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Kounosuke OISAKI（生長 幸之助）, Ph.D.
Kounosuke OISAKI（生長 幸之助）, Ph.D.
Group Leader, Catalytic Chemistry Research Institute (CCRI)
National Institute of Advanced Industrial Science and Technology (AIST)
Group Leader, Catalytic Chemistry Research Institute (CCRI)
National Institute of Advanced Industrial Science and Technology (AIST)
Bridging the “In-Betweens” of Disciplines through Chemistry
Bridging the “In-Betweens” of Disciplines through Chemistry
We pursue catalytic reaction chemistry aimed at creating substances that lie “in-between” the natural and the artificial — above all, next-generation biocompatible materials known as proteomimetics. More recently, we have also been focusing on the development and societal implementation of inverse (N-to-C) peptide synthesis, which minimizes the use of protecting groups.
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Research Interests
Research Interests
Proteomimetics
Proteomimetics
Toward proteomimetics that lie “in-between” the natural and the artificial, we develop reaction chemistry that modifies biomolecules at the backbone level — including methods for peptide backbone modification and editing, and highly reliable ligation techniques.
Sustainable Peptide Synthesis
Sustainable Peptide Synthesis
Our inverse (N-to-C) peptide synthesis minimizes the use of protecting groups. We are advancing its societal implementation as a next-generation peptide manufacturing technology that combines low cost, low waste, and large-scale supply.
Novel Biofunctional Materials
Novel Biofunctional Materials
Building on tryptophan/tyrosine-selective protein modification and specialty peptide manufacturing, we develop biomaterials with new functions, including site-selective antibody–drug conjugates, selective labeling of exosome surfaces, gold-cluster-labeled antibodies, and functional peptides.
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