Catalytic enantioselective allylation of ketoimines"
Reiko Wada, Tomoyuki Shibuguchi, Sae Makino, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2006, 128(23), 7687-7691. DOI: 10.1021/ja061510h
5) "Catalytic enantioselective aldol reaction to ketones"
Kounosuke Oisaki, Dongbo Zhao, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2006, 128(22), 7164-7165. DOI: 10.1021/ja061815w
〈This paper is featured in SYNFACTS 2006, 9, 916.〉
4) "Catalytic enantioselective intermolecular reductive aldol reaction to ketones"
Dongbo Zhao, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
Tetrahedron Lett. 2006, 47(9), 1403-1407. doi:10.1016/j.tetlet.2005.12.097
〈This paper is featured in SYNFACTS 2006, 5, 472.〉
〈Ranked as No.15 in Top25 Hottest Articles (2006/Jan-Mar) of Tetrahedron Lett.〉
3) "New chiral bis(diphenylphospholane) ligands: design, synthesis, and application to catalytic enantioselective aldol reaction to ketones"
Kounosuke Oisaki, Dongbo Zhao, Yutaka Suto, Motomu Kanai*, Masakatsu Shibasaki*
Tetrahedron Lett. 2005, 46(25), 4325-4329. doi:10.1016/j.tetlet.2005.04.084
2) "Catalytic enantioselective allylboration of ketones"
Reiko Wada, Kounosuke Oisaki, Motomu Kanai*, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2004, 126(29), 8910-8911. DOI: 10.1021/ja047200l
1) "A new method for the catalytic aldol reaction to ketones"
Kounosuke Oisaki, Yutaka Suto, Motomu Kanai, Masakatsu Shibasaki*
J. Am. Chem. Soc. 2003, 125(19), 5644-5645. doi: 10.1021/ja034993n
*27) Kohei Nogita, Kenta Yokoi*, Kounosuke Oisaki* "Site-Selective Chemical Modification of Enzymes: Tools for Functional Tuning of Sustainable Biocatalysis"
Curr. Opin. Green Sust. Chem. 2026, 62, 101097. DOI: 10.1016/j.cogsc.2026.101097 (Invited Review)
*26) 生長幸之助* 「逆伸長でペプチド量産 ～コストと廃棄物を削減～」
日刊工業新聞（全国版） 2026年2月26日、 31頁（Japanese Account)
*25) Abhishek Tiwatane, Prakash Y. Khandave, Sampada Kulkarni, Kounosuke Oisaki*, Abhay H. Pande* "Chemotherapeutic drug - Antibody Conjugates (ChemoBodies): Recent Advances and Future Directions"
Curr. Oncol. Rep. 2025, 27, 1287-1311. doi:10.1007/s11912-025-01713-y (Review)
24) Seiya Ishizawa, Koki Fujimura, Kounosuke Oisaki, Shin-ichi Sato, Jun Ohata* "Catalysis in Chemical Modification of Proteins"
ChemCatChem 2025, 17(11), e202402125. doi: 10.1002/cctc.202402125 (Review)
［Preprint: ChemRxiv 2024, doi: 10.26434/chemrxiv-2024-jxph9］
*23) 生長幸之助* 「計画的偶発性マインドがもたらした研究キャリア」
有機合成化学協会誌 2023, 81(4), 366-380. doi: 10.5059/yukigoseikyokaishi.81.366 （Japanese Essay) [PDF]
22) 金井求*、生長幸之助、豊邉萌 「レドックス活性を利用した抗体修飾と応用」
MEDCHEM NEWS 2023, 33(1), 33-37. doi: 10.14894/medchem.33.1_33 （Japanese Account)
21) 生長 幸之助（取材協力） 「2022年ノーベル化学賞『クリックケミストリー』とは？～科学の目でみる、社会が注目する本当の理由」
産総研マガジン, 2023年1月25日 [URL]
*20) 生長幸之助*、浅野圭佑、上田善弘 「有機触媒探索からの計画的セレンディピティ」
医学のあゆみ 2022, 282(9), 23261-23263.（Japanese Essay) [Repository URL]
*19) 生長幸之助* 「技術の力で（出版の）限界を乗り越える」
ファルマシア、2021年5月号、409頁 doi: 10.14894/faruawpsj.57.5_409_1（Japanese Essay)
*18) 生長幸之助*、金井求* 「低反応性アミノ酸を標的とするタンパク質生体共役反応」
「ペプチド創薬の最前線」 監修：木曽良明、シーエムシー出版、第3章, 2019 (Japanese Book Chapter)
*17) Kounosuke Oisaki* "Development of Highly Chemoselective Oxidative Transformations by Designing Organoradicals"
Chem. Pharm. Bull. 2018, 66(10), 907-919. doi: 10.1248/cpb.c18-00501 (Invited Award Account)
〈Highlighted by Cover Picture, Featured Article〉
*16) Kentaro Sakai, Kounosuke Oisaki*, Motomu Kanai* "9-Azabicyclo[3.3.1]nonan-3-one N-oxyl (keto-ABNO)"
Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS), doi: 10.1002/047084289X.rn02235 (Research Account)
*15) 生長幸之助 「有機ラジカルを用いたタンパク質変換法の開発―実験的観察とコラボが紡ぎ出す開発ストーリー」
化学と工業, 2018, 71(7), 605-606. (Japanese Account)
*14) 生長幸之助 「均質な抗体―薬物複合体とその製造法」
化学と教育, 2018, 66(5), 236-237. (Japanese Account)
*13) 関陽平、田辺佳奈、佐々木大輔、相馬洋平、生長幸之助*、金井求* 「セリン選択的ペプチド鎖切断法」
Chemistry & Biology, 2017, 10(1), 6. (Japanese Account)
12) Takayuki Wakaki, Kounosuke Oisaki, Motomu Kanai* "Elementary and systemic views of the generation of toxic substances"
Green Chem. 2016, 18, 3681-3683. doi:10.1039/C6GC90058E (Essay)
11) Atsuhiko Taniguchi, Yusuke Shimizu, Jizhi Ni, Kounosuke Oisaki, Yoichiro Kuninobu, Youhei Sohma*, Motomu Kanai* "Development of selective photooxygenation catalyst targeting Amyloid-β"
Peptide Science 2015, 52, 215-216.
10) Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma*, Motomu Kanai* "Amyloid-selective oxygenation by photo-catalyst"
Peptide Science 2014, 51, 69-70.
*9) Yohei Seki, Kounosuke Oisaki*, Motomu Kanai* "Chemoselective Aerobic Oxidation Catalyzed by a Metal/Stable Organoradical Redox Conjugate"
Tetrahedron Lett. 2014, 55(28), 3738-3746. DOI: 10.1016/j.tetlet.2014.05.085 (Review, Open Access)
*8) 生長幸之助*、園部敏亮、金井求* 「アミンの穏和な酸素酸化反応および環境調和型酸化カップリングを進行させる銅/keto-ABNO触媒系」
和光純薬時報, 2014, 82(2), 2-5. (Japanese Account) [PDF]
*7) 生長幸之助* 「「ブログ」は合成化学研究をどう変えるか」
有機合成化学協会誌, 2014, 72(1), 74-78. DOI: 10.5059/yukigoseikyokaishi.72.74 (Japanese Essay)
6) 金井求*、松永茂樹、生長幸之助、清水洋平 「金属触媒固有の特性を活かした炭素-炭素結合形成反応を目指して：塩基触媒からレドックス活性触媒へ」
有機合成化学協会誌, 2013, 71(5), 433-442. DOI: 10.5059/yukigoseikyokaishi.71.433 (Japanese Account)
*5) 生長幸之助* 「二酸化炭素をメタノールに！カスケード触媒戦略が可能にした高難度反応」
化学、2012年9月号、63-64頁 (Japanese Account)
*4) Shogo Hashizume, Kounosuke Oisaki*, Motomu Kanai* "Catalytic Migratory Oxidative Coupling of Nitrones through an Outer-Sphere C(sp3)-H Activation Process"
The Chemical Record, 2011, 11(5), 236-241. DOI: 10.1002/tcr.201100024 (Research Account for MBLA Special Issue)
*3) 生長幸之助* 「硫黄イリドの新しい調製法」
ファルマシア、2011年5月号、437-438頁（Japanese Account)
*2) 生長幸之助* 「異質で多様な研究環境で過ごす意義―米国UCLA Yaghi研究室」
現代化学、2010年8月号、57-61頁 (Japanese Essay)
1) 柴﨑正勝*、金井求、生長幸之助 「四置換炭素の触媒的不斉構築法の開発と展開」
科学と工業、2007年7月号、314-321頁 (Japanese Account)
20) 舘野浩章、生長幸之助、礒田博子
「医薬組成物及びその製造方法」
特願2026-225116
出願者：国立研究開発法人 産業技術総合研究所、出願日：2026/10/15
19) 上田善弘、生長幸之助、舘野浩章
「ホスファチジルセリン結合分子－触媒複合体、複合体結合細胞外小胞、及び細胞外小胞のラベル化方法」
特願2026-183171
出願者：国立研究開発法人 産業技術総合研究所、出願日：2026/8/3
18) 礒田博子、Aktar Sharmin、生長幸之助、富永健一、畑中雅隆
「ミクログリア介在性神経炎症の予防又は治療剤、およびその使用」
特願2026-120744
出願者：国立研究開発法人 産業技術総合研究所、出願日：2026/6/26
17) 生長幸之助、野北康平、金井求、藤後貴也、上田卓見
「プロリン模倣骨格含有ペプチド、プロリン模倣骨格含有ペプチドの製造方法」
特願2026-077541
出願者：国立研究開発法人 産業技術総合研究所・国立大学法人 東京大学、出願日：2026/5/1
16) 中塚和希、洪達超、大山晃平、藤沼尚洋、井川博之、竹内勝彦、生長幸之助、崔準哲、須貝智也、斉藤毅
「エステル化触媒、及びエステルの製造方法」
特願2026-058314
出願者：国立研究開発法人 産業技術総合研究所・積水化学工業株式会社・国立大学法人 筑波大学
出願日：2026/3/31
15) 生長幸之助、中野眞人、西尾幸也
「ペプチド製造に用いられるタグ又はタグ形成用化合物、及びタグを用いるペプチド製造方法」
特願2026-049199
出願者：国立研究開発法人産業技術総合研究所、出願日：2026/3/24
14) 生長幸之助
「チオカルボン酸の合成方法」
特願2026-012997
出願者：国立研究開発法人産業技術総合研究所、出願日：2026/01/29
13) 谷口剛史、岡明里、下山祥弘、生長幸之助、崔準哲、佐々木崇、清水湧太郎
「炭化水素の製造方法」
特願2025-281579
出願者：国立研究開発法人産業技術総合研究所・株式会社日油、出願日：2026/1/7
12) 竹内勝彦、生長幸之助、今野英雄、富永健一
「イミド変性レブリン酸エステルの製造方法及び５－アミノレブリン酸又はその塩の製造方法」
特願2025-153533
出願者：国立研究開発法人産業技術総合研究所、出願日：2025/09/16
11) 上田善弘、生長幸之助、舘野浩章
「表面ラベル化細胞外小胞、細胞外小胞表面ラベル化試薬及び細胞外小胞の選択的ラベル化方法」
特願2025-016646
出願者：国立研究開発法人産業技術総合研究所、出願日：2025/02/04
10) 崔準哲、生長幸之助、竹内勝彦、深谷訓久、須貝智也、斉藤毅
「アルコキシモノシラン化合物の製造方法」
特願2024-195964
出願者：国立研究開発法人産業技術総合研究所・国立大学法人 筑波大学、出願日：2024/11/8
9) Yoshinori Fukui, Takehito Uruno, Koki Honma, Daisuke Takaya, Motomu Kanai, Kounosuke Oisaki, Takaya Togo, Yuki Sugiura
"Pharmaceutical composition having anti-cancer immunostimulating effect and/or immune checkpoint inhibition potentiating effect"
Filed Patents: WO2023068376 (A1); US20250002526 (A1); EP4420666(A1); JP2023554768(A)
出願者：国立大学法人九州大学・国立研究開発法人理化学研究所・国立大学法人東京大学・慶應義塾大学、公開日（WO）：2023/4/27 [Google Patent]
8) Yoshinori Fukui, Takehito Uruno, Motomu Kanai, Kounosuke Oisaki, Kuniko Saiki
"Agent for suppressing il-31 production and pharmaceutical composition containing the same"
Filed Patents: WO2022168961 (A1); US20240139214(A1); EP4289422(A4); CN117042759(A); JP2022579632(A)
出願者：国立大学法人九州大学・国立大学法人東京大学、公開日（WO）：2022/8/11 [Google Patent]
7) 金井求、生長幸之助、丸山勝矢、石山隆史、関陽平
「アミノ酸残基選択的な不可逆／可逆生体分子修飾法」
米国62/977730
出願者：国立大学法人東京大学、出願日：2020/2/18
6) 金井求、生長幸之助、笹本晃生、平野遼、松本拓也
「ペプチド合成法」
特許第7640994号 (JP2021130656A)
出願者：国立大学法人東京大学、登録日：2025/2/26 [J-PlatPat] [Google Patent]
5) Yoshinori Fukui, Takehito Uruno, Motomu Kanai, Kounosuke Oisaki, Ryosuke Tsutsumi
"Dock1-inhibiting compound and use thereof"
Filed patent: WO2020111252(A1); US20220017486(A1); CA3121445(A1); JP2020557868(A); BR112021010473(A2); CN113164444(A); AU2019390090(A1); EP3888651(A1); KR20210097735(A); IL283540(D0); MX2021006434(A)
出願者：国立大学法人九州大学、公開日（WO）：2020/6/4 [Google Patent]
4) Motomu Kanai, Kounosuke Oisaki, Takashi Ishiyama, Kuniko Saiki, Yohei Seki, Masaru Mitsuda, Keita Iguchi
"Antibody-drug complex and pharmaceutical composition containing same"
Filed Patents: WO2019150985 (A1)
出願者：国立大学法人東京大学・株式会社カネカ、公開日（WO）：2019/8/8[Google Patent]
3) Motomu Kanai, Kounosuke Oisaki, Yohei Seki, Daisuke Sasaki, Takashi Ishiyama
"Indole structure-selective crosslinking agent and composite in which same is used"
Filed Patents: WO2017154997 (A1); US20190100518(A1)
出願者：国立大学法人東京大学、公開日（WO）：2017/9/4 [Google Patent]
2) Motomu Kanai, Yohei Soma, Yusuke Shimizu, Atsuhiko Taniguchi, Kounosuke Oisaki, Yoichiro Kuninobu
"Boron-dipyrrin complex and medicament containing the same"
Filed Patents: WO2016143699(A1); US20180042948(A1); US10188671(B2); EP3266765(A1); EP3266765(A4); EP3266765(B1); JPWO2016143699(A1); JP6710435(B2)
出願者：科学技術振興機構（JST）、公開日（WO）：2016/9/15 [Google Patent]
1) Omar M. Yaghi, Alexander U. Czaja, Kounosuke Oisaki
"Organo-metallic frameworks derived from carbenophilic metals and methods of making same"
Filed Patents: WO2011146155 (A2); WO2011146155(A9); WO2011146155(A3); US2013131344 (A1); MX2012008941 (A1); KR20120129905 (A); BR112012019874(A2); JP2012553065(A); CA2788132 (A1); AU2011256793 (A1); CN102858455 (A); EP2533898 (A2); RU2012138958 (A); IN201206714 (P1)
出願者：BASF SE、公開日(WO)：2011/11/24 [Google Patent]